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Category: cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Soluble in: |
| | water, 1.09E+04 mg/L @ 20 °C (exp) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-dog LD > 4000 mg/kg GASTROINTESTINAL: NAUSEA OR VOMITING
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 19, 1990.
intraperitoneal-mouse LD50 1250 mg/kg SKIN AND APPENDAGES (SKIN): HAIR: OTHER
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.
intravenous-mouse LD50 > 200 mg/kg Drugs in Japan Vol. -, Pg. 1195, 1995.
oral-mouse LD50 5600 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.
intraperitoneal-rat LD50 1670 mg/kg GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.
intravenous-rat LD50 > 200 mg/kg Drugs in Japan Vol. -, Pg. 1195, 1995.
oral-rat LD50 7050 mg/kg GASTROINTESTINAL: OTHER CHANGES
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
LUNGS, THORAX, OR RESPIRATION: DYSPNEA Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.
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| Dermal Toxicity: |
subcutaneous-mouse LD50 > 4000 mg/kg Drugs in Japan Vol. -, Pg. 1195, 1995.
subcutaneous-rat LD50 > 4000 mg/kg SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | cosmetic ingredient for skin conditioning |
| Recommendation for propagermanium usage levels up to: | | | not for fragrance use.
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| Recommendation for propagermanium flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA Substance Registry Services (TSCA): | 12758-40-6 |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 83030 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| | 3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid |
| Chemidplus: | 0012758406 |
| RTECS: | UA2459750 for cas# 12758-40-6 |
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 3-[[2- | carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid | | 3,3'-(1,3- | dioxo-1,3-digermoxanediyl)dipropionic acid; 3,3'-(dioxodigermoxanylene) dipropanoic acid; germanate(2-), bis(2-carboxylatoethyl)trioxodi-, dihydrogen | | | propanoic acid, 3,3'-(1,3-dioxo-1,3-digermoxanediyl)bis- |
Articles:
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