withania somnifera leaf/root extract
extract of the leaves and roots of withania somnifera (l.), solanaceae
 
Notes:
None found
Synonyms   Articles   Notes   Search
Name: withania somnifera leaf/root extract
CAS Number: 90147-43-6 
ECHA EC Number: 290-434-9
Category: cosmetic ingredient for skin conditioning
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
PubMed: Search
NCBI: Search
Synonyms   Articles   Notes   Search   Top
Physical Properties:
Food Chemicals Codex Listed: No
Synonyms   Articles   Notes   Search   Top
Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
Synonyms   Articles   Notes   Search   Top
Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
Synonyms   Articles   Notes   Search   Top
Suppliers:
 None found
Synonyms   Articles   Notes   Search   Top
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
Synonyms   Articles   Notes   Search   Top
Safety in Use Information:
Category: cosmetic ingredient for skin conditioning
Recommendation for withania somnifera leaf/root extract usage levels up to:
 not for fragrance use.
 
Recommendation for withania somnifera leaf/root extract flavor usage levels up to:
 not for flavor use.
Synonyms   Articles   Notes   Search   Top
Safety References:
ClinicalTrials.gov: search
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
National Institute of Allergy and Infectious Diseases: Data
 withania somnifera leaf/root extract
Chemidplus: 0090147436
Synonyms   Articles   Notes   Search   Top
References:
 withania somnifera leaf/root extract
Pubchem (cas): 90147-43-6
Synonyms   Articles   Notes   Search   Top
Other Information:
Wikipedia: View
Synonyms   Articles   Notes   Search   Top
Potential Blenders and core components note
 
None Found
 
Synonyms   Articles   Notes   Search   Top
Potential Uses:
None Found
Synonyms   Articles   Notes   Search   Top
Occurrence (nature, food, other): note
 ashwagandha leaf
Search Trop  Picture
Synonyms   Articles   Notes   Search   Top
Synonyms:
 ajagandha leaf/root extract
 ashwagandha leaf/root extract
winter cherry leaf/root extract
 extract of the leaves and roots of withania somnifera (l.), solanaceae
indian ginseng leaf/root extract
Synonyms   Articles   Notes   Search   Top
Articles:
PubMed: Evaluation of Kunapa jala and Pancha gavya on plant quality, physiology, biochemistry, yield and growth attributes - A case study of Withania somnifera Dun.
PubMed: Herbal pre-conditioning induces proliferation and delays senescence in Wharton's Jelly Mesenchymal Stem Cells.
PubMed: Molecular docking, QSAR and ADMET studies of withanolide analogs against breast cancer.
PubMed: Changes in the leaf proteome profile of Withania somnifera (L.) Dunal in response to Alternaria alternata infection.
PubMed: Intermittent fasting combined with supplementation with Ayurvedic herbs reduces anxiety in middle aged female rats by anti-inflammatory pathways.
PubMed: Comprehensive assessment of the genes involved in withanolide biosynthesis from Withania somnifera: chemotype-specific and elicitor-responsive expression.
PubMed: Withania somnifera leaf alleviates cognitive dysfunction by enhancing hippocampal plasticity in high fat diet induced obesity model.
PubMed: Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction.
PubMed: Withania somnifera as a potential anxiolytic and immunomodulatory agent in acute sleep deprived female Wistar rats.
PubMed: WSA206, a paralog of duplicated MPF2-like MADS-box family is recruited in fertility function in Withania.
PubMed: Natural product HTP screening for attenuation of cytokine-induced neutrophil chemo attractants (CINCs) and NO2- in LPS/IFNγ activated glioma cells.
PubMed: Novel Methods to Generate Active Ingredients-Enriched Ashwagandha Leaves and Extracts.
PubMed: Withanolides against TLR4-Activated Innate Inflammatory Signalling Pathways: A Comparative Computational and Experimental Study.
PubMed: Natural product HTP screening for antibacterial (E.coli 0157:H7) and anti-inflammatory agents in (LPS from E. coli O111:B4) activated macrophages and microglial cells; focus on sepsis.
PubMed: Over-expression of DXS gene enhances terpenoidal secondary metabolite accumulation in rose-scented geranium and Withania somnifera: active involvement of plastid isoprenogenic pathway in their biosynthesis.
PubMed: Anxiolytic, antidepressant, and antistress activities of the aqueous extract of Cinnamomum tamala Nees and Eberm in rats.
PubMed: Leaf spot disease adversely affects human health-promoting constituents and withanolide biosynthesis in Withania somnifera (L.) Dunal.
PubMed: A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain.
PubMed: Aqueous extract from the Withania somnifera leaves as a potential anti-neuroinflammatory agent: a mechanistic study.
PubMed: Quantitative determination of multi markers in five varieties of Withania somnifera using ultra-high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometer combined with multivariate analysis: Application to pharmaceutical dosage forms.
PubMed: In silico binding analysis of Withanolides with the Human GM-CSFR.
PubMed: Antiproliferative Activity of the Methanolic Extract of Withania Somnifera Leaves from Faifa Mountains, Southwest Saudi Arabia, against Several Human Cancer Cell Lines.
PubMed: Aqueous Leaf Extract of Withania somnifera as a Potential Neuroprotective Agent in Sleep-deprived Rats: a Mechanistic Study.
PubMed: Withania somnifera Leaf Extract Ameliorates Benzo[a]pyrene-Induced Behavioral and Neuromorphological Alterations by Improving Brain Antioxidant Status in Zebrafish (Danio rerio).
PubMed: Elicitation Approaches for Withanolide Production in Hairy Root Culture of Withania somnifera (L.) Dunal.
PubMed: Evaluating the inhibitory potential of Withania somnifera on platelet aggregation and inflammation enzymes: An in vitro and in silico study.
PubMed: Comparative transcriptome analysis of different chemotypes elucidates withanolide biosynthesis pathway from medicinal plant Withania somnifera.
PubMed: Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by Withania somnifera Leaf Extract.
PubMed: Ectopic overexpression of WsSGTL1, a sterol glucosyltransferase gene in Withania somnifera, promotes growth, enhances glycowithanolide and provides tolerance to abiotic and biotic stresses.
PubMed: Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity.
PubMed: Antimicrobial activity of cream incorporated with silver nanoparticles biosynthesized from Withania somnifera.
PubMed: Potential Anticancer Properties and Mechanisms of Action of Withanolides.
PubMed: Withania somnifera aqueous extract facilitates the expression and release of GnRH: In vitro and in vivo study.
PubMed: Accumulation of three important bioactive compounds in different plant parts of Withania somnifera and its determination by the LC-ESI-MS-MS (MRM) method.
PubMed: Micromorphology, histochemistry and ultrastructure of the foliar trichomes of Withania somnifera (L.) Dunal (Solanaceae).
PubMed: Antibacterial activity of Withania somnifera against Gram-positive isolates from pus samples.
PubMed: An evidence-based approach to the evaluation of ethnoveterinary medicines against strongyle nematodes of equids.
PubMed: Anticancer activities of Withania somnifera: Current research, formulations, and future perspectives.
PubMed: The traditional use of plants to manage candidiasis and related infections in Venda, South Africa.
PubMed: Virus-induced gene silencing of Withania somnifera squalene synthase negatively regulates sterol and defence-related genes resulting in reduced withanolides and biotic stress tolerance.
PubMed: Hypoglycemic activity of withanolides and elicitated Withania somnifera.
PubMed: Physiological performance, secondary metabolite and expression profiling of genes associated with drought tolerance in Withania somnifera.
PubMed: Light and auxin responsive cytochrome P450s from Withania somnifera Dunal: cloning, expression and molecular modelling of two pairs of homologue genes with differential regulation.
PubMed: Analysis of arsenic induced physiological and biochemical responses in a medicinal plant, Withania somnifera.
PubMed: Evaluation of some medicinal plants in controlling Culex pipiens.
PubMed: Transcriptome analysis reveals in vitro cultured Withania somnifera leaf and root tissues as a promising source for targeted withanolide biosynthesis.
PubMed: Improved Agrobacterium rhizogenes-mediated hairy root culture system of Withania somnifera (L.) Dunal using sonication and heat treatment.
PubMed: Estimation of Anticipated Performance Index and Air Pollution Tolerance Index and of vegetation around the marble industrial areas of Potwar region: bioindicators of plant pollution response.
PubMed: Effect of iron stress on Withania somnifera L.: antioxidant enzyme response and nutrient elemental uptake of in vitro grown plants.
PubMed: Preventive effects of withaferin A isolated from the leaves of an Indian medicinal plant Withania somnifera (L.): comparisons with 17-β-estradiol and alendronate.
PubMed: Molecular characterization of two A-type P450s, WsCYP98A and WsCYP76A from Withania somnifera (L.) Dunal: expression analysis and withanolide accumulation in response to exogenous elicitations.
PubMed: Secondary metabolites and phenylpropanoid pathway enzymes as influenced under supplemental ultraviolet-B radiation in Withania somnifera Dunal, an indigenous medicinal plant.
PubMed: [Hair roots induction and culture of Withania somnifera and its withanolide A synthesis].
PubMed: Withaferin A modulates the Spindle assembly checkpoint by degradation of Mad2-Cdc20 complex in colorectal cancer cell lines.
PubMed: Glioprotective effects of Ashwagandha leaf extract against lead induced toxicity.
PubMed: Cloning and functional characterization of three branch point oxidosqualene cyclases from Withania somnifera (L.) dunal.
PubMed: Sterol partitioning by HMGR and DXR for routing intermediates toward withanolide biosynthesis.
PubMed: Characterization of Withania somnifera leaf transcriptome and expression analysis of pathogenesis-related genes during salicylic acid signaling.
PubMed: Laboratory assessment of acaricidal activity of Cymbopogon winterianus, Vitex negundo and Withania somnifera extracts against deltamethrin resistant Hyalomma anatolicum.
PubMed: WsSGTL1 gene from Withania somnifera, modulates glycosylation profile, antioxidant system and confers biotic and salt stress tolerance in transgenic tobacco.
PubMed: Photosensitized synthesis of silver nanoparticles using Withania somnifera leaf powder and silver nitrate.
PubMed: Probing of metabolites in finely powdered plant material by direct laser desorption ionization mass spectrometry.
PubMed: Copper-stress induced alterations in protein profile and antioxidant enzymes activities in the in vitro grown Withania somnifera L.
PubMed: 5,6-de-epoxy-5-en-7-one-17-hydroxy withaferin A, a new cytotoxic steroid from Withania somnifera L. Dunal leaves.
PubMed: Investigation of heavy metals in frequently utilized medicinal plants collected from environmentally diverse locations of north western India.
PubMed: Dynamics of withanolide biosynthesis in relation to temporal expression pattern of metabolic genes in Withania somnifera (L.) Dunal: a comparative study in two morpho-chemovariants.
PubMed: Epoxide group relationship with cytotoxicity in withanolide derivatives from Withania somnifera.
PubMed: Acaricidal activity of Cymbopogon winterianus, Vitex negundo and Withania somnifera against synthetic pyrethroid resistant Rhipicephalus (Boophilus) microplus.
PubMed: Distribution of withaferin A, an anticancer potential agent, in different parts of two varieties of Withania somnifera (L.) Dunal. grown in Sri Lanka.
PubMed: Tropine forming tropinone reductase gene from Withania somnifera (Ashwagandha): biochemical characteristics of the recombinant enzyme and novel physiological overtones of tissue-wide gene expression patterns.
PubMed: Molecular targets and mechanisms of cancer prevention and treatment by withaferin a, a naturally occurring steroidal lactone.
PubMed: De novo assembly, functional annotation and comparative analysis of Withania somnifera leaf and root transcriptomes to identify putative genes involved in the withanolides biosynthesis.
PubMed: Effect of plant secondary compounds on in vitro methane, ammonia production and ruminal protozoa population.
PubMed: NADPH-cytochrome P450 reductase: molecular cloning and functional characterization of two paralogs from Withania somnifera (L.) dunal.
PubMed: An in vitro study of apoptotic like death in Leishmania donovani promastigotes by withanolides.
PubMed: Molecular characterization and promoter analysis of squalene epoxidase gene from Withania somnifera (L.) Dunal.
PubMed: Methanolic extracts of Withania somnifera leaves, fruits and roots possess antioxidant properties and antibacterial activities.
PubMed: Differential activities of the two closely related withanolides, Withaferin A and Withanone: bioinformatics and experimental evidences.
PubMed: Qualitative and quantitative variations in withanolides and expression of some pathway genes during different stages of morphogenesis in Withania somnifera Dunal.
PubMed: Optimization of elicitation conditions with methyl jasmonate and salicylic acid to improve the productivity of withanolides in the adventitious root culture of Withania somnifera (L.) Dunal.
PubMed: Carbohydrate and elicitor enhanced withanolide (withaferin A and withanolide A) accumulation in hairy root cultures of Withania somnifera (L.).
PubMed: [Plant regeneration of Withania somnifera].
PubMed: Sterol glycosyltransferases-identification of members of gene family and their role in stress in Withania somnifera.
PubMed: Functional characterization and differential expression studies of squalene synthase from Withania somnifera.
PubMed: Evaluation of antimicrobial efficacy of flavonoids of withania somnifera L.
PubMed: Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity.
PubMed: Cloning and characterization of 2-C-methyl-D-erythritol-4-phosphate pathway genes for isoprenoid biosynthesis from Indian ginseng, Withania somnifera.
PubMed: Molecular cloning, bacterial expression and promoter analysis of squalene synthase from Withania somnifera (L.) Dunal.
PubMed: Application of HR-MAS NMR spectroscopy for studying chemotype variations of Withania somnifera (L.) Dunal.
PubMed: Comparative larvicidal potential of different plant parts of Withania somnifera against vector mosquitoes in the semi-arid region of Rajasthan.
PubMed: High catechin concentrations detected in Withania somnifera (ashwagandha) by high performance liquid chromatography analysis.
PubMed: Metabolic characterization of Withania somnifera from different regions of India using NMR spectroscopy.
PubMed: Ashwagandha leaf derived withanone protects normal human cells against the toxicity of methoxyacetic acid, a major industrial metabolite.
PubMed: Management of Parthenium hysterophorus (Asteraceae) by Withania somnifera (Solanaceae).
PubMed: Reversal of Cadmium-induced Oxidative Stress in Chicken by Herbal Adaptogens Withania Somnifera and Ocimum Sanctum.
PubMed: Scientific basis for the use of Indian ayurvedic medicinal plants in the treatment of neurodegenerative disorders: ashwagandha.
PubMed: Comprehensive metabolic fingerprinting of Withania somnifera leaf and root extracts.
PubMed: Antioxidant effect of dietary supplement Withania somnifera L. reduce blood glucose levels in alloxan-induced diabetic rats.
PubMed: Agrobacterium tumefaciens-mediated transformation of Withania somnifera (L.) Dunal: an important medicinal plant.
PubMed: Production dynamics of Withaferin A in Withania somnifera (L.) Dunal complex.
PubMed: Generation and analysis of expressed sequence tags from leaf and root of Withania somnifera (Ashwgandha).
PubMed: Molecular insight into the immune up-regulatory properties of the leaf extract of Ashwagandha and identification of Th1 immunostimulatory chemical entity.
PubMed: Effect of the alcoholic extract of Ashwagandha leaves and its components on proliferation, migration, and differentiation of glioblastoma cells: combinational approach for enhanced differentiation.
PubMed: Hypoglycaemic and hypolipidaemic effects of Withania somnifera root and leaf extracts on alloxan-induced diabetic rats.
PubMed: Ashwagandha leaf extract: a potential agent in treating oxidative damage and physiological abnormalities seen in a mouse model of Parkinson's disease.
PubMed: Protection of swimming-induced oxidative stress in some vital organs by the treatment of composite extract of Withania somnifera, Ocimum sanctum and Zingiber officinalis in male rat.
PubMed: Studies on leaf spot disease of Withania somnifera and its impact on secondary metabolites.
PubMed: Purification of a lectin-like antifungal protein from the medicinal herb, Withania somnifera.
PubMed: Establishment of Withania somnifera hairy root cultures for the production of withanolide A.
PubMed: In vitro withanolide production by Withania somnifera L. cultures.
PubMed: Withanolide A is inherently de novo biosynthesized in roots of the medicinal plant Ashwagandha (Withania somnifera).
PubMed: Analysis of withanolides in root and leaf of Withania somnifera by HPLC with photodiode array and evaporative light scattering detection.
PubMed: Purification and characterization of a novel glucosyltransferase specific to 27beta-hydroxy steroidal lactones from Withania somnifera and its role in stress responses.
PubMed: Genetic and phytochemical difference between some Indian and Italian plants of Withania somnifera (L.) Dunal.
PubMed: Anti-malarial activity of withania somnifera L. Dunal extracts in mice.
PubMed: Total phenol, antioxidant and free radical scavenging activities of some medicinal plants.
PubMed: Withanolide induces apoptosis in HL-60 leukemia cells via mitochondria mediated cytochrome c release and caspase activation.
PubMed: Molecular cloning and characterization of one member of 3beta-hydroxy sterol glucosyltransferase gene family in Withania somnifera.
PubMed: Purification and physico-kinetic characterization of 3beta-hydroxy specific sterol glucosyltransferase from Withania somnifera (L) and its stress response.
PubMed: In Vivo antimalarial activity of aqueous extracts from Kenyan medicinal plants and their chloroquine (CQ) potentiation effects against a blood-induced CQ-resistant rodent parasite in mice.
PubMed: Free radical scavenging activity of different parts of withania somnifera.
PubMed: Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.
PubMed: Antimalarial activity of methanolic extracts from plants used in Kenyan ethnomedicine and their interactions with chloroquine (CQ) against a CQ-tolerant rodent parasite, in mice.
PubMed: Inhibition of aflatoxin B production of Aspergillus flavus, isolated from soybean seeds by certain natural plant products.
PubMed: Phytochemical and genetic analysis in selected chemotypes of Withania somnifera.
PubMed: Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression.
PubMed: Unusually sulfated and oxygenated steroids from Withania somnifera.
PubMed: In vitro enzyme inhibition activities of crude ethanolic extracts derived from medicinal plants of Pakistan.
PubMed: Antibacterial efficacy of Withania somnifera (ashwagandha) an indigenous medicinal plant against experimental murine salmonellosis.
PubMed: Genetically modified hairy roots of Withania somnifera Dunal: a potent source of rejuvenating principles.
PubMed: Evaluation of the anti-proliferative and anti-oxidative activities of leaf extract from in vivo and in vitro raised Ashwagandha.
PubMed: The in vitro antibacterial/synergistic activities of Withania somnifera extracts.
PubMed: Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves.
PubMed: Quantitative HPLC analysis of withanolides in Withania somnifera.
PubMed: Microorganisms asssociated with Withania somnifera leaves.
PubMed: Positive growth responses of the medicinal plants Spilanthes calva and Withania somnifera to inoculation by Piriformospora indica in a field trial.
PubMed: In vitro propagation of Withania somnifera and isolation of withanolides with immunosuppressive activity.
PubMed: Modification of bone marrow radiosensensitivity by medicinal plant extracts.
PubMed: Pharmacological studies on leaves of Withania somnifera.
PubMed: Comments on the activity of some constitutents of Withania somnifera Dun. I. The antibacterial activity of five nitrogen-free substances isolated from the leaves.
PubMed: [Chemotherapeutic properties of substances isolated from leaves of Withania somnifera Dunal].
Synonyms   Articles   Notes   Search   Top
Please share your Comments.
Email Address:
 
 
 
 
Top of Page Home
Copyright © 1980-2020 Perflavory ™ Disclaimer Privacy Policy