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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 476.60 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 416.00 °F. TCC ( 213.40 °C. ) (est)
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| logP (o/w): | 3.270 (est) |
| Soluble in: |
| | water, 11.42 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for 5,7-dimethoxyflavone usage levels up to: | | | not for fragrance use.
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| Recommendation for 5,7-dimethoxyflavone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 5,7-dimethoxy-2-phenyl- | | | chrysin dimethyl ether | | | chrysin dimethylether | | 5,7- | dimethoxy-2-phenyl-4H-chromen-4-one | | 5,7- | dimethoxy-2-phenylchromen-4-one |
Articles:
| PubMed: | Identification and evaluation of anti-inflammatory compounds from Kaempferia parviflora. |
| PubMed: | A 5,7-dimethoxyflavone/hydroxypropyl-β-cyclodextrin inclusion complex with anti-butyrylcholinesterase activity. |
| PubMed: | The O-methylation of chrysin markedly improves its intestinal anti-inflammatory properties: Structure-activity relationships of flavones. |
| PubMed: | Novel formulation strategies for enhancing oral delivery of methoxyflavones in Kaempferia parviflora by SMEDDS or complexation with 2-hydroxypropyl-β-cyclodextrin. |
| PubMed: | Pharmacokinetics, bioavailability, tissue distribution, excretion, and metabolite identification of methoxyflavones in Kaempferia parviflora extract in rats. |
| PubMed: | Isoflavones inhibit the clonogenicity of human colon cancer cells. |
| PubMed: | 5,7-Dimethoxyflavone, an activator of PPARα/γ, inhibits UVB-induced MMP expression in human skin fibroblast cells. |
| PubMed: | Methylated chrysin reduced cell proliferation, but antagonized cytotoxicity of other anticancer drugs in acute lymphoblastic leukemia. |
| PubMed: | Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines. |
| PubMed: | Kaempferia parviflora, a plant used in traditional medicine to enhance sexual performance contains large amounts of low affinity PDE5 inhibitors. |
| PubMed: | A chrysin analog exhibited strong inhibitory activities against both PGE2 and NO production. |
| PubMed: | 5, 7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells. |
| PubMed: | Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model. |
| PubMed: | 5,7-dimethoxyflavone induces melanogenesis in B16F10 melanoma cells through cAMP-dependent signalling. |
| PubMed: | Antiproliferative activity of three methoxylated flavonoids isolated from Zeyheria montana Mart. (Bignoniaceae) leaves. |
| PubMed: | 5,7-Dimethoxyflavone and multiple flavonoids in combination alter the ABCG2-mediated tissue distribution of mitoxantrone in mice. |
| PubMed: | Suppressive effects of methoxyflavonoids isolated from Kaempferia parviflora on inducible nitric oxide synthase (iNOS) expression in RAW 264.7 cells. |
| PubMed: | Possible mechanisms of vasorelaxation for 5,7-dimethoxyflavone from Kaempferia parviflora in the rat aorta. |
| PubMed: | Effects of single and multiple flavonoids on BCRP-mediated accumulation, cytotoxicity and transport of mitoxantrone in vitro. |
| PubMed: | Chemical constituents from tiger's betel, Piper porphyrophyllum N.E.Br. (Fam. Piperaceae). |
| PubMed: | Amino and nitro derivatives of 5,7-dimethoxyflavone from Kaempferia parviflora and cytotoxicity against KB cell line. |
| PubMed: | Structural modification of 5,7-dimethoxyflavone from Kaempferia parviflora and biological activities. |
| PubMed: | Anticholinesterase activity of 7-methoxyflavones isolated from Kaempferia parviflora. |
| PubMed: | New 4'-substituted flavones from the fruit peels of Citrus limon (L.) Burm.f. |
| PubMed: | Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line. |
| PubMed: | Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones. |
| PubMed: | Aromatase inhibition by bioavailable methylated flavones. |
| PubMed: | Benzo[a]pyrene-induced cytochrome P450 1A and DNA binding in cultured trout hepatocytes - inhibition by plant polyphenols. |
| PubMed: | Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components. |
| PubMed: | Simultaneous identification and quantitation of 11 flavonoid constituents in Kaempferia parviflora by gas chromatography. |
| PubMed: | Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones. |
| PubMed: | Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function. |
| PubMed: | Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish. |
| PubMed: | Inhibition of viral proteases by Zingiberaceae extracts and flavones isolated from Kaempferia parviflora. |
| PubMed: | Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. |
| PubMed: | Methylation protects dietary flavonoids from rapid hepatic metabolism. |
| PubMed: | Cytochrome P450 1B1, a novel chemopreventive target for benzo[a]pyrene-initiated human esophageal cancer. |
| PubMed: | Inhibition of benzo[a]pyrene-activating enzymes and DNA binding in human bronchial epithelial BEAS-2B cells by methoxylated flavonoids. |
| PubMed: | Preferential induction of CYP1B1 by benzo[a]pyrene in human oral epithelial cells: impact on DNA adduct formation and prevention by polyphenols. |
| PubMed: | 5,7-Dimethoxyflavone downregulates CYP1A1 expression and benzo[a]pyrene-induced DNA binding in Hep G2 cells. |
| PubMed: | Flavanoids from Caesalpinia pulcherrima. |
| PubMed: | Novel compounds from Piper methysticum Forst (Kava Kava) roots and their effect on cyclooxygenase enzyme. |
| PubMed: | Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities. |
| PubMed: | Flavonoids from Leptospermum scoparium with affinity to the benzodiazepine receptor characterized by structure activity relationships and in vivo studies of a plant extract. |
| PubMed: | Anti-inflammatory activity of 5,7-dimethoxyflavone. |
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