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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.9815 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Psoralidin 98%
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| BOC Sciences |
| For experimental / research use only. |
| Psoralidin >98%
Odor: characteristic Use: Psoralidin is a furanocoumarin natural product used in Chinese medicine. Psoralidin, a PTP1B inhibitor, has been shown to have anticancer activity with a variety of mechanisms proposed. Psoralidin induces ROS generation in androgen-independent prostate c |
| Sigma-Aldrich |
| For experimental / research use only. |
| Psoralidin ≥98% (HPLC)
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Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for psoralidin usage levels up to: | | | not for fragrance use.
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| Recommendation for psoralidin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 3,9-dihydroxy-2-(3-methylbut-2-enyl)-[1]benzofuro[3,2-c]chromen-6-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5281806 |
| Pubchem (cas): | 18642-23-4 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 6H- | benzofuro(3,2-c)(1)benzopyran-6-one, 3,9-dihydroxy-2-(3-methyl-2-butenyl)- | | 3,9- | dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro(3,2-c)(1)benzopyran-6-one | | 3,9- | dihydroxy-2-(3-methylbut-2-enyl)-[1]benzofuro[3,2-c]chromen-6-one |
Articles:
| PubMed: | Bavachalcone from Cullen corylifolium induces apoptosis and autophagy in HepG2 cells. |
| PubMed: | Plasma pharmacokinetics and cerebral nuclei distribution of major constituents of Psoraleae fructus in rats after oral administration. |
| PubMed: | Protective effects of psoralidin on IL‑1β‑induced chondrocyte apoptosis. |
| PubMed: | Rapid separation and simultaneous quantitative determination of 13 constituents in Psoraleae Fructus by a single marker using high-performance liquid chromatography with diode array detection. |
| PubMed: | Isoflavones and anti-inflammatory constituents from the fruits of Psoralea corylifolia. |
| PubMed: | Psoralidin suppresses osteoclastogenesis in BMMs and attenuates LPS-mediated osteolysis by inhibiting inflammatory cytokines. |
| PubMed: | Qualitative analysis of Psoraleae Fructus by HPLC-DAD/TOF-MS fingerprint and quantitative analysis of multiple components by single marker. |
| PubMed: | Inhibition of autophagy prevents cadmium-induced prostate carcinogenesis. |
| PubMed: | Psoralidin, a prenylated coumestan, as a novel anti-osteoporosis candidate to enhance bone formation of osteoblasts and decrease bone resorption of osteoclasts. |
| PubMed: | The Benzopyrone Biochanin-A as a reversible, competitive, and selective monoamine oxidase B inhibitor. |
| PubMed: | Targeting aberrant expression of Notch-1 in ALDH+cancer stem cells in breast cancer. |
| PubMed: | Synthesis of Psoralidin derivatives and their anticancer activity: First synthesis of Lespeflorin I1. |
| PubMed: | [Biosynthesis of a new psoralidin glucoside by enzymatic glycosylation]. |
| PubMed: | Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia. |
| PubMed: | Psoralidin inhibits proliferation and enhances apoptosis of human esophageal carcinoma cells via NF-κB and PI3K/Akt signaling pathways. |
| PubMed: | Comparison of the in vitro metabolism of psoralidin among different species and characterization of its inhibitory effect against UDP- glucuronosyltransferase (UGT) or cytochrome p450 (CYP450) enzymes. |
| PubMed: | Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells. |
| PubMed: | Nanoencapsulation of psoralidin via chitosan and Eudragit S100 for enhancement of oral bioavailability. |
| PubMed: | The molecular pathway of psoralidin-induced apoptosis in HepG2 cell line. |
| PubMed: | Quality Assessment of Psoralea fructus by HPLC Fingerprint Coupled with Multi-components Analysis. |
| PubMed: | Differential effect of psoralidin in enhancing apoptosis of colon cancer cells via nuclear factor-κB and B-cell lymphoma-2/B-cell lymphoma-2-associated X protein signaling pathways. |
| PubMed: | Inhibition behavior of fructus psoraleae's ingredients towards human carboxylesterase 1 (hCES1). |
| PubMed: | In vitro and in vivo assessment of the effect of antiprotozoal compounds isolated from Psoralea corylifolia against Ichthyophthirius multifiliis in fish. |
| PubMed: | Regio- and isoform-specific glucuronidation of psoralidin: evaluation of 3-o-glucuronidation as a functional marker for UGT1A9. |
| PubMed: | Plant-derived natural medicines for the management of depression: an overview of mechanisms of action. |
| PubMed: | Dealing naturally with stumbling blocks on highways and byways of TRAIL induced signaling. |
| PubMed: | Psoralidin induces autophagy through ROS generation which inhibits the proliferation of human lung cancer A549 cells. |
| PubMed: | Herb-drug interaction between irinotecan and psoralidin-containing herbs. |
| PubMed: | Psoralidin, a coumestan analogue, as a novel potent estrogen receptor signaling molecule isolated from Psoralea corylifolia. |
| PubMed: | [Chemical constituents from Psoralea corylifolia and their antioxidant alpha-glucosidase inhibitory and antimicrobial activities]. |
| PubMed: | Silencing NOTCH signaling causes growth arrest in both breast cancer stem cells and breast cancer cells. |
| PubMed: | [Study on effect of psoralidin on anti-experimental postmenopausal osteoporosis and its mechanism]. |
| PubMed: | Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro. |
| PubMed: | Psoralea corylifolia L. (Buguchi) - folklore to modern evidence: review. |
| PubMed: | Induction of reactive oxygen species generation inhibits epithelial-mesenchymal transition and promotes growth arrest in prostate cancer cells. |
| PubMed: | Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia. |
| PubMed: | The coumarin psoralidin enhances anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). |
| PubMed: | [Study on the chemical constituents of Psoralea corylifolia]. |
| PubMed: | [Variation of 4 kinds of compounds in Psoralea corylifolia processed by different methods]. |
| PubMed: | Retraction. Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells. |
| PubMed: | Psoralidin, a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation. |
| PubMed: | Enhanced TRAIL-mediated apoptosis in prostate cancer cells by the bioactive compounds neobavaisoflavone and psoralidin isolated from Psoralea corylifolia. |
| PubMed: | Psoralidin inhibits LPS-induced iNOS expression via repressing Syk-mediated activation of PI3K-IKK-IκB signaling pathways. |
| PubMed: | Activating stress-activated protein kinase-mediated cell death and inhibiting epidermal growth factor receptor signaling: a promising therapeutic strategy for prostate cancer. |
| PubMed: | Isolation of antioxidants from Psoralea corylifolia fruits using high-speed counter-current chromatography guided by thin layer chromatography-antioxidant autographic assay. |
| PubMed: | Inhibiting TNF-mediated signaling: a novel therapeutic paradigm for androgen independent prostate cancer. |
| PubMed: | Induction of quinone reductase activity by psoralidin isolated from Psoralea corylifolia in mouse hepa 1c1c7 cells. |
| PubMed: | Total synthesis of psoralidin, an anticancer natural product. |
| PubMed: | Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells. |
| PubMed: | Bioactive constituents from Chinese natural medicines. XXXIII. Inhibitors from the seeds of Psoralea corylifolia on production of nitric oxide in lipopolysaccharide-activated macrophages. |
| PubMed: | [Studies on chemical constituents from seed of Psoralea corylifolia]. |
| PubMed: | Transcriptional regulation of corticotrophin releasing factor gene by furocoumarins isolated from seeds of Psoralea corylifolia. |
| PubMed: | Antidepressant-like effects of psoralidin isolated from the seeds of Psoralea Corylifolia in the forced swimming test in mice. |
| PubMed: | Chemical fingerprint and quantitative analysis of fructus psoraleae by high-performance liquid chromatography. |
| PubMed: | Bioactive constituents from Chinese natural medicines. XX. Inhibitors of antigen-induced degranulation in RBL-2H3 cells from the seeds of Psoralea corylifolia. |
| PubMed: | [Isolation and structure identification of a new isoflavone from Psoralea corylifolias]. |
| PubMed: | Fingerprint analysis of Psoralea corylifolia L. by HPLC and LC-MS. |
| PubMed: | In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia. |
| PubMed: | Antibacterial compounds from the seeds of Psoralea corylifolia. |
| PubMed: | Cytotoxic constituents of Psoralea corylifolia. |
| PubMed: | The cytotoxicity of psoralidin from Psoralea corylifolia. |
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