|
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 1e+006 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for Geniposidic acid usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for Geniposidic acid flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 443354 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid |
| Chemidplus: | 0027741011 |
References:
| | (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 443354 |
| Pubchem (cas): | 27741-01-1 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cyclopenta(c)pyran-4-carboxylic acid, 1-(beta-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, (1S,4aS,7aS)- | | (1S,4aS,7aS)-7-( | hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid |
Articles:
| PubMed: | Comparison of Multiple Bioactive Constituents in Different Parts of Eucommia ulmoides Based on UFLC-QTRAP-MS/MS Combined with PCA. |
| PubMed: | [Chemical constituents from hypoglycemic active part of Plantaginis Semen]. |
| PubMed: | Iridoids and sfingolipids from Hedyotis diffusa. |
| PubMed: | [Difference of chemical constituents in Eucommiae Cortex from different habitats by LC-QTOF MS/MS]. |
| PubMed: | [Analysis on pharmacokinetics-pharmacodynamics correlation of effective ingredients of Qing'e wan]. |
| PubMed: | Mid-infrared and near-infrared spectroscopy for rapid detection of Gardeniae Fructus by a liquid-liquid extraction process. |
| PubMed: | Online microdialysis-ultra performance liquid chromatography-mass spectrometry method for comparative pharmacokinetic investigation on iridoids from Gardenia jasminoides Ellis in rats with different progressions of type 2 diabetic complications. |
| PubMed: | Research survey on iridoid and phenylethanoid glycosides among seven populations of Euphrasia rostkoviana Hayne from the Alps. |
| PubMed: | Preventive effect of Eucommia leaf extract on aortic media hypertrophy in Wistar-Kyoto rats fed a high-fat diet. |
| PubMed: | A novel UPLC-MS/MS method for simultaneous determination of 10 effective constituents in the Jixingshizhen preparation. |
| PubMed: | Application of a quantitative1H-NMR (1H-qNMR) method for the determination of geniposidic acid and acteoside in Plantaginis semen. |
| PubMed: | Pharmacokinetics and Disposition of Circulating Iridoids and Organic Acids in Rats Intravenously Receiving ReDuNing Injection. |
| PubMed: | Morinlongosides A-C, Two New Naphthalene Glycoside and a New Iridoid Glycoside from the Roots of Morinda longissima. |
| PubMed: | Simultaneous Determination of Catalpol, Aucubin, and Geniposidic Acid in Different Developmental Stages of Rehmannia glutinosa Leaves by High Performance Liquid Chromatography. |
| PubMed: | Comprehensive Evaluation of the Metabolism of Genipin-1-β-d-gentiobioside in Vitro and in Vivo by Using HPLC-Q-TOF. |
| PubMed: | Pharmacokinetics and tissue distribution of five active ingredients of Eucommiae cortex in normal and ovariectomized mice by UHPLC-MS/MS. |
| PubMed: | Two standardized fractions of Gardenia jasminoides Ellis with rapid antidepressant effects are differentially associated with BDNF up-regulation in the hippocampus. |
| PubMed: | Simultaneous Determination of 11 Components in Yinzhihuang Preparations and Their Constituent Herbs by High-Performance Liquid Chromatography with Diode Array Detector. |
| PubMed: | Metabolic profile of Fructus Gardeniae in human plasma and urine using ultra high-performance liquid chromatography coupled with high-resolution LTQ-orbitrap mass spectrometry. |
| PubMed: | Geniposidic acid protected against ANIT-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2. |
| PubMed: | [Study on quality standard of Eucommia ulmoides based on absorbed active components in rat plasma]. |
| PubMed: | Simultaneous quantitation and validation of method for the quality evaluation of Eucommiae cortex by HPLC/UV. |
| PubMed: | Quality control of Gardeniae Fructus by HPLC-PDA fingerprint coupled with chemometric methods. |
| PubMed: | Herb extracts and collagen hydrolysate improve skin damage resulting from ultraviolet-induced aging in hairless mice. |
| PubMed: | A UPLC-MS Method for Simultaneous Determination of Geniposidic Acid, Two Lignans and Phenolics in Rat Plasma and its Application to Pharmacokinetic Studies of Eucommia ulmoides Extract in Rats. |
| PubMed: | UPLC-MS/MS determination and gender-related pharmacokinetic study of five active ingredients in rat plasma after oral administration of Eucommia cortex extract. |
| PubMed: | [Determination of eleven major components and fingerprint chromatography for Reduning injection by UPLC]. |
| PubMed: | [Investigation on chemical constituents of processed products of Eucommiae Cortex]. |
| PubMed: | Systematic separation and purification of iridoid glycosides and crocetin derivatives from Gardenia jasminoides Ellis by high-speed counter-current chromatography. |
| PubMed: | [UPLC-MS/MS determination of content of three iridoids of xingnaojing oral preparation in rat brains and study on their brain pharmacokinetics]. |
| PubMed: | Simultaneous multi-component quantitation of Chinese herbal injection Yin-zhi-huang in rat plasma by using a single-tube extraction procedure for mass spectrometry-based pharmacokinetic measurement. |
| PubMed: | [Study on chemical constituents of iridoids from eucommiae folium]. |
| PubMed: | Iridoid glycosides isolated from Scrophularia dentata Royle ex Benth. and their anti-inflammatory activity. |
| PubMed: | LC/MS/MS determination and pharmacokinetic studies of six compounds in rat plasma following oral administration of the single and combined extracts of Eucommia ulmoides and Dipsacus asperoides. |
| PubMed: | Anti-atherosclerotic effect of geniposidic acid in a rabbit model and related cellular mechanisms. |
| PubMed: | Development and validation of high liquid performance chromatography-tandem mass spectrometry method for simultaneous determination of geniposidic acid and aucubin in rat plasma for pharmacokinetic study after oral administration of Du-zhong tea extract. |
| PubMed: | Effects of fructus psoraleae extract on the intestinal absorption kinetics of geniposide and geniposidic acid in rat. |
| PubMed: | Isolation and characterisation of (-)-genifuranal: the principal antimicrobial component in traditional smoking applications of Eremophila longifolia (Scrophulariaceae) by Australian aboriginal peoples. |
| PubMed: | Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors. |
| PubMed: | Simultaneous determination of bioactive marker compounds from Gardeniae fructus by high performance liquid chromatography. |
| PubMed: | Quality control and producing areas differentiation of Gardeniae Fructus for eight bioactive constituents by HPLC-DAD-ESI/MS. |
| PubMed: | Simultaneous ligand fishing and identification of human serum albumin binders from Eucommia ulmoides bark using surface plasmon resonance-high performance liquid chromatography-tandem mass spectrometry. |
| PubMed: | Anti-inflammatory activity of iridoids and verbascoside isolated from Castilleja tenuiflora. |
| PubMed: | Heat shock factor 1 inducers from the bark of Eucommia ulmoides as cytoprotective agents. |
| PubMed: | Identification and quantification of phytochemical composition and anti-inflammatory, cellular antioxidant, and radical scavenging activities of 12 Plantago species. |
| PubMed: | Preparative isolation and purification of seven main antioxidants from Eucommia ulmoides Oliv. (Du-zhong) leaves using HSCCC guided by DPPH-HPLC experiment. |
| PubMed: | A sensitive liquid chromatographic-mass spectrometric method for simultaneous quantification of six iridoid glycosides from Zhi-zi-chi Decoction in rat plasma and its application to a pharmacokinetic study. |
| PubMed: | Determination and pharmacokinetics of geniposidic acid in rat plasma after oral administration of Gardenia jasminoides fruit crude extract and Zhi-zi-chi decoction. |
| PubMed: | Seasonal difference in antioxidant capacity and active compounds contents of Eucommia ulmoides oliver leaf. |
| PubMed: | Geniposidic acid protects against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice. |
| PubMed: | Iridoids from Bellardia trixago (L.) All. |
| PubMed: | [Simultaneous determination of eight iridoid glycosides in Gardeniae fructus by HPLC]. |
| PubMed: | Screening, identification, and potential interaction of active compounds from Eucommia ulmodies leaves binding with bovine serum albumin. |
| PubMed: | Determination of geniposidic acid in rat plasma by LC-MS/MS and its application to in vivo pharmacokinetic studies. |
| PubMed: | Asperuloside stimulates metabolic function in rats across several organs under high-fat diet conditions, acting like the major ingredient of Eucommia leaves with anti-obesity activity. |
| PubMed: | A new carotenoid glycoside from Rehmannia glutinosa. |
| PubMed: | [Study on absorption ingredients of Plantaginis semen by in vitro everted intestinal sac method]. |
| PubMed: | Secondary metabolites from Asperula lutea subsp. rigidula. |
| PubMed: | Anti-obesity compounds in green leaves of Eucommia ulmoides. |
| PubMed: | Quality control of a herbal medicinal preparation using high-performance liquid chromatographic and capillary electrophoretic methods. |
| PubMed: | Identification and determination of the major constituents in traditional Chinese medicine Longdan Xiegan Pill by HPLC-DAD-ESI-MS. |
| PubMed: | Scyphiphin D, a new iridoid glucoside dimer from Scyphiphora hydrophyllacea. |
| PubMed: | [Chemical constituents of stems and branches of Adina polycephala]. |
| PubMed: | [Study of geniposide-acid on anti-inflammatory action for adjuvant-induced arthritis rats and mechanism of synoviocyte apoptosis in vitro]. |
| PubMed: | Melanogenesis inhibitory activities of iridoid-, hemiterpene-, and fatty acid-glycosides from the fruits of Morinda citrifolia (Noni). |
| PubMed: | Studies on the antioxidant activity and phenolic compounds of enzyme-assisted water extracts from Du-zhong (Eucommia ulmoides Oliv.) leaves. |
| PubMed: | Protective effects of Eucommia ulmoides Oliv. bark and leaf on amyloid β-induced cytotoxicity. |
| PubMed: | Focused microwave-assisted solvent extraction and HPLC determination of effective constituents in Eucommia ulmodies Oliv. (E. ulmodies). |
| PubMed: | Inhibitory Potencies of Several Iridoids on Cyclooxygenase-1, Cyclooxygnase-2 Enzymes Activities, Tumor Necrosis factor-α and Nitric Oxide Production In Vitro. |
| PubMed: | Iridoid glucosides with insecticidal activity from Galium melanantherum. |
| PubMed: | [Determination of geniposidic acid and chlorogenic acid in male flowers and related products of Eucommia ulmoides by reversed-phase high performance liquid chromatography]. |
| PubMed: | Aglycone geniposidic acid, a naturally occurring crosslinking agent, and its application for the fixation of collagenous tissues. |
| PubMed: | Bioassay-guided isolation of anti-inflammatory and antinociceptive glycoterpenoids from the flowers of Verbascum lasianthum Boiss. ex Bentham. |
| PubMed: | Physicochemical, antimicrobial, and cytotoxic characteristics of a chitosan film cross-linked by a naturally occurring cross-linking agent, aglycone geniposidic acid. |
| PubMed: | Simultaneous determination of key bioactive components in Hedyotis diffusa by capillary electrophoresis. |
| PubMed: | [Isolation, purification and identification of geniposidic acid in Eucommia ulmoides oliv. by silica column chromatography, reversed-phase high performance liquid chromatography, liquid chromatography-electrospray ionization mass spectrometry and nuclear magnetic resonance]. |
| PubMed: | Iridoid glycosides isolated from Oldenlandia diffusa inhibit LDL-oxidation. |
| PubMed: | Iridoid glucosides from the fruit of Genipa americana. |
| PubMed: | [Study on technology of extracting geniposidic acid from Eucommia ulmiodes and its application]. |
| PubMed: | Phytochemical constituents from Diodia teres. |
| PubMed: | Effects of Eucommiae Cortex on osteoblast-like cell proliferation and osteoclast inhibition. |
| PubMed: | [Simultaneous determination of 3 kinds of components in Gardenia by high-performance liquid chromatography under different UV-vis wave length]. |
| PubMed: | [Studies on chemical constituents of Cistanche tubulosa (Schenk) R. Wight]. |
| PubMed: | [A study on chemical composition of Gardenia sootepensis Hutch--quantitative determination of iridoid compounds by RP-HPLC]. |
| PubMed: | [Chemical constituents of fruits of Gardenia sootepensis Hutch]. |
| PubMed: | Iridoids from Avicennia marina. |
| PubMed: | Constituents and pharmacological effects of Eucommia and Siberian ginseng. |
| PubMed: | Determination of iridoid glycosides by micellar electrokinetic capillary chromatography-mass spectrometry with use of the partial filling technique. |
| PubMed: | Selective sequestration of iridoid glycosides from their host plants in Longitarsus flea beetles. |
| PubMed: | Iridoid glycosides from Globularia trichosantha. |
| PubMed: | An iridoid glucoside from Euphrasia pectinata. |
| PubMed: | Triterpene saponins and iridoid glucosides from galium rivale. |
| PubMed: | Iridoid glycosides from Gmelina philippensis. |
| PubMed: | Aquaticol, a bis-sesquiterpene and iridoid glucosides from Veronica anagallis-aquatica. |
| PubMed: | The promoting effect of eucommiol from Eucommiae cortex on collagen synthesis. |
| PubMed: | Improvement in the turnover rate of the stratum corneum in false aged model rats by the administration of geniposidic acid in Eucommia ulmoides Oliver Leaf. |
| PubMed: | The promoting effects of geniposidic acid and aucubin in Eucommia ulmoides Oliver leaves on collagen synthesis. |
| PubMed: | Comparisons of geniposidic acid and geniposide on antitumor and radioprotection after sublethal irradiation. |
| PubMed: | Antimutagenicity of Tochu tea (an aqueous extract of Eucommia ulmoides leaves): 1. The clastogen-suppressing effects of Tochu tea in CHO cells and mice. |
| PubMed: | Cardioactive compounds from Eremophila species. |
| PubMed: | Enzymic studies on the animal and intestinal bacterial metabolism of geniposide. |
| PubMed: | [HPLC determination of iridoids in Cape jasmine Frvit (Zhizi)]. |
| PubMed: | Production of anti-tumor-promoting iridoid glucosides in Genipa americana and its cell cultures. |
| PubMed: | Determination of geniposide, gardenoside, geniposidic acid and genipin-1-beta-gentiobioside in Gardenia jasminoides by high-performance liquid chromatography. |
| PubMed: | Radiatoside B and C, Two New Bisiridoid Glucosides from Argylia radiata1. |
| PubMed: | Studies on monoterpene glucosides and related natural products. |
| PubMed: | Iridoids from Premna latifolia. |
|