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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 4.207 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for (-)-aspidospermine usage levels up to: | | | not for fragrance use.
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| Recommendation for (-)-aspidospermine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | aspidospermidine, 1-acetyl-17-methoxy- (8CI,9CI) |
Articles:
| PubMed: | Divergent Asymmetric Total Synthesis of (+)-Vincadifformine, (-)-Quebrachamine, (+)-Aspidospermidine, (-)-Aspidospermine, (-)-Pyrifolidine, and Related Natural Products. |
| PubMed: | Identification of an aspidospermine derivative from borage extract as an anti-amyloid compound: A possible link between protein aggregation and antimalarial drugs. |
| PubMed: | Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications. |
| PubMed: | Cytotoxicity, genotoxicity and mechanism of action (via gene expression analysis) of the indole alkaloid aspidospermine (antiparasitic) extracted from Aspidosperma polyneuron in HepG2 cells. |
| PubMed: | Cytotoxic eburnamine-aspidospermine type bisindole alkaloids from Bousigonia mekongensis. |
| PubMed: | Catalytic enantioselective and divergent total synthesis of (+)-10-oxocylindrocarpidine, (+)-cylindrocarpidine, (-)-N-acetylcylindrocarpinol, and (+)-aspidospermine. |
| PubMed: | Angustifonines A and B, cytotoxic bisindole alkaloids from Bousigonia angustifolia. |
| PubMed: | Divergent total syntheses of (-)-aspidospermine and (+)-spegazzinine. |
| PubMed: | Stereoselective formation of fused tricyclic amines from acyclic aldehydes by a cascade process involving condensation, cyclization, and dipolar cycloaddition. |
| PubMed: | The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors. |
| PubMed: | Efficient synthetic approaches to the common scaffold of indole alkaloids. |
| PubMed: | Highly efficient synthesis of tricyclic amines by a cyclization/cycloaddition cascade: total syntheses of aspidospermine, aspidospermidine, and quebrachamine. |
| PubMed: | Formal synthesis of aspidosperma alkaloids via the intramolecular [3 + 2] cycloaddition of 2-azapentdienyllithiums. |
| PubMed: | Revisiting a classic approach to the Aspidosperma alkaloids: an intramolecular Schmidt reaction mediated synthesis of (+)-aspidospermidine. |
| PubMed: | Total synthesis of (-)-aspidospermine via diastereoselective ring-closing olefin metathesis. |
| PubMed: | Synthesis of vinca alkaloids and related compounds. 100. Stereoselective oxidation reactions of compounds with the aspidospermane and quebrachamine ring system. First synthesis of some alkaloids containing the epoxy ring. |
| PubMed: | Antiplasmodial activity of aspidosperma indole alkaloids. |
| PubMed: | Alkaloids from Aspidosperma species from Bolivia. |
| PubMed: | Alkaloids from leaves and stems of Vallesia glabra. |
| PubMed: | Isolation and biological activity of aspidospermine and quebrachamine from an Aspidosperma tree source. |
| PubMed: | New compounds with cytotoxic and antitumor effects. Part 6: Monomeric indole alkaloids of vinca minor L. and their effect on P388 cells. |
| PubMed: | Alkaloids from Roots of Strempeliopsis strempelioides - Structures of Strempeliopine and Strempeliopidine1. |
| PubMed: | Microbial transformation of aspidospermine. |
| PubMed: | Biological and phytochemical evaluation of plants. XI. Isolation of aspidospermine, quebrachidine, rhazinilam, (-)-pyrifolidine, and akuammidine from Aspidosperma quebracho-blanco (Apocynaceae). |
| PubMed: | The synthesis of a racemic stereoisomer of aspidospermine. |
| PubMed: | The stereochemistry of intermediates in the total synthesis of dl-aspidospermine. |
| PubMed: | The absolute configuration of (-)-aspidospermine. |
| PubMed: | Total synthesis of aspidospermine. |
| PubMed: | [Determination of the absolute configuration of alkaloids of the aspidospermine group by means of optical comparison with alkaloids of the strychnine group]. |
| PubMed: | A note on the pharmacology of aspidospermine. |
| PubMed: | The constitution of aspidospermine. |
| PubMed: | Aspidospermine. |
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