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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 382.8 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for cirsiliol usage levels up to: | | | not for fragrance use.
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| Recommendation for cirsiliol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 160237 |
| Pubchem (cas): | 34334-69-5 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5-hydroxy-6,7-dimethoxy- | | 2-(3,4- | dihydroxyphenyl)-5-hydroxy-6,7-dimethoxychromen-4-one | | 6,7- | dimethoxy-5,3',4'-trihydroxyflavone | | 3',4',5- | trihydroxy-6,7-dimethoxyflavone |
Articles:
| PubMed: | Bioactive flavones isolated from Tunisian Artemisia campestris L. Leaves. |
| PubMed: | Iridoid glycosides and polyphenolic compounds from Teucrium chamaedrys L. |
| PubMed: | [Studies on chemical constituents of Isodon excisoides]. |
| PubMed: | Phytochemical Analysis and Antioxidant Activity ofSalvia chloroleucaAerial Extracts. |
| PubMed: | [Chemical constituents from rhizomes of Iris germanica]. |
| PubMed: | HPLC-fingerprints and antioxidant constituents of Phyla nodiflora. |
| PubMed: | Further characterization of foliar flavonoids in Crossostephium chinense and their geographic variation. |
| PubMed: | Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells. |
| PubMed: | Antileishmanial Phenylpropanoids from the Leaves of Hyptis pectinata (L.) Poit. |
| PubMed: | Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines. |
| PubMed: | [Chemical constituents of Eupatorium lindleyanum]. |
| PubMed: | Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L. |
| PubMed: | Bis-spirolabdane diterpenoids from Leonotis nepetaefolia. |
| PubMed: | Effects of Teucrium polium spp. capitatum flavonoids on the lipid and carbohydrate metabolism in rats. |
| PubMed: | Flavones and rosmarinic acid from Salvia limbata. |
| PubMed: | Phytotoxic activity of Salvia x jamensis. |
| PubMed: | The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells. |
| PubMed: | Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. |
| PubMed: | [Determination of flavonoids in buds of Herba Artemisiae Scopariae by HPLC]. |
| PubMed: | Three new compounds from Isodon melissoides. |
| PubMed: | [Studies on chemical constituents in buds of Artemisia scoparia]. |
| PubMed: | GABA(A)-receptor ligands of flavonoid structure. |
| PubMed: | Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. |
| PubMed: | Sedative and hypnotic properties of Salvia guaranitica St. Hil. and of its active principle, Cirsiliol. |
| PubMed: | Cirsiliol and caffeic acid ethyl ester, isolated from Salvia guaranitica, are competitive ligands for the central benzodiazepine receptors. |
| PubMed: | [Resting tonus of isolated airway smooth muscles]. |
| PubMed: | Growth inhibition of human malignant glioma cells in vitro by agents which interfere with biosynthesis of eicosanoids. |
| PubMed: | Effects of cirsiliol, a flavone isolated from Achillea fragrantissima, on rat isolated ileum. |
| PubMed: | Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids. |
| PubMed: | Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs. |
| PubMed: | Mechanisms of action of lipoxygenase and cytochrome P-450-mono-oxygenase inhibitors in blocking endothelium-dependent vasodilatation. |
| PubMed: | Synergistic enhancement of mitogen responses of human lymphocytes by inhibitors of cyclo-oxygenase and lipoxygenase. |
| PubMed: | Arachidonate 5-lipoxygenase inhibitors show potent antiproliferative effects on human leukemia cell lines. |
| PubMed: | Syntheses of 5,6,7- and 5,7,8-trioxygenated 3',4'-dihydroxyflavones having alkoxy groups and their inhibitory activities against arachidonate 5-lipoxygenase. |
| PubMed: | Methylated Flavones from Teucrium polium. |
| PubMed: | Potent and selective 5-lipoxygenase inhibitors: cirsiliol and AA-861. |
| PubMed: | Studies on arachidonate 5-lipoxygenase of rat basophilic leukemia cells. |
| PubMed: | Arachidonate 5-lipoxygenase and its new inhibitors. |
| PubMed: | Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala. |
| PubMed: | Flavonoids: potent inhibitors of arachidonate 5-lipoxygenase. |
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