|
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
|
| Soluble in: |
| | water, 120.7 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for casticin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for casticin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
| | 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5315263 |
| Pubchem (sid): | 135116321 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxy- | | 3',5- | dihydroxy-3,4',6,7-tetramethoxyflavone | | 5- | hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,6,7-trimethoxychromen-4-one | | | vitexicarpin |
Articles:
| PubMed: | Molecular Mechanisms of Casticin Action: an Update on its Antitumor Functions. |
| PubMed: | Activation of the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway is involved in the casticin-induced apoptosis of colon cancer cells. |
| PubMed: | Casticin inhibits self-renewal of liver cancer stem cells from the MHCC97 cell line. |
| PubMed: | Casticin induces breast cancer cell apoptosis by inhibiting the expression of forkhead box protein M1. |
| PubMed: | Casticin inhibits epithelial-mesenchymal transition of liver cancer stem cells of the SMMC-7721 cell line through downregulating Twist. |
| PubMed: | Quality evaluation of medicinal products and health foods containing chaste berry (Vitex agnus-castus) in Japanese, European and American markets. |
| PubMed: | The effect of O-methylated flavonoids and other co-metabolites on the crystallization and purification of artemisinin. |
| PubMed: | Casticin suppresses self-renewal and invasion of lung cancer stem-like cells from A549 cells through down-regulation of pAkt. |
| PubMed: | Cytotoxicity of Vitex agnus-castus fruit extract and its major component, casticin, correlates with differentiation status in leukemia cell lines. |
| PubMed: | Involvement of histone H3 phosphorylation through p38 MAPK pathway activation in casticin-induced cytocidal effects against the human promyelocytic cell line HL-60. |
| PubMed: | Low potency homeopathic remedies and allopathic herbal medicines: is there an overlap? |
| PubMed: | [Chemical constituents from ethyl acetate extract of Artemisia rupestris]. |
| PubMed: | Casticin induces human glioma cell death through apoptosis and mitotic arrest. |
| PubMed: | Casticin induces ovarian cancer cell apoptosis by repressing FoxM1 through the activation of FOXO3a. |
| PubMed: | Regiospecific methylation of a dietary flavonoid scaffold selectively enhances IL-1β production following Toll-like receptor 2 stimulation in THP-1 monocytes. |
| PubMed: | Effects of sesquiterpene, flavonoid and coumarin types of compounds from Artemisia annua L. on production of mediators of angiogenesis. |
| PubMed: | Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction. |
| PubMed: | Casticin induces caspase-mediated apoptosis via activation of mitochondrial pathway and upregulation of DR5 in human lung cancer cells. |
| PubMed: | Casticin potentiates TRAIL-induced apoptosis of gastric cancer cells through endoplasmic reticulum stress. |
| PubMed: | Development and validation of a rapid ultra-high performance liquid chromatography diode array detector method for Vitex agnus-castus. |
| PubMed: | Evaluation of pharmacological activities and assessment of intraocular penetration of an ayurvedic polyherbal eye drop (Itone™) in experimental models. |
| PubMed: | Casticin, a flavonoid, potentiates TRAIL-induced apoptosis through modulation of anti-apoptotic proteins and death receptor 5 in colon cancer cells. |
| PubMed: | Casticin induces growth suppression and cell cycle arrest through activation of FOXO3a in hepatocellular carcinoma. |
| PubMed: | Drug screening study using glioma stem-like cells. |
| PubMed: | The flavonoids casticin and artemetin are poorly extracted and are unstable in an Artemisia annua tea infusion. |
| PubMed: | Microarray-based mRNA expression profiling of leukemia cells treated with the flavonoid, casticin. |
| PubMed: | Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase. |
| PubMed: | Metabolism studies of casticin in rats using HPLC-ESI-MS(n). |
| PubMed: | Vitexicarpin induces apoptosis in human prostate carcinoma PC-3 cells through G2/M phase arrest. |
| PubMed: | Quantitative determination and pharmacokinetic study of casticin in rat plasma by liquid chromatography-mass spectrometry. |
| PubMed: | Casticin-induced apoptosis involves death receptor 5 upregulation in hepatocellular carcinoma cells. |
| PubMed: | Mitchellenes A-E, cyclic sesquiterpenes from the Australian plant Eremophila mitchellii. |
| PubMed: | Induction of apoptosis by casticin in cervical cancer cells through reactive oxygen species-mediated mitochondrial signaling pathways. |
| PubMed: | Vascular protective role of vitexicarpin isolated from Vitex rotundifolia in human umbilical vein endothelial cells. |
| PubMed: | [Preparative isolation and purification of the active components from Viticis Fructus by high-speed counter-current chromatography]. |
| PubMed: | Inhibitory effects of casticin on migration of eosinophil and expression of chemokines and adhesion molecules in A549 lung epithelial cells via NF-κB inactivation. |
| PubMed: | Flavonoids inhibit angiogenic cytokine production by human glioma cells. |
| PubMed: | Phytoconstituents from Vitex agnus-castus fruits. |
| PubMed: | Casticin, a flavonoid isolated from Vitex rotundifolia, inhibits prolactin release in vivo and in vitro. |
| PubMed: | Opioidergic mechanisms underlying the actions of Vitex agnus-castus L. |
| PubMed: | [Vitexicarpin affects proliferation and apoptosis in mutated p53 breast cancer cell]. |
| PubMed: | Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. |
| PubMed: | Effects of the flavonoid casticin from Brazilian Croton betulaster in cerebral cortical progenitors in vitro: direct and indirect action through astrocytes. |
| PubMed: | Isolation and immunomodulatory properties of a flavonoid, casticin from Vitex agnus-castus. |
| PubMed: | Antiinflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus. |
| PubMed: | Casticin induces leukemic cell death through apoptosis and mitotic catastrophe. |
| PubMed: | Antiproliferative effect of flavonoids and sesquiterpenoids from Achillea millefolium s.l. on cultured human tumour cell lines. |
| PubMed: | Evaluation of the estrogenic activity of the constituents in the fruits of Vitex rotundifolia L. for the potential treatment of premenstrual syndrome. |
| PubMed: | In vivo effect of casticin on acute inflammation. |
| PubMed: | Isolation of high-purity casticin from Artemisia annua L. by high-speed counter-current chromatography. |
| PubMed: | Anti-nociceptive and anti-hyperprolactinemia activities of Fructus Viticis and its effective fractions and chemical constituents. |
| PubMed: | Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents. |
| PubMed: | Are extraction methods in quantitative assays of pharmacopoeia monographs exhaustive? A comparison with pressurized liquid extraction. |
| PubMed: | The flavonoid Casticin has multiple mechanisms of tumor cytotoxicity action. |
| PubMed: | [Vitexicarpin, a flavonoid from Vitex trifolia L., induces apoptosis in K562 cells via mitochondria-controlled apoptotic pathway]. |
| PubMed: | G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil.). |
| PubMed: | Characteristics, clinical effect profile and tolerability of a nasal spray preparation of Artemisia abrotanum L. for allergic rhinitis. |
| PubMed: | Cytotoxic flavone analogues of vitexicarpin, a constituent of the leaves of Vitex negundo. |
| PubMed: | Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from vitex trifolia. |
| PubMed: | New diterpenes and norditerpenes from the fruits of Vitex rotundifolia. |
| PubMed: | New eudesmane sesquiterpenes from Plectranthus cylindraceus. |
| PubMed: | Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro. |
| PubMed: | [Chemical constituents of the fruits of Vitex trifolia L]. |
| PubMed: | Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones. |
| PubMed: | Isolation and identification of three new flavones from Achillea millefolium L. |
|