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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 1292 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for isoliquiritin usage levels up to: | | | not for fragrance use.
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| Recommendation for isoliquiritin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5318591 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | (E)-1-(2,4-dihydroxyphenyl)-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-en-1-one |
| Chemidplus: | 0005041816 |
References:
| | (E)-1-(2,4-dihydroxyphenyl)-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-en-1-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5318591 |
| Pubchem (cas): | 5041-81-6 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (E)-1-(2,4- | dihydroxyphenyl)-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-en-1-one | | 2- | propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-(beta-D-glucopyranosyloxy)phenyl)-, (2E)- |
Articles:
| PubMed: | The effect of ethanol extract of Glycyrrhiza uralensis on the voltage-gated sodium channel subtype 1.4. |
| PubMed: | A Comparative Pharmacokinetic Study by UHPLC-MS/MS of Main Active Compounds after Oral Administration of Zushima-Gancao Extract in Normal and Adjuvant-Induced Arthritis Rats. |
| PubMed: | Simultaneous quantification of multiple components in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Huangqi decoction. |
| PubMed: | [Study on correlation between color and effective components contents of Glycyrrhiza uralensis]. |
| PubMed: | Neuroprotective effect of liquiritin as an antioxidant via an increase in glucose-6-phosphate dehydrogenase expression on B65 neuroblastoma cells. |
| PubMed: | Intestinal Absorption of Triterpenoids and Flavonoids from Glycyrrhizae radix et rhizoma in the Human Caco-2 Monolayer Cell Model. |
| PubMed: | Influence of Jiegeng on Pharmacokinetic Properties of Flavonoids and Saponins in Gancao. |
| PubMed: | Spasmolytic Mechanism of Aqueous Licorice Extract on Oxytocin-Induced Uterine Contraction through Inhibiting the Phosphorylation of Heat Shock Protein 27. |
| PubMed: | Simultaneous quantitation of six aconitum alkaloids and three flavonoids in the herb couple of radix aconiti lateralis-radix glycyrrhizae (Fuzi-Gancao) by UHPLC-ESI-MS/MS. |
| PubMed: | Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS. |
| PubMed: | Comparison of chemical constituents among licorice, roasted licorice, and roasted licorice with honey. |
| PubMed: | Simultaneous Determination of 8 Compounds in Gancao-Ganjiang-Tang by HPLC-DAD and Analysis of the Relations between Compatibility, Dosage, and Contents of Medicines. |
| PubMed: | Identification of NF-κB as Determinant of Posttraumatic Stress Disorder and Its Inhibition by the Chinese Herbal RemedyFree and Easy Wanderer. |
| PubMed: | Simultaneous determination of multiple active components in rat plasma using ultra-fast liquid chromatography with tandem mass spectrometry and application to a comparative pharmacokinetic study after oral administration of Suan-Zao-Ren decoction and Suan-Zao-Ren granule. |
| PubMed: | Protective effect of isoliquiritin against corticosterone-induced neurotoxicity in PC12 cells. |
| PubMed: | Development and validation of a sensitive and fast UPLC-MS/MS method for simultaneous determination of seven bioactive compounds in rat plasma after oral administration of Guizhi-gancao decoction. |
| PubMed: | Purification and characterization of a novel phloretin-2'-O-glycosyltransferase favoring phloridzin biosynthesis. |
| PubMed: | Identification and Chemical Standardization of Licorice Raw Materials and Dietary Supplements Using UHPLC-MS/MS. |
| PubMed: | Simultaneous Determinations of Eleven Bioactive Components in Suanzaoren Decoction Granules by High-Performance Liquid Chromatography and Its Application to the Quality Control in Productive Processes. |
| PubMed: | Simultaneous Determination of 18 Chemical Constituents in Traditional Chinese Medicine of Antitussive by UPLC-MS-MS. |
| PubMed: | Development and Validation of an UHPLC-QqQ-MS Technique for Simultaneous Determination of Ten Bioactive Components in Fangji Huangqi Tang. |
| PubMed: | Antifungal Activity of Isoliquiritin and Its Inhibitory Effect against Peronophythora litchi Chen through a Membrane Damage Mechanism. |
| PubMed: | [Effect of exogenous brassinolide on morphological characters and contents of seven chemical constituents of Glycyrrhiza uralensis]. |
| PubMed: | Online near-infrared analysis coupled with MWPLS and SiPLS models for the multi-ingredient and multi-phase extraction of licorice (Gancao). |
| PubMed: | Simultaneous quantification of catechin, epicatechin, liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, piperine and glycyrrhetinic acid in rat plasma by HPLC-MS/MS: application to a pharmacokinetic study of Longhu Rendan pills. |
| PubMed: | Comparison of the Spasmolytic Effects of Jakyak-Gamcho Decoctions Derived via Different Extractants. |
| PubMed: | Suppression of Propionibacterium acnes-Induced Dermatitis by a Traditional Japanese Medicine, Jumihaidokuto, Modifying Macrophage Functions. |
| PubMed: | Combination of the advantages of chromatographic methods based on active components for the quality evaluation of licorice. |
| PubMed: | The constituents of licorice (Glycyrrhiza uralensis) differentially suppress nitric oxide production in interleukin-1β-treated hepatocytes. |
| PubMed: | Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation. |
| PubMed: | Blood-brain barrier permeability of Gualou Guizhi granules and neuroprotective effects in ischemia/reperfusion injury. |
| PubMed: | Monitoring and evaluating the quality consistency of Compound Bismuth Aluminate tablets by a simple quantified ratio fingerprint method combined with simultaneous determination of five compounds and correlated with antioxidant activities. |
| PubMed: | Effect of genotype and environment on five bioactive components of cultivated licorice (Glycyrrhiza uralensis) populations in northern China. |
| PubMed: | Plant-derived natural medicines for the management of depression: an overview of mechanisms of action. |
| PubMed: | Studies on the identification of constituents in ethanol extract of Radix Glycyrrhizae and their anticancer activity. |
| PubMed: | Simultaneous Determination of Nine Active Compounds of the Traditional Chinese Medicinal Prescription Shaoyao-Gancao-Tang and Analysis of the Relationship between Therapeutical Effect and Compatibility of Medicines. |
| PubMed: | Effect of genotype and environment on five bioactive components of cultivated licorice (Glycyrrhiza uralensis FISCH.) populations in northern China. |
| PubMed: | Chemical interaction between Paeonia lactiflora and Glycyrrhiza uralensis, the components of Jakyakgamcho-tang, using a validated high-performance liquid chromatography method: herbal combination and chemical interaction in a decoction. |
| PubMed: | [Studies on effects of Achyranthes bidentata on tongsaimai pellets main active ingredients chlorogenic acid, isoliquiritin, harpagoside and glycyrrhizin in vivo pharmacokinetics]. |
| PubMed: | Distribution patterns of the contents of five active components in taproot and stolon of Glycyrrhiza uralensis. |
| PubMed: | Preparative isolation and analysis of alcohol dehydrogenase inhibitors from Glycyrrhiza uralensis root using ultrafiltration combined with high-performance liquid chromatography and high-speed countercurrent chromatography. |
| PubMed: | Simultaneous determination of 12 index components and compatibility changes in Longchai decoction by liquid chromatography-mass spectrometry. |
| PubMed: | [Multi-index determination and optimization of liquirtin separated from polyamide resin]. |
| PubMed: | Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress. |
| PubMed: | Correlation analysis between the rate of respiration in the root and the active components in licorice (Glycyrrhiza uralensis). |
| PubMed: | Combination of liquiritin, isoliquiritin and isoliquirigenin induce apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells. |
| PubMed: | Analysis of the traditional medicine YiGan San by the fragmentation patterns of cadambine indole alkaloids using HPLC coupled with high-resolution MS. |
| PubMed: | [Development of a rapid screening method for discovering neuroprotective components from traditional Chinese medicine]. |
| PubMed: | Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure. |
| PubMed: | Employing bifunctional enzymes for enhanced extraction of bioactives from plants: flavonoids as an example. |
| PubMed: | Pharmacokinetic comparisons of two different combinations of Shaoyao-Gancao Decoction in rats: competing mechanisms between paeoniflorin and glycyrrhetinic acid. |
| PubMed: | Pharmacokinetic comparisons of different combinations of Shaoyao-Gancao-Decoction in rats: simultaneous determination of ten active constituents by HPLC-MS/MS. |
| PubMed: | Pharmacokinetic study of four flavones of Glycyrrhiza in rat plasma using HPLC-MS. |
| PubMed: | HPLC method determination of isoliquiritin apioside and isoliquiritin in rat plasma for application in pharmacokinetic study after an oral administration of zhigancao extract. |
| PubMed: | Simultaneous quantitative determination of nine active chemical compositions in traditional Chinese medicine Glycyrrhiza by RP-HPLC with full-time five-wavelength fusion method. |
| PubMed: | Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses. |
| PubMed: | Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix. |
| PubMed: | Comparative analysis of the main bioactive components of San-ao decoction and its series of formulations. |
| PubMed: | Analytical strategy to reveal the in vivo process of multi-component herbal medicine: a pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry. |
| PubMed: | The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry. |
| PubMed: | Influence of honey-roasting on the main pharmacological activities and the water-soluble active glycosides of licorice. |
| PubMed: | Simultaneous determination of five flavonoids in licorice using pressurized liquid extraction and capillary electrochromatography coupled with peak suppression diode array detection. |
| PubMed: | Evaluation of antigenotoxic activity of isoliquiritin apioside from Glycyrrhiza glabra L. |
| PubMed: | Survey of Glycyrrhizae Radix resources in Mongolia: chemical assessment of the underground part of Glycyrrhiza uralensis and comparison with Chinese Glycyrrhizea Radix. |
| PubMed: | Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers. |
| PubMed: | [Selective adsorption of multi-walled carbon nanotubes with liquiritin and isoliquiritin]. |
| PubMed: | Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophages. |
| PubMed: | Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice. |
| PubMed: | Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information. |
| PubMed: | In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components. |
| PubMed: | Simultaneous quantification of multiple licorice flavonoids in rat plasma. |
| PubMed: | Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. |
| PubMed: | Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase. |
| PubMed: | Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang). |
| PubMed: | Relationship between the antidiarrhoeal effects of Hange-Shashin-To and its active components. |
| PubMed: | Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro. |
| PubMed: | [Chemical components of decoction of radix Paeoniae and radix Glycyrrhizae]. |
| PubMed: | Saponin and sapogenol. L. On the constituents of the roots of Glycyrrhiza uralensis Fischer from Xinjiang, China. Chemical structures of licorice-saponin L3 and isoliquiritin apioside. |
| PubMed: | [Quality evaluation of Chinese licorice]. |
| PubMed: | [HPLC analysis of flavonoids in the root of six Glycyrrhiza species]. |
| PubMed: | The existence of aldose reductase inhibitors in some kampo medicines (Oriental herb prescriptions). |
| PubMed: | [Studies on chemical constituents of Glycyrrhiza eurycarpa P. C. Li]. |
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