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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 264.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 575.90 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 438.00 °F. TCC ( 225.30 °C. ) (est)
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| logP (o/w): | 3.310 (est) |
| Soluble in: |
| | water, 112.5 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for baicalein usage levels up to: | | | not for fragrance use.
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| Recommendation for baicalein flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | baikalein | | | biacalein | | | noroxylin | | 5,6,7- | trihydroxy-2-phenylchromen-4-one | | 5,6,7- | trihydroxyflavone |
Articles:
| PubMed: | Prophylactic effect of baicalein against renal dysfunction in type 2 diabetic rats. |
| PubMed: | Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice. |
| PubMed: | Differential effects of baicalein and its sulfated derivatives in inhibiting proliferation of human breast cancer MCF-7 cells. |
| PubMed: | [Baicalein induces HeLa cell growth inhibition by down-regulation of matrix metalloproteinases and activating extracellular signal-regulated kinase]. |
| PubMed: | Phenolic profile, antioxidant, anti-inflammatory and cytotoxic activities of black (Tuber aestivum Vittad.) and white (Tuber magnatum Pico) truffles. |
| PubMed: | Effects of chemopreventive natural products on non-homologous end-joining DNA double-strand break repair. |
| PubMed: | Baicalein modulates Nrf2/Keap1 system in both Keap1-dependent and Keap1-independent mechanisms. |
| PubMed: | Skullcap (Scutellaria baicalensis) extract and its active compound, wogonin, inhibit ovalbumin-induced Th2-mediated response. |
| PubMed: | Baicalein inhibits lipid accumulation by regulating early adipogenesis and m-TOR signaling. |
| PubMed: | Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress. |
| PubMed: | 5,6,7-trimethoxyflavone suppresses pro-inflammatory mediators in lipopolysaccharide-induced RAW 264.7 macrophages and protects mice from lethal endotoxin shock. |
| PubMed: | Synergistic Action of Flavonoids, Baicalein, and Daidzein in Estrogenic and Neuroprotective Effects: A Development of Potential Health Products and Therapeutic Drugs against Alzheimer's Disease. |
| PubMed: | HPLC and chemometrics for the quality consistency evaluation of Shuanghuanglian injection. |
| PubMed: | Bioconversion of flavones during fermentation in milk containing Scutellaria baicalensis extract by Lactobacillus brevis. |
| PubMed: | Inhibitory effect of skullcap (Scutellaria baicalensis) extract on ovalbumin permeation in vitro and in vivo. |
| PubMed: | Inhibitory effect of baicalin and baicalein on ovarian cancer cells. |
| PubMed: | Identification of flavone glucuronide isomers by metal complexation and tandem mass spectrometry: regioselectivity of uridine 5'-diphosphate-glucuronosyltransferase isozymes in the biotransformation of flavones. |
| PubMed: | Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans : activation of the Nrf2 signaling pathway and prolongation of lifespan. |
| PubMed: | Effects of baicalein on apoptosis, cell cycle arrest, migration and invasion of osteosarcoma cells. |
| PubMed: | Anti-inflammatory effect of Sosihotang via inhibition of nuclear factor-κB and mitogen-activated protein kinases signaling pathways in lipopolysaccharide-stimulated RAW 264.7 macrophage cells. |
| PubMed: | Baicalein protects against 6-OHDA-induced neurotoxicity through activation of Keap1/Nrf2/HO-1 and involving PKCα and PI3K/AKT signaling pathways. |
| PubMed: | The role of intestinal microflora in anti-inflammatory effect of baicalin in mice. |
| PubMed: | Protective effects of baicalein against excess L-DOPA-induced dopamine quinone neurotoxicity. |
| PubMed: | FDA-approved drugs that protect mammalian neurons from glucose toxicity slow aging dependent on cbp and protect against proteotoxicity. |
| PubMed: | Study of the chemical composition and antimicrobial activities of ethanolic extracts from roots of Scutellaria baicalensis Georgi. |
| PubMed: | Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis. |
| PubMed: | Structure-metabolism relationships for the glucuronidation of flavonoids by UGT1A3 and UGT1A9. |
| PubMed: | Thermodynamic versus kinetic control of antioxidant synergism between β-carotene and (iso)flavonoids and their glycosides in liposomes. |
| PubMed: | [Study on optimizing prescription of baicalein long circulating liposomes]. |
| PubMed: | Structure-affinity relationship of flavones on binding to serum albumins: effect of hydroxyl groups on ring A. |
| PubMed: | Dietary flavonoids activate the constitutive androstane receptor (CAR). |
| PubMed: | Glycosylation of dietary flavonoids decreases the affinities for plasma protein. |
| PubMed: | Antihepatotoxic effect of corn peptides against Bacillus Calmette-Guerin/lipopolysaccharide-induced liver injury in mice. |
| PubMed: | Synergistic anti-cancer effect of baicalein and silymarin on human hepatoma HepG2 Cells. |
| PubMed: | Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. |
| PubMed: | Sodium borohydride/chloranil-based assay for quantifying total flavonoids. |
| PubMed: | Baicalein inhibits osteoclast differentiation and induces mature osteoclast apoptosis. |
| PubMed: | Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. |
| PubMed: | Comparison of the major flavonoid content of S. baicalensis, S. lateriflora, and their commercial products. |
| PubMed: | Synthesis and biological evaluation of novel C(6) modified baicalein derivatives as antioxidative agents. |
| PubMed: | Cytoprotective effect of baicalein against peroxynitrite-induced toxicity in LLC-PK(1) cells. |
| PubMed: | [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60]. |
| PubMed: | Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay. |
| PubMed: | Chemopreventive effects of minor dietary constituents in common foods on human cancer cells. |
| PubMed: | Baicalein, a flavonoid extracted from a methanolic extract of Oroxylum indicum inhibits proliferation of a cancer cell line in vitro via induction of apoptosis. |
| PubMed: | Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell death. |
| PubMed: | Baicalein induction of hydroxyl radical formation via 12-lipoxygenase in human platelets: an ESR study. |
| PubMed: | Wogonin suppresses TNF-alpha-induced MMP-9 expression by blocking the NF-kappaB activation via MAPK signaling pathways in human aortic smooth muscle cells. |
| PubMed: | Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis. |
| PubMed: | Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme. |
| PubMed: | Baicalein inhibits adipocyte differentiation by enhancing COX-2 expression. |
| PubMed: | Beneficial effect of flavonoid baicalein in cisplatin-induced cell death of human glioma cells. |
| PubMed: | Ultrasound-assisted extraction methodology as a tool to improve the antioxidant properties of herbal drug Xiao-chia-hu-tang. |
| PubMed: | alpha-Glucosidase inhibition of 6-hydroxyflavones. Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as alpha-glucosidase inhibitors. |
| PubMed: | Importance of the B ring and its substitution on the alpha-glucosidase inhibitory activity of baicalein, 5,6,7-trihydroxyflavone. |
| PubMed: | Potent Inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity. |
| PubMed: | Kinetic study of flavonoid reactions with stable radicals. |
| PubMed: | Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats. |
| PubMed: | Structure-activity relationships for alpha-glucosidase inhibition of baicalein, 5,6,7-trihydroxyflavone: the effect of A-ring substitution. |
| PubMed: | Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. |
| PubMed: | Baicalein induced in vitro apoptosis undergo caspases activity in human promyelocytic leukemia HL-60 cells. |
| PubMed: | Insect antifeedant activity of flavones and chromones against Spodoptera litura. |
| PubMed: | Inhibition of thyroid type 1 deiodinase activity by flavonoids. |
| PubMed: | Effects of scutellariae radix extract and its components (baicalein, baicalin, and wogonin) on the experimental elevation of aqueous flare in pigmented rabbits. |
| PubMed: | Effect of Sho-saiko-to extract on HGF and TGF-beta levels of intraorgans in liver-injured rats after partial hepatectomy. |
| PubMed: | Effects of Sho-saiko-to extract on liver fibrosis in relation to the changes in hydroxyproline and retinoid levels of the liver in rats. |
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