Articles:
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L-gamma- glutamyl-L-cysteinyl-, (2,2')-disulfide
Notes:
Glutathione disulfide (GSSG) - oxidized glutathione - is a disulfide derived from two glutathione molecules. In living cells, glutathione disulfide is reduced into two molecules of glutathione with reducing equivalents from the coenzyme NADPH. This reaction is catalyzed by the enzyme glutathione reductase. [Wikipedia]
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| CAS Number: | 27025-41-8 |  3D/inchi
|
| Other(deleted CASRN): | 10421-65-5 | |
| ECHA EINECS - REACH Pre-Reg: | 248-170-7 | |
| FDA UNII: | ULW86O013H | |
| Nikkaji Web: | J415.688I | |
| Beilstein Number: | 1718700 | |
| MDL: | MFCD00063106 | |
| XlogP3-AA: | -9.10 (est) | |
| Molecular Weight: | 612.63744000 | |
| Formula: | C20 H32 N6 O12 S2 | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: emollients, skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Soluble in: | |
| water, 3.002e+005 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| CosIng: | cosmetic data |
| Cosmetic Uses: |
skin conditioning skin conditioning - emollient |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Glutathione Impurity C >98%
Odor: characteristic Use: NOV-002 is a stabilized formulation of disodium glutathione disulfide (GSSG; oxidized glutathione) and cisplatin (1000:1) with potential chemoprotective and immunomodulating activities. |
| EMD Millipore |
| For experimental / research use only. |
| Glutathione, Oxidized, Free Acid |
| Glentham Life Sciences |
| L-Glutathione oxidised, 98% |
| Jiangyin Healthway |
| Oxidized Glutathione |
| New functional food ingredients |
| Meafo |
| For experimental / research use only. |
| L-Glutathione oxidized 98% |
| Santa Cruz Biotechnology |
| For experimental / research use only. |
| Glutathione, oxidized ≥95% |
| Sigma-Aldrich: Sigma |
| For experimental / research use only. |
| L-Glutathione oxidized ≥98% (HPLC) |
| TCI AMERICA |
| For experimental / research use only. |
| Glutathione oxidized form >98.0%(HPLC) |
Safety Information:
| Preferred SDS: View | |
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
intravenous-mouse LD50 > 2000 mg/kg Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. oral-mouse LD50 > 5000 mg/kg Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. intravenous-rat LD50 > 2000 mg/kg Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. oral-rat LD50 > 5000 mg/kg Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 > 2000 mg/kg Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. subcutaneous-rat LD50 > 2000 mg/kg Kiso to Rinsho. Clinical Report. Vol. 23, Pg. 6793, 1989. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | emollients, skin conditioning | ||
| Recommendation for oxidised glutathione usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for oxidised glutathione flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| ClinicalTrials.gov: | search |
| Daily Med: | search |
| Chemical Carcinogenesis Research Information System: | Search |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA GENetic TOXicology: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 65359 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 2 |
| Chemidplus: | 0027025418 |
| RTECS: | MC0556500 for cas# 27025-41-8 |
References:
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 65359 |
| Pubchem (sid): | 135022908 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| KEGG (GenomeNet): | C00127 |
| HMDB (The Human Metabolome Database): | HMDB03337 |
| FooDB: | FDB023147 |
| Export Tariff Code: | 2937.19.0000 |
| ChemSpider: | View |
| Wikipedia: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| not found in nature |
Synonyms:
| bi(glutathion-S-yl) | |
| N,N'-( | dithiobis(1-((carboxymethyl)carbamoyl)ethylene))di-, L- |
| L-gamma- | glutamyl-L-cysteinyl-, (2,2')-disulfide |
| L-oxidized | glutathione |
| glutathione disulfide | |
| oxiglutationa | |
| oxigluthione |