cucurbitacin B, 6199-67-3

Articles:

PubMed:	Association of textile industry effluent with mutagenicity and its toxic health implications upon acute and sub-chronic exposure.
PubMed:	Natural Terpenoids Against Female Breast Cancer: a 5-year Recent Research.
PubMed:	Cucurbitacin B suppresses metastasis mediated by reactive oxygen species (ROS) via focal adhesion kinase (FAK) in breast cancer MDA-MB-231 cells.
PubMed:	Cucurbitacin B induces inhibitory effects via CIP2A/PP2A/Akt pathway in glioblastoma multiforme.
PubMed:	Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling.
PubMed:	Cucurbitacin-B attenuates CCl₄-induced hepatic fibrosis in mice through inhibition of STAT-3.
PubMed:	Cucurbitacin B acts a potential insect growth regulator by antagonizing 20-hydroxyecdysone activity.
PubMed:	Exploring the Cytotoxic Potential of Triterpenoids-enriched Fraction ofBacopa monnieriby ImplementingIn vitro,In vivo, andIn silicoApproaches.
PubMed:	Cucurbitacin B and cancer intervention: Chemistry, biology and mechanisms (Review).
PubMed:	Simultaneous determination of cucurbitacin B and cucurbitacin E in rat plasma by UHPLC-MS/MS: A pharmacokinetics study after oral administration of cucurbitacin tablets.
PubMed:	Inhibition of paclitaxel resistance and apoptosis induction by cucurbitacin B in ovarian carcinoma cells.
PubMed:	Cucurbitacin B inhibits cell proliferation and induces apoptosis in human osteosarcoma cells via modulation of the JAK2/STAT3 and MAPK pathways.
PubMed:	Antitumor effectiveness of a combined therapy with a new cucurbitacin B derivative and paclitaxel on a human lung cancer xenograft model.
PubMed:	Cucurbitacins: elucidation of their interactions with the cytoskeleton.
PubMed:	Cucurbitacin B induces autophagy and apoptosis by suppressing CIP2A/PP2A/mTORC1 signaling axis in human cisplatin resistant gastric cancer cells.
PubMed:	Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy.
PubMed:	Simultaneous determination of cucurbitacin B, E, I and E-glucoside in plant material and body fluids by HPLC-MS.
PubMed:	Protective Effects of Cucurbitacin B on Acute Lung Injury Induced by Sepsis in Rats.
PubMed:	Cucurbitacin B synergistically enhances the apoptosis-inducing effect of arsenic trioxide by inhibiting STAT3 phosphorylation in lymphoma Ramos cells.
PubMed:	Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells.
PubMed:	Cucurbitacin B purified from Ecballium elaterium (L.) A. Rich from Tunisia inhibits α5β1 integrin-mediated adhesion, migration, proliferation of human glioblastoma cell line and angiogenesis.
PubMed:	PTEN Activation by DNA Damage Induces Protective Autophagy in Response to Cucurbitacin B in Hepatocellular Carcinoma Cells.
PubMed:	Sestrin-3 modulation is essential for therapeutic efficacy of cucurbitacin B in lung cancer cells.
PubMed:	Anticancer effect of cucurbitacin B on MKN-45 cells via inhibition of the JAK2/STAT3 signaling pathway.
PubMed:	Therapeutic potential of Benincasa cerifera: A review.
PubMed:	Cucurbitacin B exerts anti-cancer activities in human multiple myeloma cells in vitro and in vivo by modulating multiple cellular pathways.
PubMed:	Cucurbitacin B reverses multidrug resistance by targeting CIP2A to reactivate protein phosphatase 2A in MCF-7/adriamycin cells.
PubMed:	Cucurbitacin B inhibits breast cancer metastasis and angiogenesis through VEGF-mediated suppression of FAK/MMP-9 signaling axis.
PubMed:	A biotransformation process for the production of cucurbitacin B from its glycoside using a selected Streptomyces sp.
PubMed:	Cucurbitacin B inhibits the stemness and metastatic abilities of NSCLC via downregulation of canonical Wnt/β-catenin signaling axis.
PubMed:	Cucurbitacin B Enhances the Anticancer Effect of Imatinib Mesylate Through Inhibition of MMP-2 Expression in MCF-7 and SW480 Tumor Cell Lines.
PubMed:	Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549.
PubMed:	[Rat intestine absorption kinetics study on cucurbitacin B-sodium deoxycholate/phospholipid mixed nanomicelles with in vitro everted gut sacs model].
PubMed:	Cucurbitacins: A Systematic Review of the Phytochemistry and Anticancer Activity.
PubMed:	Modulation of signal transduction pathways by natural compounds in cancer.
PubMed:	Cucurbitacins attenuate microglial activation and protect from neuroinflammatory injury through Nrf2/ARE activation and STAT/NF-κB inhibition.
PubMed:	Cucurbitacin B inhibits immunomodulatory function and the inflammatory response in macrophages.
PubMed:	Synergistic effect of cucurbitacin B in combination with curcumin via enhancing apoptosis induction and reversing multidrug resistance in human hepatoma cells.
PubMed:	A simple LC-MS method for determination of cyasterone in rat plasma: application to a pilot pharmacokinetic study.
PubMed:	Synergistic Antiproliferative Effects of a New Cucurbitacin B Derivative and Chemotherapy Drugs on Lung Cancer Cell Line A549.
PubMed:	Hepatoprotective and proapoptotic effect of Ecballium elaterium on CCl4-induced hepatotoxicity in rats.
PubMed:	Approach for chemosensitization of cisplatin-resistant ovarian cancer by cucurbitacin B.
PubMed:	Development and validation of a UPLC-MS/MS method for the determination of cucurbitacin B in rat plasma and application to a pharmacokinetic study.
PubMed:	Treatment with cucurbitacin B alone and in combination with gefitinib induces cell cycle inhibition and apoptosis via EGFR and JAK/STAT pathway in human colorectal cancer cell lines.
PubMed:	Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells.
PubMed:	Anticancer and anti-inflammatory activities of some dietary cucurbits.
PubMed:	Effective mucoadhesive water-soluble polymers for the solidification transformation of phospholipid-bile salts-mixed micelles.
PubMed:	The role of STAT3 in autophagy.
PubMed:	Improve bile duct-targeted drug delivery and therapeutic efficacy for cholangiocarcinoma by cucurbitacin B loaded phospholipid complex modified with berberine hydrochloride.
PubMed:	Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis.
PubMed:	Inhibitory effect of cucurbitacin B on imiquimod-induced skin inflammation.
PubMed:	Corrigendum to "Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest".
PubMed:	In vitro and in vivo antitumor activity of a novel semisynthetic derivative of cucurbitacin B.
PubMed:	Potential New Pharmacological Agents Derived From Medicinal Plants for the Treatment of Pancreatic Cancer.
PubMed:	Cucurbitacin-B inhibits neuroblastoma cell proliferation through up-regulation of PTEN.
PubMed:	[Preparation and characterization of cucurbitacin B sodium deoxycholate/phospholipid-mixed oral fast dissolving film and antitumor activity study].
PubMed:	Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung cancer cells.
PubMed:	HER2 mediated de novo production of TGFβ leads to SNAIL driven epithelial-to-mesenchymal transition and metastasis of breast cancer.
PubMed:	Molecular dynamics study of the diffusivity of a hydrophobic drug Cucurbitacin B in pseudo-poly(ethylene oxide-b-caprolactone) micelle environments.
PubMed:	Cucurbitacin B induces DNA damage, G2/M phase arrest, and apoptosis mediated by reactive oxygen species (ROS) in leukemia K562 cells.
PubMed:	Cucurbitacin B inhibits growth and induces apoptosis through the JAK2/STAT3 and MAPK pathways in SH‑SY5Y human neuroblastoma cells.
PubMed:	Carbon and fullerene nanomaterials in plant system.
PubMed:	Inhibition of Integrin-HER2 signaling by Cucurbitacin B leads to in vitro and in vivo breast tumor growth suppression.
PubMed:	VASP activation via the Gα13/RhoA/PKA pathway mediates cucurbitacin-B-induced actin aggregation and cofilin-actin rod formation.
PubMed:	Inactivation of ATP citrate lyase by Cucurbitacin B: A bioactive compound from cucumber, inhibits prostate cancer growth.
PubMed:	Application of spray granulation for conversion of mixed phospholipid-bile salt micelles to dry powder form: influence of drug hydrophobicity on nanoparticle reagglomeration.
PubMed:	Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner.
PubMed:	Mucoadhesive buccal films containing phospholipid-bile salts-mixed micelles as an effective carrier for Cucurbitacin B delivery.
PubMed:	Cucurbitacin B inhibits the translational expression of hypoxia-inducible factor-1α.
PubMed:	Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling.
PubMed:	The anti-melanoma efficiency of the intratumoral injection of cucurbitacin-loaded sustained-release carriers: a PLGA particle system.
PubMed:	Formation of cofilin-actin rods following cucurbitacin-B-induced actin aggregation depends on Slingshot homolog 1-mediated cofilin hyperactivation.
PubMed:	Nanobiotechnology can boost crop production and quality: first evidence from increased plant biomass, fruit yield and phytomedicine content in bitter melon (Momordica charantia).
PubMed:	Steroid hormone signaling is involved in the age-dependent behavioral response to sex pheromone in the adult male moth Agrotis ipsilon.
PubMed:	The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells.
PubMed:	Cucurbitacin B and its rapidly emerging role in the management of systemic malignancies besides lung carcinomas.
PubMed:	Cucurbitacin B potently suppresses non-small-cell lung cancer growth: identification of intracellular thiols as critical targets.
PubMed:	The triterpenoid cucurbitacin B augments the antiproliferative activity of chemotherapy in human breast cancer.
PubMed:	Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation.
PubMed:	Preparation, characterization, cellular uptake and evaluation in vivo of solid lipid nanoparticles loaded with cucurbitacin B.
PubMed:	Cucurbitacin B regulates immature myeloid cell differentiation and enhances antitumor immunity in patients with lung cancer.
PubMed:	Cucurbitacin B induces cell cycle arrest, apoptosis and autophagy associated with G actin reduction and persistent activation of cofilin in Jurkat cells.
PubMed:	Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest.
PubMed:	Synthesis and cytotoxic activity evaluation of dihydrocucurbitacin B and cucurbitacin B derivatives.
PubMed:	Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis.
PubMed:	The definition and significance of Cucurbitacin B a STAT3 inhibitors.
PubMed:	Cucurbitacin B inhibits 12-O-tetradecanoylphorbol 13-acetate-induced invasion and migration of human hepatoma cells through inactivating mitogen-activated protein kinase and PI3K/Akt signal transduction pathways.
PubMed:	Cucurbitacins-type triterpene with potent activity on mouse embryonic fibroblast from Cucumis prophetarum, cucurbitaceae.
PubMed:	Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus.
PubMed:	[Studies on chemical constituents in roots of Helicteres angustifolia].
PubMed:	Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells.
PubMed:	Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment.
PubMed:	Synergistic effect of low-dose cucurbitacin B and low-dose methotrexate for treatment of human osteosarcoma.
PubMed:	Cucurbitacin B suppresses the transactivation activity of RelA/p65.
PubMed:	Studies toward the total syntheses of cucurbitacins B and D.
PubMed:	Cucurbitacin B inhibits growth, arrests the cell cycle, and potentiates antiproliferative efficacy of cisplatin in cutaneous squamous cell carcinoma cell lines.
PubMed:	Cucurbitacin B, a novel in vivo potentiator of gemcitabine with low toxicity in the treatment of pancreatic cancer.
PubMed:	Cucurbitacin B, a small molecule inhibitor of the Stat3 signaling pathway, enhances the chemosensitivity of laryngeal squamous cell carcinoma cells to cisplatin.
PubMed:	An isoaurone and other constituents from Trichosanthes kirilowii seeds inhibit hypoxia-inducible factor-1 and nuclear factor-kappaB.
PubMed:	Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells.
PubMed:	Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling.
PubMed:	Cucurbitacin B induces apoptosis and S phase cell cycle arrest in BEL-7402 human hepatocellular carcinoma cells and is effective via oral administration.
PubMed:	Galactosylated solid lipid nanoparticles with cucurbitacin B improves the liver targetability.
PubMed:	Antiproliferative effects of cucurbitacin B in breast cancer cells: down-regulation of the c-Myc/hTERT/telomerase pathway and obstruction of the cell cycle.
PubMed:	Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells.
PubMed:	Prediction of the solubility of cucurbitacin drugs in self-associating poly(ethylene oxide)-b-poly(alpha-benzyl carboxylate epsilon-caprolactone) block copolymer with different tacticities using molecular dynamics simulation.
PubMed:	Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562.
PubMed:	Roles of nonpolar and polar intermolecular interactions in the improvement of the drug loading capacity of PEO-b-PCL with increasing PCL content for two hydrophobic Cucurbitacin drugs.
PubMed:	Cucurbitacin B induces apoptosis by inhibition of the JAK/STAT pathway and potentiates antiproliferative effects of gemcitabine on pancreatic cancer cells.
PubMed:	Interaction of cucurbitacins with human serum albumin: Thermodynamic characteristics and influence on the binding of site specific ligands.
PubMed:	Cucurbitane-type triterpenoids from the stems of Cucumis melo.
PubMed:	Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina.
PubMed:	Cogniauxia podolaena: bioassay-guided fractionation of defoliated stems, isolation of active compounds, antiplasmodial activity and cytotoxicity.
PubMed:	[Effects of cucurbitacin B on cell proliferation and apoptosis in Hep-2 cells].
PubMed:	Cucurbitacin B has a potent antiproliferative effect on breast cancer cells in vitro and in vivo.
PubMed:	Cucurbitacin B markedly inhibits growth and rapidly affects the cytoskeleton in glioblastoma multiforme.
PubMed:	Targeted constitutive activation of signal transducer and activator of transcription 3 in human hepatocellular carcinoma cells by cucurbitacin B.
PubMed:	Combined antitumor activity of cucurbitacin B and docetaxel in laryngeal cancer.
PubMed:	Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells.
PubMed:	Inhibitory effects of cucurbitacin B on laryngeal squamous cell carcinoma.
PubMed:	Octanorcucurbitane and cucurbitane triterpenoids from the tubers of Hemsleya endecaphylla with HIV-1 inhibitory activity.
PubMed:	Cucurbitacin glucosides: antioxidant and free-radical scavenging activities.
PubMed:	Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors.
PubMed:	[Determination of the cucurbitacins from Cucubita pepo cv dayangua by HPLC].
PubMed:	Small molecule inhibitors of Stat3 signaling pathway.
PubMed:	Phytochemical and biological investigation of Begonia heracleifolia.
PubMed:	Cucurbitane triterpenes from the fruiting bodies and cultivated mycelia of Leucopaxillus gentianeus.
PubMed:	Studies on the cytotoxicity of cucurbitacins isolated from Cayaponia racemosa (Cucurbitaceae).
PubMed:	Cucurbitacin B 2-sulfate and cucurbitacin glucosides from the root bark of Helicteres angustifolia.
PubMed:	Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells.
PubMed:	Cucurbitacin glucosides from Citrullus colocynthis.
PubMed:	[Relationships of Aulacophora beetles feeding behavior with cucurbitacin types in host crops].
PubMed:	Cucurbitacins and cucurbitane glycosides: structures and biological activities.
PubMed:	[Studies on chemical constituents in bulbs of Bolbostemma paniculatum].
PubMed:	Isolation of ani-hepatotoxic principle form the juice of Ecballium elaterium.
PubMed:	Cucurbitane triterpenoids from Leucopaxillus gentianeus.
PubMed:	Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis.
PubMed:	Callus formation and cucurbitacin B accumulation in Ecballium elaterium callus cultures.
PubMed:	The effect of manipulating ecdysteroid signaling on embryonic eye development in the locust Schistocerca americana.
PubMed:	Morierinin: a new cytotoxic cucurbitacin from the leaves of Morierina montana Vieill.
PubMed:	Antifeedant effects of proteinase inhibitors on feeding behaviors of adult western corn rootworm (Diabrotica virgifera virgifera).
PubMed:	Bioactive constituents of the roots of Licania intrapetiolaris.
PubMed:	Ecbalium elaterium (squirting cucumber)--remedy or poison?
PubMed:	Novel cytotoxic diterpenes from Casearia arborea.
PubMed:	Anti-inflammatory effects of the products from Wilbrandia ebracteata on carrageenan-induced pleurisy in mice.
PubMed:	Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor.
PubMed:	Anti-inflammatory and analgesic effects of cucurbitacins from Wilbrandia ebracteata.
PubMed:	Identification of sensilla involved in taste mediation in adult western corn rootworm (Diabrotica virgifera virgifera LeConte).
PubMed:	[Studies on the chemical constituents of Trichosanthes hupehensis C.Y. Cheng et Yueh].
PubMed:	A new cucurbitacin profile forCucurbita andreana: A candidate for cucurbitacin tissue culture.
PubMed:	New cucurbitacin glycosides from Picrorhiza kurrooa.
PubMed:	[Studies on the constituents of "Trichosanthes root". IV. Constituents of roots of Trichosanthes multiloba Miq., Trichosanthes miyagii Hay. and Chinese crude drug "karo-kon"].
PubMed:	[Studies on the constituents of trichosanthes root. III. Constituents of roots of Trichosanthes bracteata Voigt].
PubMed:	[Studies on the constituents of trichosanthes root. I. Constituents of roots of Trichosanthes kirilowii Maxim. var. japonicum Kitam].
PubMed:	Isolation of an anti-inflammatory principle from the fruit juice of Ecballium elaterium.
PubMed:	Disposition and fate of cucurbitacin B in five species of diabroticites.
PubMed:	Cucurbitacin B and isocucurbitacin B: cytotoxic components of Helicteres isora.
PubMed:	Plant anticancer agents. XXX: Cucurbitacins from Ipomopsis aggregata (Polemoniaceae).
PubMed:	Cucurbitacin B, the cytotoxic principle of Begonia tuberhybrida var. alba.
PubMed:	Cucurbitacin B delta 23-reductase from Cucurbita maxima. I. Assay methods, isolation and purification.
PubMed:	Cucurbitacin B delta 23-reductase from Cucurbita maxima. II. Cofactor requirements, enzyme kinetics, substrate specificity and other characteristics.
PubMed:	A thin-layer and an improved paper-chromatographic method for the separation of cucurbitacin B. and 23, 24-dihydrocucurbitacin B.
PubMed:	[THE DISTRIBUTION OF CUCURBITACINS AND CUCURBITACIN GLYCOSIDES IN THE GENUS IBERIS (CRUCIFERAE). ISOLATION OF CUCURBITACINS J AND K FROM IBERIS AMARA L. AND CUCURBITACIN B AND FROM IBERIS UMBELLATA L].