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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 1011 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Licochalcone B 98%
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| BOC Sciences |
| For experimental / research use only. |
| Licochalcone B >98%
Odor: characteristic Use: Licochalcone B is extracted from the roots of Glycyrrhiza glabra L. It inhibits the adhesion,invasion and metastasis of human malignant bladder cancer T24 cells. It could significantly reduce the LPS-induced production of NO, TNFalpha and MCP-1. |
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for licochalcone B usage levels up to: | | | not for fragrance use.
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| Recommendation for licochalcone B flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5318999 |
| Pubchem (cas): | 58749-23-8 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (E)-3-(3,4- | dihydroxy-2-methoxy-phenyl)-1-(4-hydroxy-phenyl)-propenone | | (E)-3-(3,4- | dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one |
Articles:
| PubMed: | Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells. |
| PubMed: | Intestinal Absorption of Triterpenoids and Flavonoids from Glycyrrhizae radix et rhizoma in the Human Caco-2 Monolayer Cell Model. |
| PubMed: | Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury. |
| PubMed: | Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice. |
| PubMed: | Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. |
| PubMed: | Protective role of licochalcone B against ethanol-induced hepatotoxicity through regulation of Erk signaling. |
| PubMed: | Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice. |
| PubMed: | Licochalcone B Arrests Cell Cycle Progression and Induces Apoptosis in Human Breast Cancer MCF-7 Cells. |
| PubMed: | Licochalcone B induces apoptosis of human oral squamous cell carcinoma through the extrinsic- and intrinsic-signaling pathways. |
| PubMed: | (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one, a novel licochalcone B derivative compound, suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice. |
| PubMed: | Cardioprotection against ischemia/reperfusion by licochalcone B in isolated rat hearts. |
| PubMed: | Antimetastatic effects of licochalcone B on human bladder carcinoma T24 by inhibition of matrix metalloproteinases-9 and NF-кB activity. |
| PubMed: | Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis. |
| PubMed: | Synthesis of licochalcone analogues with increased anti-inflammatory activity. |
| PubMed: | Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice. |
| PubMed: | [Phenolic constituents from Lysimachia patungensis]. |
| PubMed: | Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. |
| PubMed: | Activity of wen-pi-tang, and purified constituents of rhei rhizoma and glycyrrhizae radix against glucose-mediated protein damage. |
| PubMed: | Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase. |
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