|
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.02371 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for punicic acid usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for punicic acid flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (9Z,11E,13Z)- | octadeca-9,11,13-trienoic acid | | 9Z,11E,13Z- | octadeca-9,11,13-trienoic acid | | 9-cis,11-trans,13-cis- | octadecatrienoic acid | | | punicinic acid | | | trichosanic acid | | | trichosanoic acid |
Articles:
| PubMed: | Bioactivity and biotechnological production of punicic acid. |
| PubMed: | Quality of pomegranate pomace as affected by drying method. |
| PubMed: | Insulin resistance in 3T3-L1 adipocytes by TNF-α is improved by punicic acid through upregulation of insulin signalling pathway and endocrine function, and downregulation of proinflammatory cytokines. |
| PubMed: | Stimulation of liver IGF-1 expression promotes peak bone mass achievement in growing rats: a study with pomegranate seed oil. |
| PubMed: | Metabolic engineering of Schizosaccharomyces pombe to produce punicic acid, a conjugated fatty acid with nutraceutic properties. |
| PubMed: | Phytochemical content, Fatty acids composition and antioxidant potential of different pomegranate parts: Comparison between edible and non edible varieties grown in Tunisia. |
| PubMed: | Optimisation of Microwave-Assisted Extraction of Pomegranate (Punica granatumL.) Seed Oil and Evaluation
of Its Physicochemical and Bioactive Properties. |
| PubMed: | Pomegranate seed oil influences the fatty acids profile and reduces the activity of desaturases in livers of Sprague-Dawley rats. |
| PubMed: | Punicic acid: A striking health substance to combat metabolic syndromes in humans. |
| PubMed: | Pomegranate as a possible treatment in reducing risk of developing wound healing, obesity, neurodegenerative disorders, and diabetes mellitus. |
| PubMed: | The linin promoter is highly effective in enhancing punicic acid production in Arabidopsis. |
| PubMed: | Effect of dietary pomegranate seed oil on laying hen performance and physicochemical properties of eggs. |
| PubMed: | Oxidative Stability of Pomegranate (Punica granatum L.) Seed Oil to Simulated Gastric Conditions and Thermal Stress. |
| PubMed: | Influence of pomegranate seed oil and bitter melon aqueous extract on polyunsaturated fatty acids and their lipoxygenase metabolites concentration in serum of rats. |
| PubMed: | The Effect of Xanthigen on the Expression of Brown Adipose Tissue Assessed by ¹⁸F-FDG PET. |
| PubMed: | Incorporation and effects of punicic acid on muscle and adipose tissues of rats. |
| PubMed: | Modeling-Enabled Characterization of Novel NLRX1 Ligands. |
| PubMed: | Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant. |
| PubMed: | New lipase assay using Pomegranate oil coating in microtiter plates. |
| PubMed: | Insulin resistance by TNF-α is associated with mitochondrial dysfunction in 3T3-L1 adipocytes and is ameliorated by punicic acid, a PPARγ agonist. |
| PubMed: | Modulation of peroxisome proliferator-activated receptor gamma (PPAR γ) by conjugated fatty acid in obesity and inflammatory bowel disease. |
| PubMed: | Pomegranate and its components as alternative treatment for prostate cancer. |
| PubMed: | Punica granatum cv. Dente di Cavallo seed ethanolic extract: antioxidant and antiproliferative activities. |
| PubMed: | An in vitro study reveals the nutraceutical potential of punicic acid relevant to diabetes via enhanced GLUT4 expression and adiponectin secretion. |
| PubMed: | Luteolin, ellagic acid and punicic acid are natural products that inhibit prostate cancer metastasis. |
| PubMed: | Combined transgenic expression of Punica granatum conjugase (FADX) and FAD2 desaturase in high linoleic acid Arabidopsis thaliana mutant leads to increased accumulation of punicic acid. |
| PubMed: | Potential anti-inflammatory effects of the hydrophilic fraction of pomegranate (Punica granatum L.) seed oil on breast cancer cell lines. |
| PubMed: | Conjugated linolenic acids and their bioactivities: a review. |
| PubMed: | Pomegranate seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: the case of genetic CJD. |
| PubMed: | Effects of pomegranate seed oil on insulin release in rats with type 2 diabetes. |
| PubMed: | Pomegranate Seed Oil Modulates Functions and Survival of BV-2 Microglial Cells in vitro. |
| PubMed: | Enrichment of functional properties of ice cream with pomegranate by-products. |
| PubMed: | Pomegranate seed oil prevents bone loss in a mice model of osteoporosis, through osteoblastic stimulation, osteoclastic inhibition and decreased inflammatory status. |
| PubMed: | Preventive and prophylactic mechanisms of action of pomegranate bioactive constituents. |
| PubMed: | Pomegranate and type 2 diabetes. |
| PubMed: | Effects of pomegranate seed oil on glucose and lipid metabolism-related organs in rats fed an obesogenic diet. |
| PubMed: | Long chain fatty acids and gene expression in inflammation and immunity. |
| PubMed: | Nutritional protective mechanisms against gut inflammation. |
| PubMed: | Jacaric acid and its octadecatrienoic acid geoisomers induce apoptosis selectively in cancerous human prostate cells: a mechanistic and 3-D structure-activity study. |
| PubMed: | Protective effect of conjugated linolenic acid isomers present in vegetable oils against arsenite-induced renal toxicity in rat model. |
| PubMed: | Specific pomegranate juice components as potential inhibitors of prostate cancer metastasis. |
| PubMed: | Pomegranate juice and specific components inhibit cell and molecular processes critical for metastasis of breast cancer. |
| PubMed: | Synergistic effect of conjugated linolenic acid isomers against induced oxidative stress, inflammation and erythrocyte membrane disintegrity in rat model. |
| PubMed: | Optimization of ultrasonic-assisted extraction of pomegranate (Punica granatum L.) seed oil. |
| PubMed: | Pomegranate seed oil reduces intestinal damage in a rat model of necrotizing enterocolitis. |
| PubMed: | Antioxidant properties and phytochemical composition of China-grown pomegranate seeds. |
| PubMed: | Uptake of conjugated linolenic acids and conversion to cis-9, trans-11-or trans-9, trans-11-conjugated linoleic acids in Caco-2 cells. |
| PubMed: | Conjugated fatty acid synthesis: residues 111 and 115 influence product partitioning of Momordica charantia conjugase. |
| PubMed: | Xanthigen suppresses preadipocyte differentiation and adipogenesis through down-regulation of PPARγ and C/EBPs and modulation of SIRT-1, AMPK, and FoxO pathways. |
| PubMed: | Antioxidant and anti-inflammatory effect of conjugated linolenic acid isomers against streptozotocin-induced diabetes. |
| PubMed: | Effect of pomegranate seed oil on serum TNF-α level in dyslipidemic patients. |
| PubMed: | Comparative study of hypocholesterolemic and hypolipidemic effects of conjugated linolenic acid isomers against induced biochemical perturbations and aberration in erythrocyte membrane fluidity. |
| PubMed: | Short communication: effects of supplementation with pomegranate seed pulp on concentrations of conjugated linoleic acid and punicic acid in goat milk. |
| PubMed: | Activation of PPARγ and δ by dietary punicic acid ameliorates intestinal inflammation in mice. |
| PubMed: | Pomegranate seed oil, a rich source of punicic acid, prevents diet-induced obesity and insulin resistance in mice. |
| PubMed: | Antioxidant effect of vegetable oils containing conjugated linolenic acid isomers against induced tissue lipid peroxidation and inflammation in rat model. |
| PubMed: | Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PPAR Agonists. |
| PubMed: | Recent advances in the analysis of the site-specific isotopic fractionation of metabolites such as fatty acids using anisotropic natural-abundance 2H NMR spectroscopy: application to conjugated linolenic methyl esters. |
| PubMed: | Growth inhibitory, antiandrogenic, and pro-apoptotic effects of punicic acid in LNCaP human prostate cancer cells. |
| PubMed: | Ameliorative role of conjugated linolenic acid isomers against oxidative DNA damage induced by sodium arsenite in rat model. |
| PubMed: | Effect of pomegranate seed oil on hyperlipidaemic subjects: a double-blind placebo-controlled clinical trial. |
| PubMed: | Pomegranate (Punica granatum) seed linolenic acid isomers: concentration-dependent modulation of estrogen receptor activity. |
| PubMed: | Punicic acid is an omega-5 fatty acid capable of inhibiting breast cancer proliferation. |
| PubMed: | Activation of PPAR gamma and alpha by punicic acid ameliorates glucose tolerance and suppresses obesity-related inflammation. |
| PubMed: | Incorporation and metabolism of punicic acid in healthy young humans. |
| PubMed: | Antioxidant capacity and lipid characterization of six Georgia-grown pomegranate cultivars. |
| PubMed: | Punicic acid a conjugated linolenic acid inhibits TNFalpha-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats. |
| PubMed: | Comparative study of antioxidant activity of alpha-eleostearic acid and punicic acid against oxidative stress generated by sodium arsenite. |
| PubMed: | Punicic acid from Trichosanthes kirilowii seed oil is rapidly metabolized to conjugated linoleic acid in rats. |
| PubMed: | Pomegranate oil analysis with emphasis on MALDI-TOF/MS triacylglycerol fingerprinting. |
| PubMed: | Genetically modified rapeseed oil containing cis-9,trans-11,cis-13-octadecatrienoic acid affects body fat mass and lipid metabolism in mice. |
| PubMed: | Re-characterization of three conjugated linolenic acid isomers by GC-MS and NMR. |
| PubMed: | Conjugated linolenic acid is slowly absorbed in rat intestine, but quickly converted to conjugated linoleic acid. |
| PubMed: | Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice. |
| PubMed: | Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel. |
| PubMed: | Dietary effect of pomegranate seed oil rich in 9cis, 11trans, 13cis conjugated linolenic acid on lipid metabolism in obese, hyperlipidemic OLETF rats. |
| PubMed: | Delta 12-oleate desaturase-related enzymes associated with formation of conjugated trans-delta 11, cis-delta 13 double bonds. |
| PubMed: | Formation of conjugated Delta11Delta13-double bonds by Delta12-linoleic acid (1,4)-acyl-lipid-desaturase in pomegranate seeds. |
| PubMed: | Antioxidant and eicosanoid enzyme inhibition properties of pomegranate seed oil and fermented juice flavonoids. |
|