| Google Patents: | Use of icariside II in manufacture of products for preventing or treating male or female sexual dysfunction |
| PubMed: | Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats. |
| PubMed: | Icariside II, a natural mTOR inhibitor, disrupts aberrant energy homeostasis via suppressing mTORC1-4E-BP1 axis in sarcoma cells. |
| PubMed: | Preparation and evaluation of icariside II-loaded binary mixed micelles using Solutol HS15 and Pluronic F127 as carriers. |
| PubMed: | Optimized Biotransformation of Icariin into Icariside II by β-Glucosidase from Trichoderma viride Using Central Composite Design Method. |
| PubMed: | Icariside II protects against cerebral ischemia-reperfusion injury in rats via nuclear factor-κB inhibition and peroxisome proliferator-activated receptor up-regulation. |
| PubMed: | Icariside II inhibits the EMT of NSCLC cells in inflammatory microenvironment via down-regulation of Akt/NF-κB signaling pathway. |
| PubMed: | Beneficial Effects of a Flavonoid Fraction of Herba Epimedii on Bone Metabolism in Ovariectomized Rats. |
| PubMed: | Metabolite Profiles of Icariin in Rat Feces, Bile and Urine by Ultraperformance Liquid-Chromatography/Quadrupole-Time-of-Flight Mass Spectrometry. |
| PubMed: | [HPLC-PDA-CAD Fingerprints of Salt Anemarrhenae Rhizoma]. |
| PubMed: | [Quality Analysis and Evaluation of Anemarrhena asphodeloides Rhizome from Different Habitats]. |
| PubMed: | Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15. |
| PubMed: | Comparative Pharmacokinetics Study of Icariin and Icariside II in Rats. |
| PubMed: | Evaluation of medicinal value of Epimedium elatum on the basis of pharmacologically active constituents, Icariin and Icariside-II. |
| PubMed: | Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats. |
| PubMed: | [Optimization of extraction technology of compatibility of couplet medicines Epimedium brevicornu and Ligusticum chuanxiong by orthogonal design]. |
| PubMed: | TPGS/Phospholipids Mixed Micelles for Delivery of Icariside II to Multidrug-Resistant Breast Cancer. |
| PubMed: | Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells. |
| PubMed: | Icariside II promotes osteogenic differentiation of bone marrow stromal cells in beagle canine. |
| PubMed: | Icariside II-induced mitochondrion and lysosome mediated apoptosis is counterbalanced by an autophagic salvage response in hepatoblastoma. |
| PubMed: | Regio-selective deglycosylation of icariin by cell suspension cultures of Glycyrrhiza uralensis and Morus alba. |
| PubMed: | Anti-Androgenic Activity of Icarisid II from Epimedium Herb in Prostate Cancer LNCaP Cells. |
| PubMed: | [Optimization of process of icraiin be hydrolyzed to Baohuoside I by cellulase based on Plackett-Burman design combined with CCD response surface methodology]. |
| PubMed: | Antioxidant icariside II combined with insulin restores erectile function in streptozotocin-induced type 1 diabetic rats. |
| PubMed: | Icariside II prevents high-glucose-induced injury on human cavernous endothelial cells through Akt-eNOS signaling pathway. |
| PubMed: | Bu-Shen-Yi-Qi formulae suppress chronic airway inflammation and regulate Th17/Treg imbalance in the murine ovalbumin asthma model. |
| PubMed: | Effects of Icariside II on corpus cavernosum and major pelvic ganglion neuropathy in streptozotocin-induced diabetic rats. |
| PubMed: | Synergistic inhibitory effect of Icariside II with Icaritin from Herba Epimedii on pre-osteoclastic RAW264.7 cell growth. |
| PubMed: | Baohuoside I suppresses invasion of cervical and breast cancer cells through the downregulation of CXCR4 chemokine receptor expression. |
| PubMed: | Implications for differentiation of endogenous stem cells: therapeutic effect from icariside II on a rat model of postprostatectomy erectile dysfunction. |
| PubMed: | Icariside II inhibits cell proliferation and induces cell cycle arrest through the ROS-p38-p53 signaling pathway in A375 human melanoma cells. |
| PubMed: | Prophylactic protective effects and its potential mechanisms of IcarisideII on streptozotocin induced spermatogenic dysfunction. |
| PubMed: | Rapid characterization and determination of multiple components in Bu-Shen-Yi-Qi-Fang by high-performance liquid chromatography coupled to electrospray ionization and quadrupole time-of-flight mass spectrometry. |
| PubMed: | [Two-dimensional zebrafish model combined with hyphenated chromatographic techniques for evaluation anti-osteoporosis activity of epimendin A and its metabolite baohuoside I]. |
| PubMed: | Blockade of epidermal growth factor receptor/mammalian target of rapamycin pathway by Icariside II results in reduced cell proliferation of osteosarcoma cells. |
| PubMed: | Ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry analysis of icariside II metabolites in rats. |
| PubMed: | Icariside II improves cerebral microcirculatory disturbance and alleviates hippocampal injury in gerbils after ischemia-reperfusion. |
| PubMed: | [Analysis on biotransformation of Epimedium brevicornu flavonoids]. |
| PubMed: | BuShenYiQi Formula strengthens Th1 response and suppresses Th2-Th17 responses in RSV-induced asthma exacerbated mice. |
| PubMed: | Flavonoids from Herba epimedii selectively activate estrogen receptor alpha (ERα) and stimulate ER-dependent osteoblastic functions in UMR-106 cells. |
| PubMed: | [Study on different factors affecting the bionic enzymatic hydrolysis of icariin]. |
| PubMed: | A comparative study on the metabolism of Epimedium koreanum Nakai-prenylated flavonoids in rats by an intestinal enzyme (lactase phlorizin hydrolase) and intestinal flora. |
| PubMed: | [Flavonoids from leaves of Epimedium pubescens]. |
| PubMed: | Icariside II induces apoptosis via inhibition of the EGFR pathways in A431 human epidermoid carcinoma cells. |
| PubMed: | Pharmacokinetic study of icariside II after a single dose administration of YiGu capsule in healthy Chinese volunteers. |
| PubMed: | [Effects of four kinds of Chinese medicine monomer on growth of PANC-1 xenograft tumor and studying of molecular mechanism]. |
| PubMed: | Effect of β-cyclodextrin complexation on solubility and enzymatic hydrolysis rate of icariin. |
| PubMed: | Icariside II reduces testosterone production by inducing necrosis in rat Leydig cells. |
| PubMed: | A new strategy for the discovery of epimedium metabolites using high-performance liquid chromatography with high resolution mass spectrometry. |
| PubMed: | [Affect regularity of medicinal species and heating time on flavonoids contents in Epimedium cut crude drug]. |
| PubMed: | Icariside II induces apoptosis of melanoma cells through the downregulation of survival pathways. |
| PubMed: | [Screening of bioactive components in epimedium for osteoporosis treatment by model population analysis]. |
| PubMed: | Drug-Drug Interactions Potential of Icariin and Its Intestinal Metabolites via Inhibition of Intestinal UDP-Glucuronosyltransferases. |
| PubMed: | A novel drug-phospholipid complex loaded micelle for baohuoside I enhanced oral absorption: in vivo and in vivo evaluations. |
| PubMed: | Preparation of a nanoscale baohuoside I-phospholipid complex and determination of its absorption: in vivo and in vitro evaluations. |
| PubMed: | [Comparative study on chemical quality of main species of epimedium]. |
| PubMed: | Herba epimedii flavonoids suppress osteoclastic differentiation and bone resorption by inducing G2/M arrest and apoptosis. |
| PubMed: | Induction of apoptosis by Icariside II through extrinsic and intrinsic signaling pathways in human breast cancer MCF7 cells. |
| PubMed: | Functions and action mechanisms of flavonoids genistein and icariin in regulating bone remodeling. |
| PubMed: | Icariside II potentiates paclitaxel-induced apoptosis in human melanoma A375 cells by inhibiting TLR4 signaling pathway. |
| PubMed: | Effect of icarisid II on diabetic rats with erectile dysfunction and its potential mechanism via assessment of AGEs, autophagy, mTOR and the NO-cGMP pathway. |
| PubMed: | Reactive oxygen species-mediated mitochondrial pathway is involved in Baohuoside I-induced apoptosis in human non-small cell lung cancer. |
| PubMed: | Preparation of icariside II-phospholipid complex and its absorption across Caco-2 cell monolayers. |
| PubMed: | Metabolite profiles of icariin in rat plasma by ultra-fast liquid chromatography coupled to triple-quadrupole/time-of-flight mass spectrometry. |
| PubMed: | Icariside II induces apoptosis in U937 acute myeloid leukemia cells: role of inactivation of STAT3-related signaling. |
| PubMed: | Effects of icariside II on improving erectile function in rats with streptozotocin-induced diabetes. |
| PubMed: | Influence of vitamin E tocopherol polyethylene glycol succinate 1000 on intestinal absorption of icariside II. |
| PubMed: | Metabolite profiling of four major flavonoids of Herba Epimedii in zebrafish. |
| PubMed: | Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. |
| PubMed: | Icariside II enhances Nrf2 nuclear translocation to upregulate phase II detoxifying enzyme expression coupled with the ERK, Akt and JNK signaling pathways. |
| PubMed: | [Effects of icariin and icariside II on eNOS expression and NOS activity in porcine aorta endothelial cells]. |
| PubMed: | The flavonoid Baohuoside-I inhibits cell growth and downregulates survivin and cyclin D1 expression in esophageal carcinoma via β-catenin-dependent signaling. |
| PubMed: | [The changes of iNOS and NO in the osteogenic differentiation process of rat bone marrow stromal cells promoted by icariside II]. |
| PubMed: | Icarisid II, a PDE5 inhibitor from Epimedium wanshanense, increases cellular cGMP by enhancing NOS in diabetic ED rats corpus cavernosum tissue. |
| PubMed: | [Comparative study on the osteogenic differentiation of rat bone marrow stromal cells effected by icariin and icariside II]. |
| PubMed: | Role of intestinal hydrolase in the absorption of prenylated flavonoids present in Yinyanghuo. |
| PubMed: | Janus activated kinase 2/signal transducer and activator of transcription 3 pathway mediates icariside II-induced apoptosis in U266 multiple myeloma cells. |
| PubMed: | [Quality research on Epimedium cut crude drug processed with oil]. |
| PubMed: | Simultaneous determination of seven flavonoids in dog plasma by ultra-performance liquid chromatography-tandem mass spectrometry and its application to a bioequivalence study of bioactive components in Herba Epimedii and Er-Xian Decoction. |
| PubMed: | Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflavonoids from Epimediums. |
| PubMed: | [Absorption and metabolism of flavonoids in Herba Epimedii via rat intestinal perfusion model]. |
| PubMed: | [Research on variation regularity of five main flavonoids contents in Epimedium and processed Epimedium]. |
| PubMed: | Preparation of icariside II from icariin by enzymatic hydrolysis method. |
| PubMed: | [Sampling in quality control of medicinal materials-A case of Epimedium]. |
| PubMed: | Pharmacokinetics of prenylflavonoids and correlations with the dynamics of estrogen action in sera following ingestion of a standardized Epimedium extract. |
| PubMed: | Cyclooxygenase-2/prostaglandin E2 pathway mediates icariside II induced apoptosis in human PC-3 prostate cancer cells. |
| PubMed: | Effect of stability of internal standard on quantification of 15 flavonoids in Epimedium using CZE. |
| PubMed: | Simple and sensitive liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of five Epimedium prenylflavonoids in rat sera. |
| PubMed: | Antiosteoporotic chemical constituents from Er-Xian Decoction, a traditional Chinese herbal formula. |
| PubMed: | Intestinal absorption mechanisms of prenylated flavonoids present in the heat-processed Epimedium koreanum Nakai (Yin Yanghuo). |
| PubMed: | Statistically designed enzymatic hydrolysis for optimized production of icariside II as a novel melanogenesis inhibitor. |
| PubMed: | Simultaneous determination of nine flavonoids and qualitative evaluation of Herba Epimedii by high performance liquid chromatography with ultraviolet detection. |
| PubMed: | Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC-MS/MS. |
| PubMed: | Icariside II from Epimedium koreanum inhibits hypoxia-inducible factor-1alpha in human osteosarcoma cells. |
| PubMed: | A rapid method for simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and ultra-performance liquid chromatography. |
| PubMed: | Icaritin and its glycosides enhance osteoblastic, but suppress osteoclastic, differentiation and activity in vitro. |
| PubMed: | LC-MS/MS method for the simultaneous determination of icariin and its major metabolites in rat plasma. |
| PubMed: | [Comparison of antioxidative and antitumor activities of six flavonoids from Epimedium koreanum]. |
| PubMed: | Simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and high-performance liquid chromatography. |
| PubMed: | Effect of Baohuoside-1 aglycone and tacrolimus monotherapy and combination therapy on prevention of acute heart allograft rejection in the rat. |
| PubMed: | Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development. |
| PubMed: | Baohuoside-1 inhibits activated T cell proliferation at G(1)-S phase transition. |
| PubMed: | Determination of rat urinary metabolites of icariin in vivo and estrogenic activities of its metabolites on MCF-7 cells. |
| PubMed: | Preparative isolation and purification of three flavonoids from the Chinese medicinal plant Epimedium koreamum Nakai by high-speed counter-current chromatography. |
| PubMed: | Baohuoside-1, a novel immunosuppressive molecule, inhibits lymphocyte activation in vitro and in vivo. |
| PubMed: | [Chemical constituents of the root of Epimedium acumiantum Franch]. |
| PubMed: | Isolation and immunomodulatory effect of flavonol glycosides from Epimedium hunanense. |
| PubMed: | Flavonoids from Epimedium wanshanense. |
| PubMed: | [Chemical constituents from the aerial part of Epimedium brevicornum Maxim]. |
| PubMed: | Immunopharmacology and toxicology of the plant flavonoid baohuoside-1 in mice. |
| PubMed: | [Studies on the chemical constituents of Epimedium acuminatum Franch]. |
| PubMed: | In vitro immunopharmacological profile of the plant flavonoid baohuoside-1. |
| PubMed: | Effects of the plant flavonoid baohuoside-1 on cancer cells in vitro. |
| PubMed: | [Studies on the isolations and structures of baohuosides-I, VI, VII and baohuosu]. |