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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.9813 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for emodin anthrone usage levels up to: | | | not for fragrance use.
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| Recommendation for emodin anthrone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| European Food Safety Authority (EFSA) reference(s): |
Safety of hydroxyanthracene derivatives for use in food View page or View pdf |
| EPI System: | View |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 122635 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | 1,3,8-trihydroxy-6-methyl-10H-anthracen-9-one |
| Chemidplus: | 0000491601 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 9(10H)- | anthracenone, 1,3,8-trihydroxy-6-methyl- | | | emodinanthrone | | 1,3,8- | trihydroxy-6-methyl-10H-anthracen-9-one | | 1,3,8- | trihydroxy-6-methylanthrone |
Articles:
| PubMed: | Occurrence and Distribution of Phytochemicals in the Leaves of 17In vitroCulturedHypericumspp. Adapted to Outdoor Conditions. |
| PubMed: | Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones. |
| PubMed: | Barbaloin: a concise report of its pharmacological and analytical aspects. |
| PubMed: | In vitro formation of the anthranoid scaffold by cell-free extracts from yeast-extract-treated Cassia bicapsularis cell cultures. |
| PubMed: | Comparison of three different extraction methods and HPLC determination of the anthraquinones aloe-emodine, emodine, rheine, chrysophanol and physcione in the bark of Rhamnus alpinus L. (Rhamnaceae). |
| PubMed: | Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis. |
| PubMed: | Biosynthesis of actinorhodin and related antibiotics: discovery of alternative routes for quinone formation encoded in the act gene cluster. |
| PubMed: | [Studies on chemical constituents from rattan of Polygonum multiflorum]. |
| PubMed: | Octaketide-producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins. |
| PubMed: | Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells. |
| PubMed: | Rational elimination of Aspergillus terreus sulochrin production. |
| PubMed: | Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. |
| PubMed: | [Determination of six effective components in Rheum by cyclodextrin modified micellar electrokinetic chromatography]. |
| PubMed: | Permeation-enhancing effect of aloe-emodin anthrone on water-soluble and poorly permeable compounds in rat colonic mucosa. |
| PubMed: | Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus. |
| PubMed: | Simultaneous determination of Aloe-emodin and Rhein by synchronous fluorescence spectroscopy. |
| PubMed: | Hypotensive effect of chemical constituents from Aloe barbadensis. |
| PubMed: | Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma. |
| PubMed: | Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell. |
| PubMed: | Metabolism of 1,8-dihydroxy 3-hydroxy methyl anthraquinone (aloe-emodin) isolated from the leaves of Cassia tora in albino rats. |
| PubMed: | [Biologically active substances isolated from Hypericum attenuatum Choisy]. |
| PubMed: | Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride. |
| PubMed: | Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. |
| PubMed: | Synergistic effects of anthraquinones on the purgative activity of rhein anthrone in mice. |
| PubMed: | The synergistic purgative action of aloe-emodin anthrone and rhein anthrone in mice: synergism in large intestinal propulsion and water secretion. |
| PubMed: | A purgative action of barbaloin is induced by Eubacterium sp. strain BAR, a human intestinal anaerobe, capable of transforming barbaloin to aloe-emodin anthrone. |
| PubMed: | Bioactive anthraquinone glycosides from Picramnia antidesma spp. fessonia. |
| PubMed: | Studies of aloe. V. Mechanism of cathartic effect. (4). |
| PubMed: | Metabolic activation of sennoside C in mice: synergistic action of anthrones. |
| PubMed: | Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus. |
| PubMed: | Identification of emodinanthrone oxygenase in fungus Aspergillus terreus. |
| PubMed: | In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives. |
| PubMed: | Barbaloin stimulates growth of Eubacterium sp. strain BAR, a barbaloin-metabolizing bacterium from human feces. |
| PubMed: | Isolation of a human intestinal bacterium capable of transforming barbaloin to aloe-emodin anthrone. |
| PubMed: | Studies of aloe. III. Mechanism of cathartic effect. (2). |
| PubMed: | [Purification, glucose-6-phosphate dehydrogenase inhibition, and HPLC analysis of four 1,8-dihydroxyanthrones]. |
| PubMed: | Structure-activity relationships for epidermal ornithine decarboxylase induction and skin tumor promotion by anthrones. |
| PubMed: | Inhibition of electron transfer and uncoupling effects by emodin and emodinanthrone in Escherichia coli. |
| PubMed: | Anthraquinones, Anthrones and Dianthrones in Callus Cultures of Rhamnus frangula and Rhamnus purshiana. |
| PubMed: | In vitro biosynthesis of the C-glycosidic bond in aloin. |
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