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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.002704 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for artocarpin usage levels up to: | | | not for fragrance use.
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| Recommendation for artocarpin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5458461 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | 2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-[(E)-3-methylbut-1-enyl]-3-(3-methylbut-2-enyl)chromen-4-one |
References:
| | 2-(2,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-6-[(E)-3-methylbut-1-enyl]-3-(3-methylbut-2-enyl)chromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5458461 |
| Pubchem (cas): | 7608-44-8 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2-(2,4- | dihydroxyphenyl)-5-hydroxy-7-methoxy-6-[(E)-3-methylbut-1-enyl]-3-(3-methylbut-2-enyl)chromen-4-one |
Articles:
| PubMed: | Identification of cytochrome P450 isoforms involved in the metabolism of artocarpin and assessment of its drug-drug interaction. |
| PubMed: | The effects of artocarpin on wound healing: in vitro and in vivo studies. |
| PubMed: | Artocarpin-enriched (Artocarpus altilis) Heartwood Extract Provides Protection Against UVB-induced Mechanical Damage in Dermal Fibroblasts. |
| PubMed: | Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells. |
| PubMed: | Chemoprevention of Colorectal Cancer by Artocarpin, a Dietary Phytochemical from Artocarpus heterophyllus. |
| PubMed: | Flavonoids from the leaves and heartwoods of Artocarpus lowii King and their bioactivities. |
| PubMed: | Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. |
| PubMed: | Moraceae Plants with Tyrosinase Inhibitory Activity: A Review. |
| PubMed: | Enhanced autophagic activity of artocarpin in human hepatocellular carcinoma cells through improving its solubility by a nanoparticle system. |
| PubMed: | Dual Acting Neuraminidase Inhibitors Open New Opportunities to Disrupt the Lethal Synergism between Streptococcus pneumoniae and Influenza Virus. |
| PubMed: | Synergistic effect of artocarpin on antibacterial activity of some antibiotics against methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. |
| PubMed: | Artocarpus altilis heartwood extract protects skin against UVB in vitro and in vivo. |
| PubMed: | Flavonoids from Artocarpus anisophyllus and their bioactivities. |
| PubMed: | Antibacterial assay-guided isolation of active compounds from Artocarpus heterophyllus heartwoods. |
| PubMed: | Artocarpin Induces Apoptosis in Human Cutaneous Squamous Cell Carcinoma HSC-1 Cells and Its Cytotoxic Activity Is Dependent on Protein-Nutrient Concentration. |
| PubMed: | Antipneumococcal activity of neuraminidase inhibiting artocarpin. |
| PubMed: | Antihepatoma activity of Artocarpus communis is higher in fractions with high artocarpin content. |
| PubMed: | Artocarpin attenuates ultraviolet B-induced skin damage in hairless mice by antioxidant and anti-inflammatory effect. |
| PubMed: | Antityrosinase and antimicrobial activities from Thai medicinal plants. |
| PubMed: | Elucidation of carbohydrate molecular interaction mechanism of recombinant and native ArtinM. |
| PubMed: | Prenylated flavonoids from Artocarpus altilis: antioxidant activities and inhibitory effects on melanin production. |
| PubMed: | [Flavonoids from Artocarpus hypargyreus]. |
| PubMed: | Quaternary association in beta-prism I2 fold plant lectins: insights from X-ray crystallography, modelling and molecular dynamics. |
| PubMed: | Artocarpus plants as a potential source of skin whitening agents. |
| PubMed: | Novel neuraminidase inhibitors: identification, biological evaluation and investigations of the binding mode. |
| PubMed: | Depigmenting action of a nanoemulsion containing heartwood extract of Artocarpus incisus on UVB-induced hyperpigmentation in C57BL/6 mice. |
| PubMed: | Cytotoxic effect of artocarpin on T47D cells. |
| PubMed: | Prenylated flavones from Artocarpus altilis. |
| PubMed: | In vitro protection of umbilical cord blood-derived primitive hematopoietic stem progenitor cell pool by mannose-specific lectins via antioxidant mechanisms. |
| PubMed: | [Effects of cycloartocarpin A and artocarpin extracted from Fructus Artocarpin Heterophylli on apoptosis of SMMC-7721 and SGC-7901 cells]. |
| PubMed: | Isoprenoid-substituted flavonoids from wood of Artocarpus heterophyllus on B16 melanoma cells: cytotoxicity and structural criteria. |
| PubMed: | A simple micro-method for determining precise oligosaccharidic specificity of mannose-binding lectins. |
| PubMed: | Neutrophil activation induced by ArtinM: release of inflammatory mediators and enhancement of effector functions. |
| PubMed: | Two structurally identical mannose-specific jacalin-related lectins display different effects on human T lymphocyte activation and cell death. |
| PubMed: | The lectin KM+ induces corneal epithelial wound healing in rabbits. |
| PubMed: | An oxepinoflavone from Artocarpus elasticus with cytotoxic activity against P-388 cells. |
| PubMed: | Isolation of tyrosinase inhibitors from Artocarpus heterophyllus and use of its extract as antibrowning agent. |
| PubMed: | Artin M: a rational substitution for the names artocarpin and KM+. |
| PubMed: | Evaluation of the effect of Thai breadfruit's heartwood extract on melanogenesis-inhibitory and antioxidation activities. |
| PubMed: | Analysis of the sugar-binding specificity of mannose-binding-type Jacalin-related lectins by frontal affinity chromatography--an approach to functional classification. |
| PubMed: | Targeted transfollicular delivery of artocarpin extract from Artocarpus incisus by means of microparticles. |
| PubMed: | Antiherpetic flavones from the heartwood of Artocarpus gomezianus. |
| PubMed: | Inhibitory effect of isoprenoid-substituted flavonoids isolated from Artocarpus heterophyllus on melanin biosynthesis. |
| PubMed: | Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production. |
| PubMed: | Neutrophil activation induced by the lectin KM+ involves binding to CXCR2. |
| PubMed: | Lectin KM+-induced neutrophil haptotaxis involves binding to laminin. |
| PubMed: | Free radicals scavenging efficiency of a few naturally occurring flavonoids: a comparative study. |
| PubMed: | Artocarpin is a polyspecific jacalin-related lectin with a monosaccharide preference for mannose. |
| PubMed: | New isoprenylated flavones, artochamins A--E, and cytotoxic principles from Artocarpus chama. |
| PubMed: | Structural basis for the carbohydrate specificities of artocarpin: variation in the length of a loop as a strategy for generating ligand specificity. |
| PubMed: | Crystal structures of artocarpin, a Moraceae lectin with mannose specificity, and its complex with methyl-alpha-D-mannose: implications to the generation of carbohydrate specificity. |
| PubMed: | The skin-lightening effects of artocarpin on UVB-induced pigmentation. |
| PubMed: | Isothermal titration calorimetric studies on the binding of deoxytrimannoside derivatives with artocarpin: implications for a deep-seated combining site in lectins |
| PubMed: | Isothermal titration calorimetric studies on the binding of deoxytrimannoside derivatives with artocarpin: implications for a deep-seated combining site in lectins. |
| PubMed: | Tyrosinase inhibitors from Artocarpus gomezianus. |
| PubMed: | The 5 alpha-reductase inhibitory components from heartwood of Artocarpus incisus: structure-activity investigations. |
| PubMed: | Thermodynamic studies of saccharide binding to artocarpin, a B-cell mitogen, reveals the extended nature of its interaction with mannotriose [3,6-Di-O-(alpha-D-mannopyranosyl)-D-mannose]. |
| PubMed: | A new prenylated flavone from Artocarpus champeden inhibits the K(+)-dependent amino acid transport in Bombyx mori midgut. |
| PubMed: | Homology between jacalin and artocarpin from jackfruit (Artocarpus integrifolia) seeds. Partial sequence and preliminary crystallographic studies of artocarpin. |
| PubMed: | Differential binding properties of Gal/GalNAc specific lectins available for characterization of glycoreceptors. |
| PubMed: | Carbohydrate binding specificity of the B-cell maturation mitogen from Artocarpus integrifolia seeds. |
| PubMed: | Artocarpin-galactomannan interaction: characterization of combining site of artocarpin. |
| PubMed: | Jacalin and artocarpin. |
| PubMed: | Activation of T and B cells by a crude extract of Artocarpus integrifolia is mediated by a lectin distinct from jacalin. |
| PubMed: | Chemical modification studies of Artocarpus lakoocha lectin artocarpin. |
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