|
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 1e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for nebularine usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for nebularine flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
| | (2R,3S,4R,5R)-2-(hydroxymethyl)-5-purin-9-yloxolane-3,4-diol |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 68368 |
| Pubchem (cas): | 550-33-4 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| (2R,3S,4R,5R)-2-( | hydroxymethyl)-5-purin-9-yloxolane-3,4-diol | | | purine ribonucleoside | | 9H- | purine, 9-beta-D-ribofuranosyl- | | 9-(beta-D- | ribofuranosyl)purine | | | ribosylpurine |
Articles:
| PubMed: | Effect of nucleobase change on cytosine deamination through DNA photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside. |
| PubMed: | Versatile synthesis and biological evaluation of novel 3'-fluorinated purine nucleosides. |
| PubMed: | C2-substituted aromatic cytokinin sugar conjugates delay the onset of senescence by maintaining the activity of the photosynthetic apparatus. |
| PubMed: | A novel nucleoside from the edible mushroom, Tricholoma japonicum. |
| PubMed: | Synthesis of new nebularine analogues and their inhibitory activity against adenosine deaminase. |
| PubMed: | Diacarperoxide S, new norterpene cyclic peroxide from the sponge Diacarnus megaspinorhabdosa. |
| PubMed: | Synthesis and evaluation of the substrate activity of C-6 substituted purine ribosides with E. coli purine nucleoside phosphorylase: palladium mediated cross-coupling of organozinc halides with 6-chloropurine nucleosides. |
| PubMed: | Coumarin-purine ribofuranoside conjugates as new agents against hepatitis C virus. |
| PubMed: | Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors. |
| PubMed: | Isolation and biochemical characterization of delta-aminolevulinic acid dehydratase from Streptomyces yokosukanensis ATCC 25520. |
| PubMed: | Modulation of AMP deaminase in rat hearts subjected to ischemia and reperfusion by purine riboside. |
| PubMed: | Chemical Constituents of the Fruiting Bodies of Clitocybe nebularis and Their Antifungal Activity. |
| PubMed: | Characterization of the metallocenter of rabbit skeletal muscle AMP deaminase. A new model for substrate interactions at a dinuclear cocatalytic Zn site. |
| PubMed: | Structures, biogenesis, and biological activities of pyrano[4,3-c]isochromen-4-one derivatives from the Fungus Phellinus igniarius. |
| PubMed: | Cytokinins inhibit epiphyllous plantlet development on leaves of Bryophyllum (Kalanchoƫ) marnierianum. |
| PubMed: | Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA. |
| PubMed: | Binding of MutS mismatch repair protein to DNA containing UV photoproducts, "mismatched" opposite Watson--Crick and novel nucleotides, in different DNA sequence contexts. |
| PubMed: | Electrochemical detection of lesions in DNA. |
| PubMed: | Human UP1 as a model for understanding purine recognition in the family of proteins containing the RNA recognition motif (RRM). |
| PubMed: | The assignment of downfield proton resonances in an enzyme inhibitor complex using time-dependent saturation transferred NOEs. |
| PubMed: | The NMR studies of substituent effects on the N-H...N hydrogen bond in duplex DNA using 2'-deoxynebularine and 15N labeled 5-substituted-2'-deoxyuridine base pairs. |
| PubMed: | Substrate analogues for an RNA-editing adenosine deaminase: mechanistic investigation and inhibitor design. |
| PubMed: | Involvement of gibberellin and cytokinin in the formation of embryogenic cell clumps in carrot (Daucus carota). |
| PubMed: | [Purine nucleoside phosphorylase (PNP)]. |
| PubMed: | Amino acid- and purine ribonucleoside-induced germination of Bacillus anthracis DeltaSterne endospores: gerS mediates responses to aromatic ring structures. |
| PubMed: | The cytotoxic effect of purine riboside on COS-7 cells. |
| PubMed: | Recognition of GT mismatches by Vsr mismatch endonuclease. |
| PubMed: | Crystallization and preliminary analysis of bovine adenosine deaminase. |
| PubMed: | Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds. |
| PubMed: | The design and synthesis of inhibitors of adenosine 5'-monophosphate deaminase. |
| PubMed: | ATP depletion, purine riboside triphosphate accumulation and rat thymocyte death induced by purine riboside. |
| PubMed: | Characterization of hydrogen bonding in the complex of adenosine deaminase with a transition state analogue: a Raman spectroscopic study. |
| PubMed: | Nebularine (9-2'-deoxy-beta-D-ribofuranosylpurine) has the template characteristics of adenine in vivo and in vitro. |
| PubMed: | Synthesis, antiproliferative and antiviral activity of imidazo[4,5-d]isothiazole nucleosides as 5:5 fused analogs of nebularine and 6-methylpurine ribonucleoside. |
| PubMed: | Synthesis and evaluation of 6-(dibromomethyl)-5-nitropyrimidines as potential antitumor agents. |
| PubMed: | Site-directed mutagenesis of active site glutamate-217 in mouse adenosine deaminase. |
| PubMed: | DNA determinants and substrate specificities of Escherichia coli MutY. |
| PubMed: | Net uptake of orthophosphate in Ehrlich ascites tumor cells in the presence of purine riboside may be rate limiting for the expansion of the pool of ribonucleotides. |
| PubMed: | Importance of specific guanosine N7-nitrogens and purine amino groups for efficient cleavage by a hammerhead ribozyme. |
| PubMed: | Hypersensitivity of an enzyme reaction to solvent water. |
| PubMed: | S-adenosylhomocysteine hydrolase from Acinetobacter calcoaceticus: purification and partial characterization. |
| PubMed: | Inhibition of adenosine deaminase by azapurine ribonucleosides. |
| PubMed: | A transition state in pieces: major contributions of entropic effects to ligand binding by adenosine deaminase. |
| PubMed: | New hypoxanthine nucleosides with RNA antiviral activity. |
| PubMed: | The role of the exocyclic amino groups of conserved purines in hammerhead ribozyme cleavage. |
| PubMed: | The rate of formation of transition-state analogues in the active site of adenosine deaminase is encounter-controlled: implications for the mechanism. |
| PubMed: | Kinetic properties of the common electrophoretic variants of human S-adenosylhomocysteine hydrolase (AHCY): the effect of four nucleoside analogue inhibitors. |
| PubMed: | Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues. |
| PubMed: | Inhibition of axenically grown Entamoeba histolytica by purine nucleoside analogs and actions of natural nucleosides. |
| PubMed: | Structure-activity relationship of ligands of human plasma adenosine deaminase2. |
| PubMed: | Preparative purification of adenosine deaminase from human erythrocytes by affinity chromatography. |
| PubMed: | Synthesis, antiproliferative, and antiviral activity of certain 4-substituted and 4,5-disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines. |
| PubMed: | Enzymatic synthesis of purine 2'-deoxyriboside and its properties as an inhibitor of adenosine deaminases from calf intestinal mucosa and Bacillus cereus. |
| PubMed: | Contribution of a single hydroxyl group to transition-state discrimination by adenosine deaminase: evidence for an "entropy trap" mechanism. |
| PubMed: | Major enhancement of the affinity of an enzyme for a transition-state analog by a single hydroxyl group. |
| PubMed: | Transition-state stabilization by adenosine deaminase: 1,6-addition of water to purine ribonucleoside, the enzyme's affinity for 6-hydroxy-1,6-dihydropurine ribonucleoside, and the effective concentration of substrate water at the active site. |
| PubMed: | Antiviral activities and the mechanism of 9-beta-D-ribofuranosyl-6-alkylthiopurines on several RNA viruses from animals. |
| PubMed: | Selective killing of glucose-deprived hypoxic cells by hyperthermia. I. Protection by purine ribonucleosides. |
| PubMed: | Treatment of schistosomiasis by purine nucleoside analogues in combination with nucleoside transport inhibitors. |
| PubMed: | Metabolism of adenosine analogues by Schistosoma mansoni and the effect of nucleoside transport inhibitors. |
| PubMed: | Affinity difference of adenosine deaminases for the purine riboside-epoxyactivated Sepharose 6B column. |
| PubMed: | Guanine and adenine analogues as tools in the investigation of the mechanisms of mismatch repair in E. coli. |
| PubMed: | Oligonucleotide duplexes containing inosine, 7-deazainosine, tubercidin, nebularine and 7-deazanebularine as substrates for restriction endonucleases HindII, SalI and TaqI. |
| PubMed: | Germination of Bacillus cereus spores induced by purine ribosides and their analogs: effects of modification of base and sugar moieties of purine nucleosides on germination-inducing activity. |
| PubMed: | [Protection of cells by nucleoside transport inhibitor combined with nebularine and the therapeutic effect on transplantable mouse tumors]. |
| PubMed: | Occurrence of S-adenosylhomocysteine hydrolase in prokaryote cells. Characterization of the enzyme from Alcaligenes faecalis and role of the enzyme in the activated methyl cycle. |
| PubMed: | Fast atom bombardment combined with tandem mass spectrometry for the determination of nucleosides. |
| PubMed: | Adenosine deaminase: solvent isotope and pH effects on the binding of transition-state and ground-state analogue inhibitors. |
| PubMed: | alpha-Oxyalkylation and alpha-amidoalkylation of nebularine tri-O-benzoate via homolytic processes. |
| PubMed: | Dextran-linked purine nucleosides as substrates and inhibitors of adenosine deaminase. |
| PubMed: | Purine catabolism in plants : purification and some properties of inosine nucleosidase from yellow lupin (lupinus luteus L.) seeds. |
| PubMed: | Circular dichroism changes in adenosine deaminase upon substrate analog binding. |
| PubMed: | Synthesis of 6- and 8-alkynylated purines and their ribonucleosides by the coupling of halopurines with alkynes. |
| PubMed: | Treatment of mouse neoplasms with high doses of tubercidin. |
| PubMed: | Therapy of mouse leukemia L1210 with combinations of nebularine and nitrobenzylthioinosine 5'-monophosphate. |
| PubMed: | Adenosine analogues as substrates and inhibitors of S-adenosylhomocysteine hydrolase. |
| PubMed: | Protection of mice against lethal dosages of nebularine by nitrobenzylthioinosine, an inhibitor of nucleoside transport. |
| PubMed: | Cryptofluorescent analogs of cobalamin coenzymes: synthesis and characterization. |
| PubMed: | Effects of purine riboside on nucleic acid synthesis in ascites cells. |
| PubMed: | Conformations of the nucleoside analogs formycin, 2-azaadenosine, and nebularine in solution. |
| PubMed: | Substrate specificity of ribosomal peptidyltransferase. Effect of modification in the heterocyclic, carbohydrate and amino acid moiety of 2'(3')-O-L-phenylalanyladenosine. |
| PubMed: | Improved methods for the study of drug effects on purine metabolism and their application to nebularine and 7-deazanebularine. |
| PubMed: | Synthesis in nucleoside antibiotics. II. Facile synthesis of nebularine and its analogs by a modified fusion procedure. |
| PubMed: | A new synthesis of nebularine and 7-D-ribofuranosylpurine (synthesis in nucleoside antibiotics. I. |
| PubMed: | PURINE NUCLEOSIDES. IX. THE SYNTHESIS OF 9-BETA-D-RIBOFURANOSYL URIC ACID AND OTHER RELATED 8-SUBSTITUTED PURINE RIBONUCLEOSIDES. |
| PubMed: | STUDIES ON SYNTHETIC NUCLEOSIDES. IV. A NEW SYNTHETIC METHOD OF PYRIMIDINE AND PURINE RIBOSIDES. |
| PubMed: | A POSSIBLE MECHANISM OF THE TRANSFORMATION OF PURINE RIBONUCLEOSIDE TO DEOXYRIBONUCLEOSIDE. |
| PubMed: | Purine ribonucleoside and deoxyribonucleoside phosphorylase in human erythrocytes. |
| PubMed: | Characterization of a new purine riboside isolated from Fusarium species. |
| PubMed: | A study of the metabolism of purine riboside. |
| PubMed: | The relationship between the cleavage of purine ribosides by bacterial spores and the germination of the spores. |
| PubMed: | The synthesis of 9-beta-D-ribofuranosylpurine and the identity of nebularine. |
| PubMed: | Utilization of some purine riboside derivatives by Lactobacillus casei. |
| PubMed: | [Phosphorolysis and hydrolysis of purine ribosides by enzymes from yeast]. |
| PubMed: | The enzymatic synthesis of purine ribosides. |
|