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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.02918 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for liensinine usage levels up to: | | | not for fragrance use.
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| Recommendation for liensinine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 160644 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | 4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol |
| Chemidplus: | 0002586961 |
References:
| | 4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 160644 |
| Pubchem (cas): | 2586-96-1 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4-[[(1R)-6,7- | dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol | | | phenol, 4-((1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)methyl)-2-((1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-6-methoxy-2-methyl-7-isoquinolinyl)oxy)-, (R-(R*,R*))- |
Articles:
| PubMed: | Liensinine and Nuciferine, Bioactive Components ofNelumbo nucifera, Inhibit the Growth of Breast Cancer Cells and Breast Cancer-Associated Bone Loss. |
| PubMed: | [Studies on the chemical components of Nelumbinis Plumula and the inhibitory activity on protein disulfide isomerase]. |
| PubMed: | Isolation and identification of a tribenzylisoquinoline alkaloid from Nelumbo nucifera Gaertn, a novel potential smooth muscle relaxant. |
| PubMed: | A general ionic liquid pH-zone-refining countercurrent chromatography method for separation of alkaloids from Nelumbo nucifera Gaertn. |
| PubMed: | Effects of diacetyl-liensinine on electrophysiology in rabbit ventricular myocytes. |
| PubMed: | Initial autophagic protection switches to disruption of autophagic flux by lysosomal instability during cadmium stress accrual in renal NRK-52E cells. |
| PubMed: | Development and Characterization Pulsatile Microspheres of Nifedipine for Hypertension. |
| PubMed: | Investigation of G-quadruplex formation in the FGFR2 promoter region and its transcriptional regulation by liensinine. |
| PubMed: | A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development. |
| PubMed: | [Metabolites Identification for Alkaloids from Nelumbinis Plumula in Caco-2 Cells by LC/MS/MS]. |
| PubMed: | Liensinine- and Neferine-Induced Cardiotoxicity in Primary Neonatal Rat Cardiomyocytes and Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. |
| PubMed: | Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers. |
| PubMed: | Serotonergic mechanisms are involved in antidepressant-like effects of bisbenzylisoquinolines liensinine and its analogs isolated from the embryo of Nelumbo nucifera Gaertner seeds in mice. |
| PubMed: | Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation. |
| PubMed: | A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission. |
| PubMed: | Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids from Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements. |
| PubMed: | Quantification of liensinine in rat plasma using ultra-performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. |
| PubMed: | A simple U-HPLC-MS/MS method for the determination of liensinine and isoliensinine in rat plasma. |
| PubMed: | Simultaneous determination of liensinine, isoliensinine and neferine in rat plasma by UPLC-MS/MS and application of the technique to pharmacokinetic studies. |
| PubMed: | BACE1 and cholinesterase inhibitory activities of Nelumbo nucifera embryos. |
| PubMed: | Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells. |
| PubMed: | Protective effects of alkaloid compounds from Nelumbinis Plumula on tert-butyl hydroperoxide-induced oxidative stress. |
| PubMed: | In vitro characterization of ABC transporters involved in the absorption and distribution of liensinine and its analogs. |
| PubMed: | The interaction between human breast cancer resistance protein (BCRP) and five bisbenzylisoquinoline alkaloids. |
| PubMed: | [Effect of berberine, liensinine and neferine on HERG channel expression]. |
| PubMed: | Simultaneous separation, identification and activity evaluation of three butyrylcholinesterase inhibitors from Plumula nelumbinis using on-line HPLC-UV coupled with ESI-IT-TOF-MS and BChE biochemical detection. |
| PubMed: | Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera. |
| PubMed: | Comparative effects of liensinine and neferine on the human ether-a-go-go-related gene potassium channel and pharmacological activity analysis. |
| PubMed: | Rapid determination of three alkaloids from Lotus Plumule in human serum using an HPLC-DAD method with a short monolithic column. |
| PubMed: | Simultaneous determination of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn. in rat plasma by a rapid HPLC method and its application to a pharmacokinetic study. |
| PubMed: | Bisbenzylisoquinoline Alkaloids from Nelumbo nucifera. |
| PubMed: | Semi-preparative high-speed counter-current chromatography separation of alkaloids from embryo of the seed of Nelumbo nucifera Gaertn by pH-gradient elution. |
| PubMed: | Preparative separation of alkaloids from Nelumbo nucifera Gaertn by pH-zone-refining counter-current chromatography. |
| PubMed: | Preparative separation and purification of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera GAERTN using high-speed counter-current chromatography. |
| PubMed: | [Metabolic products and pathway of neferine in rat liver]. |
| PubMed: | [Determination of three alkaloids in total alkaloids exfracts from Lotus plumule by RP-HPLC]. |
| PubMed: | Pharmacokinetics and metabolism of neferine in rats after a single oral administration. |
| PubMed: | [Study on preparation technology of plumula nelumbinis Alkaloid Dripping Pill and determination of content by HPLC]. |
| PubMed: | Fragmentation study on the phenolic alkaloid neferine and its analogues with anti-HIV activities by electrospray ionization tandem mass spectrometry with hydrogen/deuterium exchange and its application for rapid identification of in vitro microsomal metabolites of neferine. |
| PubMed: | Separation, identification and rapid determination of liensine, isoliensinine and neferine from embryo of the seed of Nelumbo nucifera Gaertn. by liquid chromatography coupled to diode array detector and tandem mass spectrometry. |
| PubMed: | Inhibitory effects of isoliensinine on bleomycin-induced pulmonary fibrosis in mice. |
| PubMed: | Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids. |
| PubMed: | Preparative counter-current chromatography isolation of liensinine and its analogues from embryo of the seed of Nelumbo nucifera GAERTN. using upright coil planet centrifuge with four multilayer coils connected in series. |
| PubMed: | [Determination of liensinine in plasma by high performance liquid chromatography]. |
| PubMed: | [Stability of liensinine injection]. |
| PubMed: | [Quantitative determination of liensinine in the embryo Nelumbinis (Nelumbo nucifera Gaertn.) by TLC-scanning]. |
| PubMed: | [Effects of linesinine on slow action potentials in myocardium and slow inward current in canine cardiac Purkinje fibers]. |
| PubMed: | [Pharmacokinetics of liensinine in rabbits]. |
| PubMed: | [Effects of liensinine on haemodynamics in rats and the physiologic properties of isolated rabbit atria]. |
| PubMed: | [Alkaloids of plumula Nelumbinis]. |
| PubMed: | [Studies on the alkaloids of Nelumbo nucifera Gaertn. NMR spectra of liensinine type alkaloids]. |
| PubMed: | Bisbenzylisoquinoline alkaloids and related compounds. V. A total synthesis of diastereoisomeric mixture of liensinine. |
| PubMed: | STUDIES ON THE ALKALOIDS OF EMBRYO LOTI, NELEMBO NUCIFERA GAERTIN. IV. TOTAL SYNTHESIS OF LIENSININE. |
| PubMed: | STUDIES ON THE ALKALOIDS OF EMBRYO LOTI, NELEMBO NUCIFERA GAERTIN. 3. ABSOLUTE CONFIGURATION OF LIENSININE. |
| PubMed: | [HYPOTENSIVE ACTION OF LIENSININE AND ITS TWO DERIVATIVES]. |
| PubMed: | Studies on the alkaloids of embryo loti, Nelumbo nucifera Gaertn. I. Isolation and characterisation of liensinine. |
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