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poloxamer
Notes:
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BOC Sciences Best of Chemicals Supplier Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. BOC Sciences provides a wide range of services to support the pharmaceutical industry through all stages of drug discovery including Custom Synthesis of those chemicals that are not in stock, Isotope Labeling Service, Chiral Synthesis and Resolution, Bioconjugation, PEGylation services, analytical services. BOC Sciences is a brand of BOCSCI Inc. We leverage our wide spectrum of business in the fields of development, manufacturing, marketing, and distribution to help you make best-informed decisions tailored to your evolving needs for premium chemicals. Our complete suite of CRO services spans the entire molecule development pipeline including contract research for target identification, building blocks, compound synthesis, biochemical and cellular analysis, preclinical animal tests, and clinical studies. Email: Marketing US Email: Marketing Email: Sales US Email: Sales Voice: 1-631-485-4226 Fax: 1-631-614-7828 US Voice: 1-631-485-4226 US Fax: 1-631-614-7828 Europe 44-203-286-1088 Facebook Twitter Linkedin Blog Get the App! Product(s): 106392-12-5 Poloxamer
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| CAS Number: | 106392-12-5 |  3D/inchi
|
| Other(deleted CASRN): | 11104-97-5 | |
| Molecular Weight: | 102.13310000 | |
| Formula: | C5 H10 O2 | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: indirect food additives: adhesives and components of coatings
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
| FDA Mainterm (SATF): | 9003-11-6 ; ETHYLENE OXIDE/PROPYLENE OXIDE COPOLYMER |
| FDA Mainterm (IAUFC): | 9003-11-6 ; POLY(ETHYLENE OXIDE-CO-PROPYLENE OXIDE), BLOCK |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Poloxamer |
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intraperitoneal-mouse LD50 420 mg/kg Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982. intravenous-mouse LD50 129 mg/kg Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 569, 1993. intravenous-mouse LD50 1000 mg/kg Microvascular Research. Vol. 8, Pg. 320, 1974. intravenous-mouse LD50 3000 mg/kg Drugs in Japan Vol. 6, Pg. 797, 1982. oral-mouse LD50 > 30300 ug/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 2291, 1981. oral-mouse LD50 1830 mg/kg Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982. oral-mouse LD50 15000 mg/kg Bollettino Chimico Farmaceutico. Vol. 101, Pg. 173, 1962. unreported-mouse LD50 400 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 530 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 750 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 830 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 1250 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 1400 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 2250 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 2700 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 3000 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 3750 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 4200 mg/kg United States Patent Document. Vol. #4043344 unreported-mouse LD50 > 5000 mg/kg United States Patent Document. Vol. #4043344 intraperitoneal-rat LD50 320 mg/kg LIVER: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA National Technical Information Service. Vol. OTS0540972 intraperitoneal-rat LD50 1140 mg/kg Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982. intravenous-rat LD50 7500 mg/kg Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981. oral-rat LD50 > 30300 ug/kg Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 23, Pg. 2291, 1981. oral-rat LD50 2300 mg/kg Journal of Pharmacy and Pharmacology. Vol. 34(Suppl), Pg. 533, 1982. oral-rat LD50 5000 mg/kg LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION Wyandotte Chemicals Corporation Reports. oral-rat LD50 9380 mg/kg "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 297, 1972. oral-rat LD50 22400 mg/kg Union Carbide Data Sheet. Vol. 7/14/1965 | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 5500 mg/kg Drugs in Japan Vol. 6, Pg. 797, 1982. skin-rabbit LD50 > 5000 mg/kg Union Carbide Data Sheet. Vol. 7/14/1965 subcutaneous-rat LD50 6900 mg/kg Drugs in Japan Vol. 6, Pg. 797, 1982. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | indirect food additives: adhesives and components of coatings | ||
| Recommendation for ethylene oxide/propylene oxide copolymer usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for ethylene oxide/propylene oxide copolymer flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 24751 |
| National Institute of Allergy and Infectious Diseases: | Data |
| 2-methyloxirane;oxirane | |
| Chemidplus: | 0106392125 |
References:
| 2-methyloxirane;oxirane | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 24751 |
| Pubchem (cas): | 106392-12-5 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| FDA Indirect Additives used in Food Contact Substances: | View |
| CHEBI: | View |
| KEGG (GenomeNet): | D01941 |
| HMDB (The Human Metabolome Database): | HMDB32263 |
| FooDB: | FDB009380 |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| methyloxirane polymer with oxirane block | |
| 2- | methyloxirane;oxirane |
| poloxalene | |
| poloxamer | |
| polyoxyethylene - polyoxypropylene block copolymer | |
| propylene oxide ethylene oxide block polymer |