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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 7.872 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Panaxydol > 95%
Odor: characteristic Use: Panaxydol, extracted from the roots of Panax ginseng C. A. Mey, inhibits the growth of cancer cells through EGFR activation and ER stress. |
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for panaxydol usage levels up to: | | | not for fragrance use.
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| Recommendation for panaxydol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (3R)-8-[(2R,3S)-3-heptyloxiran-2-yl]oct-1-en-4,6-diyn-3-ol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 126312 |
| Pubchem (cas): | 72800-72-7 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (3R)-8-[(2R,3S)-3- | heptyloxiran-2-yl]oct-1-en-4,6-diyn-3-ol | | 1- | octene-4,6-diyn-3-ol, 8-(3-heptyloxiranyl)- |
Articles:
| PubMed: | Inhibitory Effects of Polyacetylene Compounds from Panax ginseng on Neurotrophin Receptor-Mediated Hair Growth. |
| PubMed: | Isolation and characterization of bioactive polyacetylenes Panax ginseng Meyer roots. |
| PubMed: | Determining the mode of action of anti-mycobacterial C17 diyne natural products using expression profiling: evidence for fatty acid biosynthesis inhibition. |
| PubMed: | Panaxydol, a component of Panax ginseng, induces apoptosis in cancer cells through EGFR activation and ER stress and inhibits tumor growth in mouse models. |
| PubMed: | Gas chromatography/mass spectrometry-based metabolic profiling and differentiation of ginseng roots according to cultivation age using variable selection. |
| PubMed: | Biosynthesis of panaxynol and panaxydol in Panax ginseng. |
| PubMed: | Anti-mycobacterial diynes from the Canadian medicinal plant Aralia nudicaulis. |
| PubMed: | [Simultaneous determination of panaxynol and panaxydol in fibrous root of Panax ginseng by HPLC]. |
| PubMed: | Induction of apoptosis in human promyelocytic leukemia HL60 cells by panaxynol and panaxydol. |
| PubMed: | Induction of differentiation by panaxydol in human hepatocarcinoma SMMC-7721 cells via cAMP and MAP kinase dependent mechanism. |
| PubMed: | Panaxydol induces apoptosis through an increased intracellular calcium level, activation of JNK and p38 MAPK and NADPH oxidase-dependent generation of reactive oxygen species. |
| PubMed: | Quantitative comparison of ginsenosides and polyacetylenes in wild and cultivated American ginseng. |
| PubMed: | Differential effects of falcarinol and related aliphatic C(17)-polyacetylenes on intestinal cell proliferation. |
| PubMed: | Panaxydol inhibits the proliferation and induces the differentiation of human hepatocarcinoma cell line HepG2. |
| PubMed: | Rapid method for simultaneous determination of flavonoid, saponins and polyacetylenes in folium ginseng and radix ginseng by pressurized liquid extraction and high-performance liquid chromatography coupled with diode array detection and mass spectrometry. |
| PubMed: | Phosphatidylinositol 3-kinase activity is required for the induction of differentiation in C6 glioma cells by panaxydol. |
| PubMed: | Biomass and content of ginsenosides and polyacetylenes in American ginseng roots can be increased without affecting the profile of bioactive compounds. |
| PubMed: | Cyclic AMP-dependent regulation of differentiation of rat C6 glioma cells by panaxydol. |
| PubMed: | Panaxydol treatment enhances the biological properties of Schwann cells in vitro. |
| PubMed: | Effect of panaxydol on hypoxia-induced cell death and expression and secretion of neurotrophic factors (NTFs) in hypoxic primary cultured Schwann cells. |
| PubMed: | Polyacetylenes from the roots of cultivated-wild ginseng and their cytotoxicity in vitro. |
| PubMed: | Panaxydol and panaxynol protect cultured cortical neurons against Abeta25-35-induced toxicity. |
| PubMed: | Growth inhibition and induction of differentiation by panaxydol in rat C6 glioma cells. |
| PubMed: | Quantification of two polyacetylenes in Radix Ginseng and roots of related Panax species using a gas chromatography-mass spectrometric method. |
| PubMed: | Induction of apoptosis in rat C6 glioma cells by panaxydol. |
| PubMed: | Simultaneous determination of ginsenosides and polyacetylenes in American ginseng root (Panax quinquefolium L.) by high-performance liquid chromatography. |
| PubMed: | Structural changes of polyacetylenes in American ginseng root can be observed in situ by using Raman spectroscopy. |
| PubMed: | Protective effect of panaxydol and panaxynol on sodium nitroprusside-induced apoptosis in cortical neurons. |
| PubMed: | Polyacetylenes in hairy roots of a panax hybrid. |
| PubMed: | Determination of polyacetylenes and ginsenosides in Panax species using high performance liquid chromatography. |
| PubMed: | Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium. |
| PubMed: | Induction of G(1) cell cycle arrest and p27(KIP1) increase by panaxydol isolated from Panax ginseng. |
| PubMed: | Synthesis of ginseng diyne analogues and their antiproliferative activity against L1210 cells. |
| PubMed: | Effect of petroleum ether extract of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cells. |
| PubMed: | Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit Acyl-CoA : cholesterol acyltransferase. |
| PubMed: | Screening of polyacetylenic alcohols in crude drugs using the ELISA for panaxytriol. |
| PubMed: | [Relationship between antiproliferative activity of acetylenic alcohol, panaxydol, and its affinity for target cell membrane]. |
| PubMed: | The first specific antibody against cytotoxic polyacetylenic alcohol, panaxynol. |
| PubMed: | Cytotoxic activity of polyacetylene compounds in Panax ginseng C. A. Meyer. |
| PubMed: | [Acetylpanaxydol and panaxydolchlorohydrin, two new polyenes from Korean ginseng with cytotoxic activity against L1210 cells]. |
| PubMed: | [Relation between structure and cytotoxic activity of panaxydol analogs against L1210 cells]. |
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