euphol
eupha-8,24-dienol
 
Notes:
None found
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    • BOC Sciences
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      Product(s):
      514-47-6 Euphol >98%
      Source from spurge, euphorbia kansui anti-hypertension
       
       
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CAS Number: 514-47-6Picture of molecule3D/inchi
Nikkaji Web: J14.838E
Beilstein Number: 3596105
XlogP3-AA: 8.90 (est)
Molecular Weight: 426.72770000
Formula: C30 H50 O
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Soluble in:
 water, 4.105e-006 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Alfa Biotechnology
For experimental / research use only.
Euphadienol 98%
BOC Sciences
For experimental / research use only.
Euphol >98%
Odor: characteristic
Use: Source from spurge, euphorbia kansui anti-hypertension
ExtraSynthese
For experimental / research use only.
Euphol Purity (HPLC) ≥90%
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for euphol usage levels up to:
 not for fragrance use.
 
Recommendation for euphol flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 441678
National Institute of Allergy and Infectious Diseases: Data
 (3S,5R,10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
Chemidplus: 0000514476
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References:
 (3S,5R,10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 441678
Pubchem (cas): 514-47-6
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEBI: View
CHEMBL: View
KEGG (GenomeNet): C08624
HMDB (The Human Metabolome Database): HMDB31438
FooDB: FDB004483
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 vitellaria paradoxa seed oil
Search Trop  Picture
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Synonyms:
 eupha-8,24-dienol
13-alpha,14-beta,17-beta-H-lanosta-8,24-dien-3-beta-ol (7CI,8CI)
(3S,5R,10S,13S,14S,17S)-4,4,10,13,14-pentamethyl-17-[(2R)-6-methylhept-5-en-2-yl]-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
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Articles:
PubMed: Comparative Transcriptome Analysis Identifies Putative Genes Involved in Steroid Biosynthesis in Euphorbia tirucalli.
PubMed: [Acute toxicity of Euphorbiae Pekinensis Radix and vinegar-processing Euphorbiae Pekinensis Radix on zebrafish embryo].
PubMed: Anti-HIV activity of southern African plants: Current developments, phytochemistry and future research.
PubMed: Euphorbia neriifolia L.: Review on botany, ethnomedicinal uses, phytochemistry and biological activities.
PubMed: Antibacterial activities of the methanol extract, fractions and compounds from Elaeophorbia drupifera (Thonn.) Stapf. (Euphorbiaceae).
PubMed: Cytotoxic biomonitored study of Euphorbia umbellata (Pax) Bruyns.
PubMed: Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts.
PubMed: The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε.
PubMed: Chemical Constituents from the Leaves of Euphorbia ammak Growing in Saudi Arabia.
PubMed: [Chemical constituents from Euphorbia lunulata].
PubMed: Quantitative determination of euphol in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.
PubMed: Chemical and pharmacological investigation of the stem bark of Synadenium grantii.
PubMed: Minor ent-abietane diterpenoids from Euphorbia guyoniana.
PubMed: Antitumoural effect of Synadenium grantii Hook f. (Euphorbiaceae) latex.
PubMed: Euphol arrests breast cancer cells at the G1 phase through the modulation of cyclin D1, p21 and p27 expression.
PubMed: Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae).
PubMed: Bio-guided isolation of the cytotoxic terpenoids from the roots of Euphorbia kansui against human normal cell lines L-O2 and GES-1.
PubMed: The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice.
PubMed: [Optimization of vinegar processing technique of Euphorbia pekinensis by multi-index orthogonal test].
PubMed: Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis.
PubMed: Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: the involvement of cannabinoid system.
PubMed: Euphol prevents experimental autoimmune encephalomyelitis in mice: evidence for the underlying mechanisms.
PubMed: Preventive and therapeutic euphol treatment attenuates experimental colitis in mice.
PubMed: Antileishmanial and antitrypanosomal activity of triterpene derivatives from latex of two Euphorbia species.
PubMed: [Anti-HBV constituents from Euphorbia fischeriana].
PubMed: Antimicrobial activities of the methanol extract, fractions and compounds from Ficus polita Vahl. (Moraceae).
PubMed: Discovery of potent and reversible monoacylglycerol lipase inhibitors.
PubMed: Bioactive triterpene derivatives from latex of two Euphorbia species.
PubMed: [Study on chemical constituents of Euphorbia hylonoma hand. -Mazz].
PubMed: [Studies on constituents from roots of Euphorbia hylonoma].
PubMed: [Studies on chemical constitutes of green alga Chaetomorpha basiretorsa and their bioactivity].
PubMed: Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3beta-ol and bacchar-12-en-3beta-ol by recombinant beta-amyrin synthase.
PubMed: A new tetracyclic triterpene from the latex of Euphorbia nerifolia.
PubMed: Euphane and tirucallane triterpenes from the roots of Euphorbia kansui and their in vitro effects on the cell division of Xenopus.
PubMed: Eupha-7,9(11),24-trien-3beta-ol ("antiquol C") and other triterpenes from Euphorbia antiquorum latex and their inhibitory effects on Epstein-Barr virus activation.
PubMed: Inhibitory effect of euphol, a triterpene alcohol from the roots of Euphorbia kansui, on tumour promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
PubMed: Triterpene alcohols from camellia and sasanqua oils and their anti-inflammatory effects.
PubMed: [Triterpene constituents from Euphorbia nematocypha Hand-Mazz].
PubMed: Analysis of a thread used in the Kshara Sutra treatment in the Ayurvedic medicinal system.
PubMed: Hypotensive activity of 8,24-euphadien-3 beta-ol (euphol).
PubMed: Studies in the Chemical Constituents of Azadirachta indica Part II: Isolation and Structure of the New Triterpenoid Azadirachtol.
PubMed: Rotational isomerism about the 17(20)-bond of steroids and euphoids as shown by the crystal structures of euphol and tirucallol.
PubMed: [Studies on the constituents of Chinese drug "kanzui." 8. KMnO4 oxidation of euphol, tirucallol and beta-euphorbol].
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