aristolochic acids
 
Notes:
Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine ( APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator ( ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy ( NEPHRITIS). There is no relationship to the similar named aristolochene ( SESQUITERPENES).
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Category: natural substances and extractives
 
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for aristolochic acids usage levels up to:
 not for fragrance use.
 
Recommendation for aristolochic acids flavor usage levels up to:
 not for flavor use.
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Safety References:
AIDS Citations: Search
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References:
None found
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Other Information:
VCF-Online: VCF Volatile Compounds in Food
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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Synonyms:
 aristolochic acids
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Articles:
PubMed: Determination of aristolochic acids by high-performance liquid chromatography with fluorescence detection.
PubMed: Quantification of aristolochic acids I and II in herbal dietary supplements by ultra-high-performance liquid chromatography-multistage fragmentation mass spectrometry.
PubMed: Molecular identification and cytotoxicity study of herbal medicinal materials that are confused by Aristolochia herbs.
PubMed: Evaluating the weak in vivo micronucleus response of a genotoxic carcinogen, aristolochic acids.
PubMed: Risk assessment of upper tract urothelial carcinoma related to aristolochic acid.
PubMed: Potential genotoxicity of traditional chinese medicinal plants and phytochemicals: an overview.
PubMed: Novel assays for detection of urinary KIM-1 in mouse models of kidney injury.
PubMed: Identification of Baiying (Herba Solani Lyrati) commodity and its toxic substitute Xungufeng (Herba Aristolochiae Mollissimae) using DNA barcoding and chemical profiling techniques.
PubMed: Possible health impacts of naturally occurring uptake of aristolochic acids by maize and cucumber roots: links to the etiology of endemic (Balkan) nephropathy.
PubMed: ACB-PCR measurement of H-ras codon 61 CAA→CTA mutation provides an early indication of aristolochic acid I carcinogenic effect in tumor target tissues.
PubMed: Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction.
PubMed: The molecular mechanism of leptin secretion and expression induced by aristolochic acid in kidney fibroblast.
PubMed: Chinese herbal medicines, aristolochic acid and Balkan endemic nephropathy.
PubMed: Occupational kidney disease among Chinese herbalists exposed to herbs containing aristolochic acids.
PubMed: «Suspects» in etiology of endemic nephropathy: aristolochic acid versus mycotoxins.
PubMed: Early detection of Balkan endemic nephropathy in Bosanska Posavina.
PubMed: Isolation of a new monoterpenic ester from the leaves of Michelia compressa (Maxim.) Sargent var. formosana Kanehira (Magnoliaceae).
PubMed: Ochratoxin A and aristolochic acid involvement in nephropathies and associated urothelial tract tumours.
PubMed: Microarray platform consistency is revealed by biologically functional analysis of gene expression profiles.
PubMed: TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours.
PubMed: Risky pills: supplements to avoid.
PubMed: Aristolochic acid nephropathy: a worldwide problem.
PubMed: Mycotoxic and aristolochic acid theories of the development of endemic nephropathy.
PubMed: Antagonistic, stage-specific selection on defensive chemical sequestration in a toxic butterfly.
PubMed: Short-term toxicity of aristolochic acid, aristolochic acid-I and aristolochic acid-II in rats.
PubMed: New molecular and field evidences for the implication of mycotoxins but not aristolochic acid in human nephropathy and urinary tract tumor.
PubMed: Enforcement of the ban on aristolochic acids in Chinese traditional herbal preparations on the Dutch market.
PubMed: [Study on transdifferentiation of renal tubular cells in rat chronic renal interstitial fibrosis induced by Radix Aristolochiae Fangchi Extract].
PubMed: Subchronic toxicity studies of the aqueous extract of Aristolochiae fructus in Sprague-Dawley rats.
PubMed: Aristolochic acid-induced cell cycle G1 arrest in human urothelium SV-HUC-1 cells.
PubMed: A novel trade-off of insect diapause affecting a sequestered chemical defense.
PubMed: Mutations induced by carcinogenic doses of aristolochic acid in kidney of Big Blue transgenic rats.
PubMed: A sensitive enzyme-linked immunosorbent assay for detecting carcinogenic aristolochic acid in herbal remedies.
PubMed: NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats.
PubMed: Induction of urothelial proliferation in rats by aristolochic acid through cell cycle progression via activation of cyclin D1/cdk4 and cyclin E/cdk2.
PubMed: Analysis of aristolochic acids and analogues in medicinal plants and their commercial products by HPLC-PAD-ESI/MS.
PubMed: Molecular mechanisms of toxicity of important food-borne phytotoxins.
PubMed: Application of simplified in vitro screening tests to detect genotoxicity of aristolochic acid.
PubMed: Dangerous supplements: still at large.
PubMed: NMR regulatory analysis: determination and characterization of Chinese-herb aristolochic acids.
PubMed: Aristolochic acid, an herbal carcinogen, sold on the Web after FDA alert.
PubMed: Detection of aristolochic acid in Chinese phytomedicines and dietary supplements used as slimming regimens.
PubMed: Determination of aristolochic acid I and II in North American species of Asarum and Aristolochia.
PubMed: High-performance liquid chromatographic determination for aristolochic acid in medicinal plants and slimming products.
PubMed: Selective adaptation to noxious foods by a herbivorous insect.
PubMed: From the Food and Drug Administration.
PubMed: A peripheral mechanism for behavioral adaptation to specific "bitter" taste stimuli in an insect.
PubMed: Herbal hazard.
PubMed: Cancer and herbs.
PubMed: [Traditional remedy-induced Chinese herbs nephropathy showing rapid deterioration of renal function].
PubMed: Aristolochic acids and aristolactams from the seeds of Aristolochia baetica.
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