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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.01748 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| Isoliensinine 98%
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| BOC Sciences |
| For experimental / research use only. |
| isoliensinine >98%
Odor: characteristic Use: Isoliensinine, a natural phenolic bisbenzyltetrahydroisoquinoline alkaloid, has received considerable attention for its potential biological effects such as antioxidant and anti-HIV activities. It possesses an anti-proliferative effect. |
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for isoliensinine usage levels up to: | | | not for fragrance use.
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| Recommendation for isoliensinine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5274591 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | (1R)-1-[[4-hydroxy-3-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol |
| Chemidplus: | 0006817410 |
References:
| | (1R)-1-[[4-hydroxy-3-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5274591 |
| Pubchem (cas): | 6817-41-0 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (1R)-1-[[4- | hydroxy-3-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol | | 7-iso | quinolinol, 1,2,3,4-tetrahydro-1-((4-hydroxy-3-((1,2,3,4-tetrahydro-6-methoxy-1-((4-methoxyphenyl)methyl)-2-methyl-7-isoquinolinyl)oxy)phenyl)methyl)-6-methoxy-2-methyl-, (R-(R*,R*))- |
Articles:
| PubMed: | [Studies on the chemical components of Nelumbinis Plumula and the inhibitory activity on protein disulfide isomerase]. |
| PubMed: | Isolation and identification of a tribenzylisoquinoline alkaloid from Nelumbo nucifera Gaertn, a novel potential smooth muscle relaxant. |
| PubMed: | Activity of Isoliensinine in Improving the Symptoms of Type 2 Diabetic Mice via Activation of AMP-Activated Kinase and Regulation of PPARγ. |
| PubMed: | A general ionic liquid pH-zone-refining countercurrent chromatography method for separation of alkaloids from Nelumbo nucifera Gaertn. |
| PubMed: | K-targeted strategy for isolation of phenolic alkaloids of Nelumbo nucifera Gaertn by counter-current chromatography using lysine as a pH regulator. |
| PubMed: | Glucocorticoid-Induced Leucine Zipper Suppresses ICAM-1 and MCP-1 Expression by Dephosphorylation of NF-κB p65 in Retinal Endothelial Cells. |
| PubMed: | Anti-ageing active ingredients from herbs and nutraceuticals used in traditional Chinese medicine: pharmacological mechanisms and implications for drug discovery. |
| PubMed: | Isoliensinine induces dephosphorylation of NF-kB p65 subunit at Ser536 via a PP2A-dependent mechanism in hepatocellular carcinoma cells: roles of impairing PP2A/I2PP2A interaction. |
| PubMed: | A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development. |
| PubMed: | [Metabolites Identification for Alkaloids from Nelumbinis Plumula in Caco-2 Cells by LC/MS/MS]. |
| PubMed: | Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers. |
| PubMed: | Isoliensinine, a Bioactive Alkaloid Derived from Embryos of Nelumbo nucifera, Induces Hepatocellular Carcinoma Cell Apoptosis through Suppression of NF-κB Signaling. |
| PubMed: | Serotonergic mechanisms are involved in antidepressant-like effects of bisbenzylisoquinolines liensinine and its analogs isolated from the embryo of Nelumbo nucifera Gaertner seeds in mice. |
| PubMed: | Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation. |
| PubMed: | A simple U-HPLC-MS/MS method for the determination of liensinine and isoliensinine in rat plasma. |
| PubMed: | Simultaneous determination of liensinine, isoliensinine and neferine in rat plasma by UPLC-MS/MS and application of the technique to pharmacokinetic studies. |
| PubMed: | Natural small-molecule enhancers of autophagy induce autophagic cell death in apoptosis-defective cells. |
| PubMed: | Comparative analysis of antioxidant activity and functional components of the ethanol extract of lotus (Nelumbo nucifera) from various growing regions. |
| PubMed: | Protective effects of alkaloid compounds from Nelumbinis Plumula on tert-butyl hydroperoxide-induced oxidative stress. |
| PubMed: | In vitro characterization of ABC transporters involved in the absorption and distribution of liensinine and its analogs. |
| PubMed: | Analysis of alkaloids in Lotus (Nelumbo nucifera Gaertn.) leaves by non-aqueous capillary electrophoresis using ultraviolet and mass spectrometric detection. |
| PubMed: | The interaction between human breast cancer resistance protein (BCRP) and five bisbenzylisoquinoline alkaloids. |
| PubMed: | Simultaneous separation, identification and activity evaluation of three butyrylcholinesterase inhibitors from Plumula nelumbinis using on-line HPLC-UV coupled with ESI-IT-TOF-MS and BChE biochemical detection. |
| PubMed: | Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera. |
| PubMed: | Identification of three new N-demethylated and O-demethylated bisbenzylisoquinoline alkaloid metabolites of isoliensinine from dog hepatic microsomes. |
| PubMed: | [Influence of isoliensinine on activity of CYP3A in rats]. |
| PubMed: | Rapid determination of three alkaloids from Lotus Plumule in human serum using an HPLC-DAD method with a short monolithic column. |
| PubMed: | Simultaneous determination of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera Gaertn. in rat plasma by a rapid HPLC method and its application to a pharmacokinetic study. |
| PubMed: | Bisbenzylisoquinoline Alkaloids from Nelumbo nucifera. |
| PubMed: | Semi-preparative high-speed counter-current chromatography separation of alkaloids from embryo of the seed of Nelumbo nucifera Gaertn by pH-gradient elution. |
| PubMed: | Preparative separation of alkaloids from Nelumbo nucifera Gaertn by pH-zone-refining counter-current chromatography. |
| PubMed: | Preparative separation and purification of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera GAERTN using high-speed counter-current chromatography. |
| PubMed: | [Metabolic products and pathway of neferine in rat liver]. |
| PubMed: | [Determination of three alkaloids in total alkaloids exfracts from Lotus plumule by RP-HPLC]. |
| PubMed: | Pharmacokinetics and metabolism of neferine in rats after a single oral administration. |
| PubMed: | [Study on preparation technology of plumula nelumbinis Alkaloid Dripping Pill and determination of content by HPLC]. |
| PubMed: | Fragmentation study on the phenolic alkaloid neferine and its analogues with anti-HIV activities by electrospray ionization tandem mass spectrometry with hydrogen/deuterium exchange and its application for rapid identification of in vitro microsomal metabolites of neferine. |
| PubMed: | Effects of isoliensinine on angiotensin II-induced proliferation of porcine coronary arterial smooth muscle cells. |
| PubMed: | Separation, identification and rapid determination of liensine, isoliensinine and neferine from embryo of the seed of Nelumbo nucifera Gaertn. by liquid chromatography coupled to diode array detector and tandem mass spectrometry. |
| PubMed: | Effects of isoliensinine on proliferation of porcine coronary arterial smooth muscle cells induced by phenylephrine. |
| PubMed: | Inhibitory effects of isoliensinine on bleomycin-induced pulmonary fibrosis in mice. |
| PubMed: | Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids. |
| PubMed: | NMR spectroscopic analysis of neferine and isoliensinine. |
| PubMed: | Preparative counter-current chromatography isolation of liensinine and its analogues from embryo of the seed of Nelumbo nucifera GAERTN. using upright coil planet centrifuge with four multilayer coils connected in series. |
| PubMed: | [Alkaloids of plumula Nelumbinis]. |
| PubMed: | A total synthesis of isoliensinine. |
| PubMed: | On the alkaloids of Nelumbo nucifera Gaertn. 8. Studies on the alkaloids of loti embryo. 1. Structure of isoliensinine, a new biscoclaurine type alkaloid. |
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