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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.01202 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for morusin usage levels up to: | | | not for fragrance use.
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| Recommendation for morusin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5281671 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one |
| Chemidplus: | 0062596296 |
References:
| | 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5281671 |
| Pubchem (cas): | 62596-29-6 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H,8H- | benzo(1,2-b:3,4-b')dipyran-4-one, 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methyl-2-butenyl)- | | 2-(2,4- | dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one | | | mulberrochromene |
Articles:
| PubMed: | UGT-mediated metabolism plays a dominant role in the pharmacokinetic behavior and the disposition of morusin in vivo and in vitro. |
| PubMed: | Synergism of prenylflavonoids from Morus alba root bark against clinical MRSA isolates. |
| PubMed: | Morusin induces paraptosis-like cell death through mitochondrial calcium overload and dysfunction in epithelial ovarian cancer. |
| PubMed: | Morusin inhibits cell proliferation and tumor growth by down-regulating c-Myc in human gastric cancer. |
| PubMed: | Prenylated flavonoid morusin protects against TNBS-induced colitis in rats. |
| PubMed: | Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition. |
| PubMed: | Two new prenylflavonoids from Morus alba. |
| PubMed: | Morusin induces apoptosis by regulating expression of Bax and Survivin in human breast cancer cells. |
| PubMed: | Quantification of morusin using LC-MS in rat plasma: Application to a pharmacokinetic study. |
| PubMed: | Two novel compounds from the root bark of Morus alba L. |
| PubMed: | Rapid, microwave-accelerated synthesis and anti-osteoporosis activities evaluation of Morusin scaffolds and Morusignin L scaffolds. |
| PubMed: | Autophagy inhibits cell death induced by the anti-cancer drug morusin. |
| PubMed: | Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood. |
| PubMed: | Involvement of the antioxidative property of morusin in blocking phorbol ester-induced malignant transformation of JB6 P+mouse epidermal cells. |
| PubMed: | Pharmacological Evaluation of the Recuperative Effect of Morusin Against Aluminium Trichloride (AlCl3)-Induced Memory Impairment in Rats. |
| PubMed: | Identification of the Metabolic Enzyme Involved Morusin Metabolism and Characterization of Its Metabolites by Ultraperformance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (UPLC/Q-TOF-MS/MS). |
| PubMed: | Morusin Induces TRAIL Sensitization by Regulating EGFR and DR5 in Human Glioblastoma Cells. |
| PubMed: | Blockage of STAT3 Signaling Pathway by Morusin Induces Apoptosis and Inhibits Invasion in Human Pancreatic Tumor Cells. |
| PubMed: | Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis. |
| PubMed: | The different metabolism of morusin in various species and its potent inhibition against UDP-glucuronosyltransferase (UGT) and cytochrome p450 (CYP450) enzymes. |
| PubMed: | [Chemical constituents from Morus notabilis and their cytotoxic effect]. |
| PubMed: | Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells. |
| PubMed: | Morusin inhibits glioblastoma stem cell growth in vitro and in vivo through stemness attenuation, adipocyte transdifferentiation, and apoptosis induction. |
| PubMed: | Antitumor progression potential of morusin suppressing STAT3 and NFκB in human hepatoma SK-Hep1 cells. |
| PubMed: | Preparation of morusin from Ramulus mori and its effects on mice with transplanted H22 hepatocarcinoma. |
| PubMed: | Effects of Morus alba L. and Natural Products Including Morusin on In Vivo Secretion and In Vitro Production of Airway MUC5AC Mucin. |
| PubMed: | A new antioxidant stilbene and other constituents from the stem bark of Morus nigra L. |
| PubMed: | [Study on the chemical constituents of mori cortex]. |
| PubMed: | Morusin inhibits human cervical cancer stem cell growth and migration through attenuation of NF-κB activity and apoptosis induction. |
| PubMed: | Virtual screening of Indonesian herbal database as HIV-1 reverse transcriptase inhibitor. |
| PubMed: | Protection of prenylated flavonoids from Mori Cortex Radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells. |
| PubMed: | Induction of Biologically Active Flavonoids in Cell Cultures of Morus nigra and Testing their Hypoglycemic Efficacy. |
| PubMed: | Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells. |
| PubMed: | Isolation of cholinesterase-inhibiting flavonoids from Morus lhou. |
| PubMed: | New isoprenylated flavonoid from Morus alba. |
| PubMed: | Cytotoxic prenylated flavonoids from Morus alba. |
| PubMed: | New isoprenylated flavonoids and cytotoxic constituents from Artocarpus tonkinensis. |
| PubMed: | Prenylated flavones from Artocarpus altilis. |
| PubMed: | [Studies on chemical constituents from twigs of Morus atropurpurea]. |
| PubMed: | Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz. |
| PubMed: | Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells. |
| PubMed: | Phenolic constituents from the wood of Morus australis with cytotoxic activity. |
| PubMed: | [Studies on chemical constituents from bark of Morus nigra]. |
| PubMed: | [Determination of morusin in cortex mori]. |
| PubMed: | Hypoglycemic effect of Egyptian Morus alba root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats. |
| PubMed: | Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai. |
| PubMed: | Antinephritis and radical scavenging activity of prenylflavonoids. |
| PubMed: | Root turnover: an important source of microbial substrates in rhizosphere remediation of recalcitrant contaminants. |
| PubMed: | Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases. |
| PubMed: | Effects of prenylated flavonoids and biflavonoids on lipopolysaccharide-induced nitric oxide production from the mouse macrophage cell line RAW 264.7. |
| PubMed: | Antinociceptive properties of morusin, a prenylflavonoid isolated from Morus nigra root bark. |
| PubMed: | Accurate mass measurement of low molecular weight compounds by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. |
| PubMed: | Chemistry and biological activities of constituents from Morus australis. |
| PubMed: | Bioactive constituents of Morus australis and Broussonetia papyrifera. |
| PubMed: | A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor. |
| PubMed: | Chemistry and anti-tumor promoting activity of Morus flavonoids. |
| PubMed: | Components of root bark of morus lhou1 1. Structures of two new natural diels-alder adducts, kuwanons N and o. |
| PubMed: | [Components of Root Bark of Morus australis.]. |
| PubMed: | Constituents of the Chinese crude drug "sāng-bái-pí" (Morus root bark). |
| PubMed: | Constituents of the cultivated mulberry tree. |
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