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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 235.3 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Aegeline > 95%
Odor: characteristic Use: Aegeline, is a compound that can be extracted from Aegle marmelos leaves, a tree that grows in India. Research has found the essential oil of the tree to be effective against 21 types of bacteria. Aegeline, has also shown to have anti-obesity effects. |
| TCI AMERICA |
| For experimental / research use only. |
| (±)-Aegeline >98.0%(HPLC)(N)
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Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for (±)-aegeline usage levels up to: | | | not for fragrance use.
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| Recommendation for (±)-aegeline flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | (E)-N-[2-hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 15558419 |
| Pubchem (cas): | 456-12-2 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| N-(2- | hydroxy-2(4-methoxyphenyl)ethyl)-3-phenyl-2-propenamide, (E)- | | (E)-N-[2- | hydroxy-2-(4-methoxyphenyl)ethyl]-3-phenylprop-2-enamide | | 2- | propenamide, N-(2-hydroxy-2-(4-methoxyphenyl)ethyl)-3-phenyl-, (E)- |
Articles:
| PubMed: | Pharmacokinetics and Tissue Distribution of Aegeline after Oral Administration in Mice |
| PubMed: | Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs) |
| PubMed: | Aegeline from Aegle marmelos stimulates glucose transport via Akt and Rac1 signaling, and contributes to a cytoskeletal rearrangement through PI3K/Rac1 |
| PubMed: | Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing à-synuclein and Bax toxicity in yeast |
| PubMed: | Aegeline inspired synthesis of novel amino alcohol and thiazolidinedione hybrids with antiadipogenic activity in 3T3-L1 cells |
| PubMed: | Simultaneous Determination of Aegeline and Six Coumarins from Different Parts of the Plant Aegle marmelos Using UHPLC-PDA-MS and Chiral Separation of Aegeline Enantiomers Using HPLC-ToF-MS |
| PubMed: | Aegeline inspired synthesis of novel ?3-AR agonist improves insulin sensitivity in vitro and in vivo models of insulin resistance |
| PubMed: | LOX-1, the Common Therapeutic Target in Hypercholesterolemia: A New Perspective of Antiatherosclerotic Action of Aegeline |
| PubMed: | Corrigendum to "Aegeline, a natural product from the plant Aegle marmelos, mimics the yeast SNARE protein Sec22p in suppressing à-synuclein and Bax toxicity in yeast" [Bioorg. Med. Chem. Lett. 29 (2019) 454-460] |
| PubMed: | Effects of aegeline, a main alkaloid of Aegle Marmelos Correa leaves, on the histamine release from mast cells |
| PubMed: | Inhibition of CYP3A4 and CYP1A2 by Aegle marmelos and its constituents |
| PubMed: | Lipid lowering agents of natural origin: An account of some promising chemotypes |
| PubMed: | Antihyperglycemic and antidyslipidemic agent from Aegle marmelos |
| PubMed: | Interaction of active compounds from Aegle marmelos CORREA with histamine-1 receptor |
| PubMed: | The Role of Adverse Event Reporting in the FDA Response to a Multistate Outbreak of Liver Disease Associated with a Dietary Supplement |
| PubMed: | Two new cytotoxic furoquinoline alkaloids isolated from Aegle marmelos (Linn.) Correa |
| PubMed: | Synthesis of novel N-(2-hydroxy-2-p-tolylethyl)-amide and N-(2-oxo-2-p-tolylethyl)-amide derivatives and their antidyslipidemic and antioxidant activity |
| PubMed: | Synthesis of new N-acryl-1-amino-2-phenylethanol and N-acyl-1-amino-3-aryloxypropanols and evaluation of their antihyperlipidemic, LDL-oxidation and antioxidant activity |
| PubMed: | Anti adipogenic activity of Aegle marmelos Correa |
| PubMed: | Biological Evaluation of Aegle marmelos Fruit Extract and Isolated Aegeline in Alleviating Pain-Depression Dyad: In Silico Analysis of Aegeline on MAO-A and iNOS |
| PubMed: | ACTION OF RANEY NICKEL ON AEGELINE, AEGELONE AND DIHYDROAEGELINE |
| PubMed: | Outbreak of severe hepatitis linked to weight-loss supplement OxyELITE Pro |
| PubMed: | Hydrosoluble formazan XTT: its application to natural products drug discovery for Leishmania |
| PubMed: | Severe Acute Hepatocellular Injury Attributed to OxyELITE Pro: A Case Series |
| PubMed: | Binolam-AlCl: a two-centre catalyst for the synthesis of enantioenriched cyanohydrin O-phosphates |
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