sanguinaria canadensis root extract
extract of the roots of the blood root, sanguinaria canadensis l., papaveraceae
 
Notes:
None found
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Name: sanguinaria canadensis l. root extract
CAS Number: 84929-48-6 
ECHA EC Number: 284-532-0
Category: cosmetic ingredient for skin conditioning
 
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Physical Properties:
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
CosIng: cosmetic data
Cosmetic Uses: skin conditioning
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
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Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: cosmetic ingredient for skin conditioning
Recommendation for sanguinaria canadensis root extract usage levels up to:
 not for fragrance use.
 
Recommendation for sanguinaria canadensis root extract flavor usage levels up to:
 not for flavor use.
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Safety References:
Daily Med: search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
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National Institute of Allergy and Infectious Diseases: Data
 sanguinaria canadensis l. root extract
Chemidplus: 0084929486
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References:
 sanguinaria canadensis l. root extract
Pubchem (sid): 135326333
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Other Information:
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 sanguinaria canadensis root
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Synonyms:
 blood root extract
 bloodroot root extract
 extract of the roots of the blood root, sanguinaria canadensis l., papaveraceae
red-puccoon root extract
 sanguinaria australis root extract
 sanguinaria canadensis var. rotundifolia root extract
 sanguinaria dilleniana root extract
 sanguinaria root extract
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Articles:
PubMed: Sanguinarine Induces Apoptosis of Human Oral Squamous Cell Carcinoma KB Cells via Inactivation of the PI3K/Akt Signaling Pathway.
PubMed: Antitumor effects of the benzophenanthridine alkaloid sanguinarine: Evidence and perspectives.
PubMed: Apoptotic Effects of Sanguinarine on the Organ of Corti 1 Cells: Comparison with Cisplatin.
PubMed: Rapid human melanoma cell death induced by sanguinarine through oxidative stress.
PubMed: Consequences of intratumoral injection of a herbal preparation containing blood root (Sanguinaria canadensis) extract in two dogs.
PubMed: The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus.
PubMed: An Internet misadventure: bloodroot salve toxicity.
PubMed: Bloodroot (Sanguinaria canadensis L., Papaveraceae) Enhances Proliferation and Cytokine Production by Human Peripheral Blood Mononuclear Cells in an In Vitro Model.
PubMed: Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis via down-regulation of AKT and activation of caspase-3.
PubMed: In vitro screening for the tumoricidal properties of international medicinal herbs.
PubMed: Sanguinarine-induced apoptosis in human leukemia U937 cells via Bcl-2 downregulation and caspase-3 activation.
PubMed: Sanguinarine-induced apoptosis: generation of ROS, down-regulation of Bcl-2, c-FLIP, and synergy with TRAIL.
PubMed: Effects of aqueous extracts from five species of the family Papaveraceae on selected aquatic organisms.
PubMed: Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt.
PubMed: Sanguinarine inhibits VEGF-induced angiogenesis in a fibrin gel matrix.
PubMed: Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization.
PubMed: Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production.
PubMed: Suppression of angiogenesis by the plant alkaloid, sanguinarine.
PubMed: Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes.
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