corynanthine
methyl (16beta,17alpha)-17-hydroxyyohimban-16-carboxylate
 
Notes:
None found
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CAS Number: 483-10-3Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 207-590-0
FDA UNII: F5Z7C9RK8U
Nikkaji Web: J5.984F
MDL: MFCD00069659
XlogP3: 2.90 (est)
Molecular Weight: 354.44982000
Formula: C21 H26 N2 O3
BioActivity Summary: listing
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Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 543.00 °C. @ 760.00 mm Hg (est)
Flash Point: 540.00 °F. TCC ( 282.20 °C. ) (est)
logP (o/w): 2.200 (est)
Soluble in:
 water, 401.8 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
ExtraSynthese
For experimental / research use only.
Corynanthine (HPLC) ≥90%
Santa Cruz Biotechnology
For experimental / research use only.
Corynanthine
Sigma-Aldrich: Sigma
For experimental / research use only.
Corynanthine
Silver Fern Chemical
Yohimbine Extract
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for corynanthine usage levels up to:
 not for fragrance use.
 
Recommendation for corynanthine flavor usage levels up to:
 not for flavor use.
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Safety References:
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EPA ACToR: Toxicology Data
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Laboratory Chemical Safety Summary : 92766
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 methyl (1S,15R,18S,19S,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
Chemidplus: 0000483103
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References:
 methyl (1S,15R,18S,19S,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 92766
Pubchem (sid): 135051976
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
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VCF-Online: VCF Volatile Compounds in Food
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Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 found in nature
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Synonyms:
 corynanthin
 methyl (16beta,17alpha)-17-hydroxyyohimban-16-carboxylate
 methyl (1S,15R,18S,19S,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
 rauhimbin
 rauhimbine
 yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16beta,17alpha)- (9CI)
 yohimban-16beta-carboxylic acid, 17alpha-hydroxy-, methyl ester (8CI)
 yohimbine
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Articles:
PubMed: Regulation of Differentiation and Function of Helper T Cells by Lymphocyte-Derived Catecholamines via α1- and β2-Adrenoceptors.
PubMed: Roles of the locus coeruleus and adrenergic receptors in brain-mediated hypothalamic-pituitary-adrenal axis responses to intracerebroventricular alcohol.
PubMed: Chromatographic fingerprint analysis of yohimbe bark and related dietary supplements using UHPLC/UV/MS.
PubMed: Modulation of natural killer cell function by alpha-adrenoreceptor-coupled signalling.
PubMed: Inhibitory effect of galanin on adrenaline- and noradrenaline-induced increased oxytocin secretion in rat neurohypophyseal cell cultures.
PubMed: [Effect of the endogenous catecholamines synthesized by lymphocytes on T cell proliferation].
PubMed: [Studies on predict of absorption of corynanthine, yohimbine, ajmalicine and ajmaline across human intestinal epithelial by using human Caco-2 cells monolayers].
PubMed: Significance of the adrenergic system in the regulation of vasopressin secretion in rat neurohypophyseal tissue cultures.
PubMed: Stimulation of an alpha1-adrenergic receptor downregulates ecto-5' nucleotidase activity on the apical membrane of RPE cells.
PubMed: Presynaptic alpha1 adrenergic receptors differentially regulate synaptic glutamate and GABA release to hypothalamic presympathetic neurons.
PubMed: Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline.
PubMed: Histamine receptors that influence blockage of the normal human nasal airway.
PubMed: Pharmacological characterization of unique prazosin-binding sites in human kidney.
PubMed: Ocular hypotensive effects of melatonin receptor agonists in the rabbit: further evidence for an MT3 receptor.
PubMed: Influence of prazosin and clonidine on morphine analgesia, tolerance and withdrawal in mice.
PubMed: Basolateral adrenoceptor activation mediates noradrenaline-induced Cl- secretion in M-1 mouse cortical collecting duct cells.
PubMed: The effect of adrenergic compounds on neurogenic dural vasodilatation.
PubMed: Leishmanicidal, antiplasmodial and cytotoxic activity of indole alkaloids from Corynanthe pachyceras.
PubMed: Characterisation of the functional alpha-adrenoceptor subtype in the isolated female pig urethra.
PubMed: Reduced noradrenergic tone to the hypothalamic paraventricular nucleus contributes to the stress hyporesponsiveness of lactation.
PubMed: Mechanism of resistance to alpha-adrenergic receptor antagonists of renal nerve stimulation-induced vasoconstriction at low frequencies.
PubMed: Subtype determination of presynaptic alpha 2-autoreceptors in the rabbit pulmonary artery and human saphenous vein.
PubMed: Effects of enflurane on adrenergic function in canine mesenteric artery and vein.
PubMed: Comparison of the interaction of agmatine and crude methanolic extracts of bovine lung and brain with alpha 2-adrenoceptor binding sites.
PubMed: Studies on the protective effect of azepexole on ouabain-induced cardiac arrhythmias and lethality in guinea-pig.
PubMed: Corynanthine inhibits, while idazoxan potentiates, cardiotoxic effects of ouabain.
PubMed: The relationship between density of alpha-adrenoceptor binding sites and contractile responses in several porcine isolated blood vessels.
PubMed: Presynaptic alpha 2A-adrenoceptors inhibit the release of endogenous dopamine in rabbit caudate nucleus slices.
PubMed: Multiple alpha-2 adrenergic receptor subtypes. II. Evidence for a role of rat R alpha-2A adrenergic receptors in the control of nociception, motor behavior and hippocampal synthesis of noradrenaline.
PubMed: Multiple alpha 2 adrenergic receptor subtypes. I. Comparison of [3H]RX821002-labeled rat R alpha-2A adrenergic receptors in cerebral cortex to human H alpha2A adrenergic receptor and other populations of alpha-2 adrenergic subtypes.
PubMed: Molecular properties of the WB4101 enantiomers and of its chiral methyl derivatives for alpha 1-adrenoceptor recognition.
PubMed: Negative inotropic action of corynanthine in the guinea pig papillary muscle is attenuated by glibenclamide.
PubMed: Prevention by specific chemical classes of alpha 1-adrenoceptor antagonists of veratrine-contractures in rat left atria independently of alpha 1-adrenoceptor blockade.
PubMed: Further characterization of human alpha 2-adrenoceptor subtypes: [3H]RX821002 binding and definition of additional selective drugs.
PubMed: Release-inhibiting alpha 2-adrenoceptors at serotonergic axons in rat and rabbit brain cortex: evidence for pharmacological identity with alpha 2-autoreceptors.
PubMed: Infusions of alpha-2 noradrenergic agonists and antagonists into the amygdala: effects on kindling.
PubMed: Cerebral cortex injury: effect of blockers of re-uptake of catecholamines.
PubMed: Presynaptic alpha 2-autoreceptors in brain cortex: alpha 2D in the rat and alpha 2A in the rabbit.
PubMed: Species-selective binding of [3H]-idazoxan to alpha 2-adrenoceptors and non-adrenoceptor, imidazoline binding sites in the central nervous system.
PubMed: Comparison between thermoregulatory effects mediated by alpha 1- and alpha 2-adrenoceptors in normothermic and febrile rabbits.
PubMed: Effect of flutonidine on ouabain-induced arrhythmias and lethality in guinea-pig.
PubMed: Potentiation of dark onset feeding in obese mice (genotype ob/ob) following central injection of norepinephrine and clonidine.
PubMed: Effects of plant flavonoids and other allelochemicals on insect cytochrome P-450 dependent steroid hydroxylase activity.
PubMed: Identification and characterization of the alpha 2D-adrenoceptor subtype in single cells prepared from guinea pig tracheal smooth muscles.
PubMed: "5-HT1R" or 5-HT1D sites? Evidence for 5-HT1D binding sites in rabbit brain.
PubMed: 5-HT1D binding sites in various species: similar pharmacological profile in dog, monkey, calf, guinea-pig and human brain membranes.
PubMed: [3H]-MK 912 binding delineates two alpha 2-adrenoceptor subtypes in rat CNS one of which is identical with the cloned pA2d alpha 2-adrenoceptor.
PubMed: An endothelial 5-HT receptor that mediates relaxation in guinea-pig isolated jugular vein resembles the 5-HT1D subtype.
PubMed: Characterization of prejunctional alpha-2 adrenergic receptors involved in modulation of adrenergic transmitter release in the isolated perfused rat kidney.
PubMed: [Effects of adrenergic drugs injected into the nucleus tractus solitarius region on the baroreceptor reflex in rabbits].
PubMed: Prostaglandin synthesis elicited by adrenergic stimuli is mediated via alpha-2C and alpha-1A adrenergic receptors in cultured smooth muscle cells of rabbit aorta.
PubMed: The effect of some alpha-adrenoceptor antagonists on spontaneous myogenic activity in the rat portal vein and the putative involvement of ATP-sensitive K+ channels.
PubMed: Protective action of clonidine against the arrhythmogenic and lethal effects of ouabain in guinea-pigs.
PubMed: Characterization of prazosin-sensitive alpha 2 B-adrenoceptors expressed by cultured rat IMCD cells.
PubMed: Differential modulation of (+)-amphetamine-induced rotation in unilateral substantia nigra-lesioned rats by alpha 1 as compared to alpha 2 agonists and antagonists.
PubMed: Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound.
PubMed: Effect of antiarrhythmic drugs on the postischaemic metabolic recovery of isolated rat hearts.
PubMed: Sex differences in central adrenoreceptor-mediated vasopressin response to hemorrhage.
PubMed: The role of alpha 1-adrenoceptor subtypes in the phasic and tonic responses to phenylephrine in the longitudinal smooth muscle of the rat portal vein.
PubMed: Biphasic effects of yohimbine on the ejaculatory response in the dog.
PubMed: The effect of alpha blockade on iontophoresis-induced ocular shedding of latent HSV-1 W in different host animals.
PubMed: Serotonergic mediation of spinal analgesia and its interaction with noradrenergic systems.
PubMed: Involvement of alpha-2 adrenergic receptor subtypes in hyperglycemia.
PubMed: Prostaglandin synthesis elicited by adrenergic stimuli in rabbit aorta is mediated via alpha-1 and alpha-2 adrenergic receptors.
PubMed: Pharmacological characterization of the postjunctional alpha-adrenoceptors of the rat isolated seminal vesicle.
PubMed: Alpha 2-adrenoceptor antisecretory responses in the rat jejunum.
PubMed: Antiarrhythmic and antinecrotic effects of yohimbine stereoisomers in rats during coronary occlusion and reperfusion.
PubMed: Organization and actions of the noradrenergic input to the hamster's superior colliculus.
PubMed: 5-Hydroxytryptamine (5-HT)-induced endothelium-dependent relaxation of pig coronary arteries is mediated by 5-HT receptors similar to the 5-HT1D receptor subtype.
PubMed: Unmasking sensitive alpha 2-adrenoceptor-mediated renal vasoconstriction in conscious rats.
PubMed: Noradrenaline enhances temporal auditory contrast and neuronal timing precision in the cochlear nucleus of the mustached bat.
PubMed: Activation of alpha 2-adrenoceptors attenuates the inotropic effect of field stimulation in atria.
PubMed: Potentiation by treatment with reserpine of alpha 2-adrenoceptor-mediated contractions of rat tail artery.
PubMed: Renal periarterial nerve stimulation-induced vasoconstriction at low frequencies is primarily due to release of a purinergic transmitter in the rat.
PubMed: Alpha 2-adrenergic receptors in neuronal and glial cultures: characterization and comparison.
PubMed: M-octopamine injected into the paraventricular nucleus induces eating in rats: a comparison with noradrenaline-induced eating.
PubMed: Evidence for multiple [3H]prazosin binding sites in canine brain membranes.
PubMed: Evidence for alpha 1-adrenoceptor subtype predominance in the rat seminal vesicle.
PubMed: Characterization and regional distribution of alpha 2-adrenoceptors in postmortem human brain using the full agonist [3H]UK 14304.
PubMed: Isomeric yohimbine alkaloids block calcium-activated K+ channels in medullary thick ascending limb cells of rabbit kidney.
PubMed: Localization and characterization of alpha-2 adrenoceptors in the isolated canine pulmonary vein.
PubMed: Acetylcholine and norepinephrine stimulate the release of corticotropin-releasing factor-41 from the rat hypothalamus in vitro.
PubMed: An attempt at selective protection from phenoxybenzamine of postjunctional alpha-adrenoceptor subtypes mediating contractions to noradrenaline in the rabbit isolated saphenous vein.
PubMed: Pharmacological analysis of postjunctional alpha-adrenoceptors mediating contractions to (-)-noradrenaline in the rabbit isolated lateral saphenous vein can be explained by interacting responses to simultaneous activation of alpha 1- and alpha 2-adrenoceptors.
PubMed: An examination of the postjunctional alpha-adrenoceptor subtypes for (-)-noradrenaline in several isolated blood vessels from the rabbit.
PubMed: Alpha 1- and alpha 2-adrenoreceptor antagonists produce opposing mydriatic effects by a central action.
PubMed: A comparison of the actions of noradrenaline and UK-14,304 in the longitudinal smooth muscle of the rat isolated portal vein--no evidence for a population of post-junctional alpha 2-adrenoceptors.
PubMed: Central and peripheral inhibition of exocrine pancreatic secretion by alpha-2 adrenergic agonists in the rat.
PubMed: Evidence that the population of postjunctional-adrenoceptors mediating contraction of smooth muscle in the rabbit isolated ear vein is predominantly alpha 2.
PubMed: [Calcium antagonistic action of corynanthine in isolated guinea pig left atria].
PubMed: Antagonistic effects of alpha-adrenoceptor blocking agents on arrhythmias, enzyme release, and myocardial necrosis in isolated rat hearts with coronary occlusion and reperfusion.
PubMed: Pre- and postsynaptic effects of p-tyramine and p-octopamine in the prostatic portion of the rat vas deferens.
PubMed: Opioid-monoamine interactions in spinal antinociception: evidence for serotonin but not norepinephrine reciprocity.
PubMed: The 5-hydroxytryptamine 5-HT1D receptor subtype is negatively coupled to adenylate cyclase in calf substantia nigra.
PubMed: Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.
PubMed: Characterization of alpha-2 adrenergic receptors in the OK cell, an opossum kidney cell line.
PubMed: Activities of octopamine and synephrine stereoisomers on alpha-adrenoceptors.
PubMed: A two-state model for the 5-HT2 receptor: effects of alpha-adrenoceptor ligands.
PubMed: Electrophysiological evidence for an alpha 2-adrenergic inhibitory control of transmitter release in the rabbit mesenteric artery.
PubMed: Different affinity states of alpha-1 adrenergic receptors defined by agonists and antagonists in bovine aorta plasma membranes.
PubMed: Opposing central autonomic actions of alpha 1- and alpha 2-adrenoceptor antagonists on oculomotor tone.
PubMed: Agonist binding at alpha 2-adrenoceptors of human platelets using 3H-UK-14,304: regulation by Gpp(NH)p and cations.
PubMed: The membrane potential of vascular smooth muscle appears to modulate uptake2 of 3H-isoprenaline.
PubMed: Alpha-2 receptors mediate an endogenous noradrenergic suppression of kindling development.
PubMed: Modulation of postdecapitation convulsions in rats by alpha-adrenergic and 5-hydroxytryptamine1A agents.
PubMed: Comparison of drugs with different selectivity for central alpha 1-and alpha 2-adrenoceptors in animal models of epilepsy.
PubMed: Gastric antisecretory and antiulcer effects of WHR1582A, a compound exerting alpha-2 adrenoceptor agonist activity.
PubMed: Modulation of norepinephrine release through alpha 1- and alpha 2-adrenoceptors in rat isolated kidney.
PubMed: The blood pressure effects of alpha-adrenoceptor antagonists injected in the medullary site of action of clonidine: the nucleus reticularis lateralis.
PubMed: Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes.
PubMed: A comparison of the ability of various alpha-adrenoreceptor agonists to induce EGTA-resistant contractions of rat aorta.
PubMed: Responses of the melanophores of the medaka, Oryzias latipes, to adrenergic drugs: evidence for involvement of alpha 2 adrenergic receptors mediating melanin aggregation.
PubMed: Alpha-1 and alpha-2 adrenoceptor binding in cerebral cortex: competition studies with [3H]prazosin and [3H]idazoxan.
PubMed: The effect of hyperthyroidism and hypothyroidism on alpha 1- and alpha 2-adrenergic responsiveness in rat aortic smooth muscle.
PubMed: Central hypotensive activity of ketanserin in cats.
PubMed: Role of central alpha 2-adrenoceptors on the development of muricidal behavior in olfactory bulbectomized rats: effect of alpha 2-adrenoceptor antagonists.
PubMed: Central adrenergic mechanisms in hemorrhage-induced vasopressin secretion.
PubMed: Are beta- and alpha 2-adrenoceptors co-regulated during their stimulation? Behavioral studies.
PubMed: Possible involvement of presynaptic alpha 1-adrenoceptors in the effects of idazoxan and prazosin on 3H-noradrenaline release from tail arteries of SHR.
PubMed: Effect of cooling on alpha-1 and alpha-2 adrenergic responses in canine saphenous and femoral veins.
PubMed: Postsynaptic alpha-adrenoceptor characterization and Ca2+ channel antagonist and activator actions in rat tail arteries from normotensive and hypertensive animals.
PubMed: Characterization of postsynaptic alpha 1-adrenoceptors in the rabbit iris dilator smooth muscle.
PubMed: Alpha 2-adrenergic receptors on canine platelet membranes characterized by [3H]-yohimbine binding.
PubMed: Characterization of [3H]rauwolscine binding to alpha 2-adrenoceptor sites in the lumbar spinal cord of the cat: comparison to such binding sites in the cat frontal cerebral cortex.
PubMed: Heterogeneity of mammalian alpha 2-adrenoceptors delineated by [3H]yohimbine binding.
PubMed: Central adrenergic control of vasopressin release.
PubMed: Regulation of thyrotropin secretion by the central epinephrine system. Studies in the chronically cannulated rat.
PubMed: Perfusion with calcium free solution potentiates prazosin blockade of noradrenaline induced pressor responses in the mesenteric bed of the rat.
PubMed: Postsynaptic alpha 2-noradrenergic receptors mediate feeding induced by paraventricular nucleus injection of norepinephrine and clonidine.
PubMed: Sub-nanogram analysis of yohimbine and related compounds by high-performance liquid chromatography.
PubMed: Adrenergic modulation of vascular prostacyclin (PGI2) secretion.
PubMed: Pharmacological testing in the laser-induced monkey glaucoma model.
PubMed: Comparison of activity of alpha-adrenoceptor agonists and antagonists in dog and rabbit saphenous vein.
PubMed: The effect of corynanthine on intraocular pressure in clinical trials.
PubMed: Permissive role of spinal alpha 1-adrenoceptors in sudomotor efferents.
PubMed: Characterization of the spinal adrenergic receptors mediating the spinal effects produced by the microinjection of morphine into the periaqueductal gray.
PubMed: Clonidine sensitizes mice for apomorphine-induced stereotypic gnawing: antagonism by neuroleptics and cholecystokinin-like peptides.
PubMed: Endogenous noradrenaline as modulator of hippocampal serotonin (5-HT)-release. Dual effects of yohimbine, rauwolscine and corynanthine as alpha-adrenoceptor antagonists and 5-HT-receptor agonists.
PubMed: Inhibition by yohimbine of the calcium-dependent evoked release of [3H]GABA in rat and mouse brain slices in vitro.
PubMed: Alpha-adrenergic antagonists: correlation of the effect on intraocular pressure and on alpha 2-adrenergic receptor binding specificity in the rabbit eye.
PubMed: Potential changes of frog afferent terminals in response to dopamine.
PubMed: Pharmacological evidence for the involvement of alpha-2 adrenoceptors in the sedative effect of detomidine, a novel sedative-analgesic.
PubMed: Epinephrine- and norepinephrine-evoked potential changes of frog primary afferent terminals: pharmacological characterization of alpha and beta components.
PubMed: Antagonism of N-methyl-D,L-aspartic acid-induced convulsions by antiepileptic drugs and other agents.
PubMed: Evaluation of the alpha 1- and alpha 2-adrenoceptor effects of detomidine, a novel veterinary sedative analgesic.
PubMed: Possible function of alpha 1-adrenoceptors in the CNS in anaesthetized and conscious animals.
PubMed: Clonidine and a beta-agonists induce hyperthermia in rats at high ambient temperature.
PubMed: Characterization of alpha1 adrenergic receptors in human benign prostatic hyperplasia.
PubMed: Pharmacological characterization of alpha adrenoceptors in the rat gastric fundus.
PubMed: Increased affinity and preference of halogenated derivatives of BE 2254 for alpha 1-adrenoceptors demonstrated by functional and binding experiments.
PubMed: Calcium influx-dependent and -independent alpha 1-adrenoceptor-mediated processes of vasoconstriction in vivo do not operate via different alpha 1-adrenoceptor subtypes.
PubMed: Corynanthine and aqueous humor dynamics in rabbits and monkeys.
PubMed: Alpha-adrenoceptor antagonism by apoyohimbine and some observations on the pharmacology of alpha-adrenoceptors in the rat anococcygeus and vas deferens.
PubMed: Spontaneous dorsal root potentials arise from interneuronal activity in the isolated frog spinal cord.
PubMed: Facilitating interaction between rauwolscine and angiotensin in the mesenteric artery of the rabbit.
PubMed: Heterogeneity of smooth muscle alpha adrenoceptors in rat tail artery in vitro.
PubMed: Further study of prerequisites for the enhancement by alpha-adrenoceptor antagonists of the release of noradrenaline.
PubMed: Comparison of the alpha-adrenoceptor antagonist profiles of idazoxan (RX 781094), yohimbine, rauwolscine and corynanthine.
PubMed: The relative contribution of affinity and efficacy to agonist activity: organ selectivity of noradrenaline and oxymetazoline with reference to the classification of drug receptors.
PubMed: Alpha-adrenoreceptor subtypes in blood vessels: physiology and pharmacology.
PubMed: Mechanisms involved in the hyperglycemic response induced by clonidine and other alpha-2 adrenoceptor agonists.
PubMed: Effects of yohimbine stereoisomers on contractions of rat aortic strips produced by agonists with different selectivity for alpha 1- and alpha 2-adrenoceptors.
PubMed: 3H-yohimbine binding to guinea-pig kidney and calf cerebral cortex membranes: comparison with human platelets.
PubMed: Evidence for a physiological role of presynaptic alpha-adrenoceptors: modulation of noradrenaline release in the pithed rabbit.
PubMed: Non-competitive antagonism of the alpha-adrenoceptor-mediated fast component of contraction of rat aorta, by doxazosin and prazosin.
PubMed: Modulation of noradrenaline release in the conscious rabbit through alpha-adrenoceptors.
PubMed: The characteristics of adrenoceptors in homogenates of human cerebral cortex labelled by (3H)-rauwolscine.
PubMed: Effects of yohimbine, rauwolscine and corynanthine on contractions and calcium fluxes induced by depolarization and prostaglandin F2 alpha in rat aorta.
PubMed: Tissue specific susceptibility of alpha-adrenoceptor mediated vasoconstriction to nifedipine.
PubMed: Effects of alpha 1- and alpha 2-adrenoceptor blocking drugs on noradrenaline release rate in anesthetized rabbits.
PubMed: Further functional in vitro comparison of pre- and postsynaptic dopamine receptors in the rabbit caudate nucleus.
PubMed: Effects of alpha-adrenoceptor antagonists on clonidine-induced inhibition of insulin secretion by isolated pancreatic islets.
PubMed: Characterisation of postjunctional alpha-adrenoceptors in isolated human femoral veins and arteries.
PubMed: Different alpha-adrenoceptors modulate the release of 5-hydroxytryptamine and noradrenaline in rat cortex.
PubMed: alpha 2-Adrenoceptor agonists induced mydriasis in the rat by an action within the central nervous system.
PubMed: An electrophysiological study of presynaptic alpha-adrenoceptors in the vas deferens of the mouse.
PubMed: Binding of yohimbine stereoisomers to alpha-adrenoceptors in rat liver and human platelets.
PubMed: Functional postsynaptic alpha 2- but not alpha 1-adrenoceptors in dog saphenous vein exposed to phenoxybenzamine.
PubMed: Characteristics of the [3H]-yohimbine binding on rat brain alpha2-adrenoceptors.
PubMed: alpha-Adrenoceptor blocking properties of raubasine in pithed rats.
PubMed: [3H]Rauwolscine and [3H]yohimbine binding to rat cerebral and human platelet membranes: possible heterogeneity of alpha 2-adrenoceptors.
PubMed: The alpha 1- and alpha 2-adrenoceptor involvement in the central cardiovascular action of clonidine in the conscious renal hypertensive cat.
PubMed: GTP regulates binding of agonists to alpha 2-adrenergic receptors in human platelets.
PubMed: Relative potencies of alpha-1 and alpha-2 antagonists in the locus ceruleus, dorsal raphe and dorsal lateral geniculate nuclei: an electrophysiological study.
PubMed: Cardiovascular effects of GABA, GABA-aminotransferase inhibitors and valproic acid following systemic administration in rats, cats and dogs: pharmacological approach to localize the site of action.
PubMed: Blockade of central alpha 2-adrenoceptors enhances the carotid occlusion response in dogs.
PubMed: alpha-Adrenoceptor-mediated inhibition of noradrenaline release in rabbit brain cortex slices. Receptor properties and role of the biophase concentration of noradrenaline.
PubMed: Pharmacological characterization of the alpha adrenoceptors of the dog basilar artery.
PubMed: Binding characteristics of [3H]guanfacine to rat brain alpha-adrenoceptors. Comparison with [3H]clonidine.
PubMed: Effect of yohimbine and its diastereoisomers on clonidine-induced depression of exploration in the rat.
PubMed: Types and functions of peripheral alpha-adrenoceptors.
PubMed: [125Iodo]BE 2254, a new radioligand for alpha 1-adrenoceptors.
PubMed: Pre- and postsynaptic alpha-adrenoceptor blocking activity of raubasine in the rat vas deferens.
PubMed: Pre- and postsynaptic alpha adrenoceptor selectivity studies with yohimbine and its two diastereoisomers rauwolscine and corynanthine in the anesthetized dog.
PubMed: [125I]BE 2254, a new high affinity radioligand for alpha 1-adrenoceptors.
PubMed: Functional characterization of central alpha-adrenoceptors by yohimbine diastereomers.
PubMed: Characterization of alpha-adrenoceptors participating in the central hypotensive and sedative effects of clonidine using yohimbine, rauwolscine and corynanthine.
PubMed: Stimulation of prostaglandin E2-synthesis by noradrenaline in primary cell cultures from rabbit splenic pulpa is mediated by atypical alpha-adrenoceptors.
PubMed: Yohimbine diastereoisomers: cardiovascular effects after central and peripheral application in the rat.
PubMed: Anxiolytics antagonize yohimbine's discriminative stimulus properties.
PubMed: Complete blockade by phenoxybenzamine of alpha 1- but not of alpha 2-vascular receptors in dogs and the effects of propranolol.
PubMed: Evaluation of the selectivity of alpha-adrenoreceptor blocking drugs for postsynaptic alpha 1- and alpha 2-adrenoreceptors in a simple animal model.
PubMed: Are only alpha 2-adrenergic receptors present in bovine retina?
PubMed: An examination of pre- and postsynaptic alpha-adrenoceptors in the autoperfused rabbit hindlimb.
PubMed: Vasoconstriction mediated by postsynaptic alpha 2-adrenoceptor stimulation.
PubMed: Antagonist/agonist-preferring alpha-adrenoceptors or alpha 1/alpha 2-adrenoceptors?
PubMed: Possible subdivision of postsynaptic alpha-adrenoceptors mediating pressor responses in the pithed rat.
PubMed: Interaction between yohimbine alkaloids and amphetamine in mice.
PubMed: MICROBIAL HYDROXYLATION OF INDOLE ALKALOIDS.
PubMed: [Pharmacological research on the 3, 4, 5-trimethoxybenzoates of yohimbine and corynanthine].
PubMed: [Comparative toxicity of corynanthine and crystallized corynantheine].
PubMed: [Paper partition microchromatography of alkaloids and of various biological nitrogenous bases. III. Examples of the separation of various alkaloids by the acid solvent phase technic (atropine, cocaine, nicotine, sparteine, strychnine and corynanthine families)].
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