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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 0.001658 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Grifolin 98%
Odor: characteristic Use: Grifolin is a natural compound isolated from the fresh fruiting bodies of Alba |
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for grifolin usage levels up to: | | | not for fragrance use.
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| Recommendation for grifolin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5372312 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | 5-methyl-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]benzene-1,3-diol |
References:
| | 5-methyl-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]benzene-1,3-diol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5372312 |
| Pubchem (cas): | 6903-07-7 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2- | farnesyl-5-methylresorcinol | | 5- | methyl-2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]benzene-1,3-diol |
Articles:
| PubMed: | Grifolin Attenuates White Matter Lesion in Oxygen/Glucose Deprivation. |
| PubMed: | Grifolin induces apoptosis and promotes cell cycle arrest in the A2780 human ovarian cancer cell line via inactivation of the ERK1/2 and Akt pathways. |
| PubMed: | Grifolin exhibits anti-cancer activity by inhibiting the development and invasion of gastric tumor cells. |
| PubMed: | Grifolin derivatives from Albatrellus ovinus as TRPV1 receptor blockers for cosmetic applications. |
| PubMed: | Total Synthesis of Grifolin, Grifolic Acid, LL-Z1272α, LL-Z1272β, and Ilicicolinic Acid A. |
| PubMed: | Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1α and Fra-1 / LSF- MMP2 / CD44 axes. |
| PubMed: | Grifolin induces autophagic cell death by inhibiting the Akt/mTOR/S6K pathway in human ovarian cancer cells. |
| PubMed: | Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis. |
| PubMed: | The role of targeting kinase activity by natural products in cancer chemoprevention and chemotherapy (Review). |
| PubMed: | Nine new farnesylphenols from the basidiomycete albatrellus caeruleoporus. |
| PubMed: | A review on antifungal activity of mushroom (basidiomycetes) extracts and isolated compounds. |
| PubMed: | Meroterpenoid pigments from the basidiomycete Albatrellus ovinus. |
| PubMed: | DAPK1 mediates the G1 phase arrest in human nasopharyngeal carcinoma cells induced by grifolin, a potential antitumor natural product. |
| PubMed: | Grifolin, a potent antitumour natural product upregulates death-associated protein kinase 1 DAPK1 via p53 in nasopharyngeal carcinoma cells. |
| PubMed: | Cyathane diterpenoids and nitrogenous terphenyl derivative from the fruiting bodies of basidiomycete Phellodon niger. |
| PubMed: | Cytotoxic grifolin derivatives isolated from the wild mushroom Boletus pseudocalopus (Basidiomycetes). |
| PubMed: | Antibacterial compounds from mushrooms I: a lanostane-type triterpene and prenylphenol derivatives from Jahnoporus hirtus and Albatrellus flettii and their activities against Bacillus cereus and Enterococcus faecalis. |
| PubMed: | Novel selective ligands for free fatty acid receptors GPR120 and GPR40. |
| PubMed: | A new meroterpenoid pigment from the basidiomycete Albatrellus confluens. |
| PubMed: | Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, induces cell-cycle arrest in G1 phase via the ERK1/2 pathway. |
| PubMed: | Grifolin induces apoptosis via inhibition of PI3K/AKT signalling pathway in human osteosarcoma cells. |
| PubMed: | Screening of novel nuclear receptor agonists by a convenient reporter gene assay system using green fluorescent protein derivatives. |
| PubMed: | Grifolin derivatives from Albatrellus caeruleoporus, new inhibitors of nitric oxide production in RAW 264.7 cells. |
| PubMed: | Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens, inhibits tumor cell growth by inducing apoptosis in vitro. |
| PubMed: | Activity in vitro and in vivo against plant pathogenic fungi of grifolin isolated from the basidiomycete Albatrellus dispansus. |
| PubMed: | Use of a modified microplate bioassay method to investigate antibacterial activity in the Peruvian medicinal plant Peperomia galioides. |
| PubMed: | Structures and histamine release inhibitory effects of prenylated orcinol derivatives from Rhododendron dauricum. |
| PubMed: | Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product, confluentin. |
| PubMed: | Neogrifolin derivatives possessing anti-oxidative activity from the mushroom Albatrellus ovinus. |
| PubMed: | Antitumor beta glucan from the cultured fruit body of Agaricus blazei. |
| PubMed: | In vitro and in vivo leishmanicidal studies of Peperomia galioides (Piperaceae). |
| PubMed: | Piperogalin, a new prenylated diphenol from Peperomia galioides. |
| PubMed: | Hypocholesterolemic Action of Dietary Grifolin on Rats Fed with a High-cholesterol Diet. |
| PubMed: | Isolation of plasma cholesterol-lowering components from ningyotake (Polyporus confluens) mushroom. |
| PubMed: | A total synthesis of grifolin. |
| PubMed: | Synthesis of grifolin, an antibiotic from a Basidiomycete. |
| PubMed: | The structure of grifolin, an antibiotic from a basidiomycete. |
| PubMed: | Grifolin, an antibiotic from a basidiomycete. |
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