cucurbitacin I, 2222-07-3

Articles:

PubMed:	Transcriptional profiling of GBM invasion genes identifies effective inhibitors of the LIM kinase-Cofilin pathway.
PubMed:	N-myc downstream-regulated gene 2 (NDRG2) suppresses the epithelial-mesenchymal transition (EMT) in breast cancer cells via STAT3/Snail signaling.
PubMed:	Downregulation of endogenous STAT3 augments tumoricidal activity of interleukin 15 activated dendritic cell against lymphoma and leukemia via TRAIL.
PubMed:	Nanoprecipitation is more efficient than emulsion solvent evaporation method to encapsulate cucurbitacin I in PLGA nanoparticles.
PubMed:	JSI124 inhibits breast cancer cell growth by suppressing the function of B cells via the downregulation of signal transducer and activator of transcription 3.
PubMed:	Cucurbitacin-I, a natural cell-permeable triterpenoid isolated from Cucurbitaceae, exerts potent anticancer effect in colon cancer.
PubMed:	Antiangiogenic effects of cucurbitacin-I.
PubMed:	Cucurbitacin I induces protective autophagy in glioblastoma in vitro and in vivo.
PubMed:	Dendritic cells loaded with myeloma cells pretreated with a combination of JSI-124 and bortezomib generate potent myeloma-specific cytotoxic T lymphocytes in vitro.
PubMed:	Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling.
PubMed:	Cucurbitacin I blocks cerebrospinal fluid and platelet derived growth factor-BB stimulation of leptomeningeal and meningioma DNA synthesis.
PubMed:	Polyunsaturated fatty acids promote the expansion of myeloid-derived suppressor cells by activating the JAK/STAT3 pathway.
PubMed:	Chrysin overcomes TRAIL resistance of cancer cells through Mcl-1 downregulation by inhibiting STAT3 phosphorylation.
PubMed:	Membrane-bound interleukin-21 and CD137 ligand induce functional human natural killer cells from peripheral blood mononuclear cells through STAT-3 activation.
PubMed:	Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1.
PubMed:	Activation of the NF-κB pathway by the STAT3 inhibitor JSI-124 in human glioblastoma cells.
PubMed:	On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells.
PubMed:	The cucurbitacins E, D and I: investigation of their cytotoxicity toward human chondrosarcoma SW 1353 cell line and their biotransformation in man liver.
PubMed:	Inhibition of the Jak-STAT pathway prevents CNTF-mediated survival of axotomized oxytocinergic magnocellular neurons in organotypic cultures of the rat supraoptic nucleus.
PubMed:	Janus kinase 2 and signal transducer and activator of transcription 3 activation is not essential for CCL3-, CCL5- or CCL8-induced chemotaxis.
PubMed:	Direct regulation of the proglucagon gene by insulin, leptin, and cAMP in embryonic versus adult hypothalamic neurons.
PubMed:	Cucurbitacin induces autophagy through mitochondrial ROS production which counteracts to limit caspase-dependent apoptosis.
PubMed:	Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity.
PubMed:	Targeting signal transducer and activator of transcription 3 pathway by cucurbitacin I diminishes self-renewing and radiochemoresistant abilities in thyroid cancer-derived CD133+ cells.
PubMed:	IL-6 stimulates STAT3 and Pim-1 kinase in pancreatic cancer cell lines.
PubMed:	Inhibition of phosphorylated STAT3 by cucurbitacin I enhances chemoradiosensitivity in medulloblastoma-derived cancer stem cells.
PubMed:	In vitro and in vivo study of cucurbitacins-type triterpene glucoside from Citrullus colocynthis growing in Saudi Arabia against hepatocellular carcinoma.
PubMed:	High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes.
PubMed:	Cucurbitane glucosides from the root of Machilus yaoshansis.
PubMed:	Glioblastoma-induced inhibition of Langerhans cell differentiation from CD34(+) precursors is mediated by IL-6 but unaffected by JAK2/STAT3 inhibition.
PubMed:	Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B leukemic cells.
PubMed:	Cucurbitacin I inhibits tumorigenic ability and enhances radiochemosensitivity in nonsmall cell lung cancer-derived CD133-positive cells.
PubMed:	Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis.
PubMed:	Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics.
PubMed:	Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44(+)ALDH1(+) cells.
PubMed:	STAT3alpha is oncogenic for endometrial carcinoma cells and mediates the oncogenic effects of autocrine human growth hormone.
PubMed:	Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells.
PubMed:	The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo.
PubMed:	Development of a poly(d,l-lactic-co-glycolic acid) nanoparticle formulation of STAT3 inhibitor JSI-124: implication for cancer immunotherapy.
PubMed:	Screening a panel of drugs with diverse mechanisms of action yields potential therapeutic agents against neuroblastoma.
PubMed:	Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells.
PubMed:	Prediction of the solubility of cucurbitacin drugs in self-associating poly(ethylene oxide)-b-poly(alpha-benzyl carboxylate epsilon-caprolactone) block copolymer with different tacticities using molecular dynamics simulation.
PubMed:	Stability of cucurbitacin E in human plasma: chemical hydrolysis and role of plasma esterases.
PubMed:	Roles of nonpolar and polar intermolecular interactions in the improvement of the drug loading capacity of PEO-b-PCL with increasing PCL content for two hydrophobic Cucurbitacin drugs.
PubMed:	Interaction of cucurbitacins with human serum albumin: Thermodynamic characteristics and influence on the binding of site specific ligands.
PubMed:	IL-6-induced activation of MYC is responsible for the down-regulation of CD33 expression in CD33+ myeloma cells.
PubMed:	Quantitative determination of cucurbitacin E and cucurbitacin I in homoeopathic mother tincture of Gratiola officinalis L. by HPLC.
PubMed:	Self-associating poly(ethylene oxide)-b-poly(alpha-cholesteryl carboxylate-epsilon-caprolactone) block copolymer for the solubilization of STAT-3 inhibitor cucurbitacin I.
PubMed:	Curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by STAT-3 signaling.
PubMed:	Development of a STAT3 reporter prostate cancer cell line for high throughput screening of STAT3 activators and inhibitors.
PubMed:	Immunomodulatory and anticancer effects of intra-tumoral co-delivery of synthetic lipid A adjuvant and STAT3 inhibitor, JSI-124.
PubMed:	Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: the role of p53 and p21.
PubMed:	JSI-124 inhibits glioblastoma multiforme cell proliferation through G(2)/M cell cycle arrest and apoptosis augment.
PubMed:	Green tea polyphenol epigallocatechin-3-gallate suppresses collagen production and proliferation in keloid fibroblasts via inhibition of the STAT3-signaling pathway.
PubMed:	Synergistic antitumor effects of CpG oligodeoxynucleotide and STAT3 inhibitory agent JSI-124 in a mouse melanoma tumor model.
PubMed:	Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin.
PubMed:	Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma.
PubMed:	Cucurbitacin I inhibits Stat3 and induces apoptosis in Sézary cells.
PubMed:	STAT3-dependent mouse embryonic stem cell differentiation into cardiomyocytes: analysis of molecular signaling and therapeutic efficacy of cardiomyocyte precommitted mES transplantation in a mouse model of myocardial infarction.
PubMed:	Polymeric micelles for the solubilization and delivery of STAT3 inhibitor cucurbitacins in solid tumors.
PubMed:	Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection.
PubMed:	Two novel glycosidic triterpene alkaloids from the stem barks of Machilus yaoshansis.
PubMed:	Effect of cucurbitacins on bilirubin-albumin binding in human plasma.
PubMed:	Development of a sensitive and specific liquid chromatography/mass spectrometry method for the quantification of cucurbitacin I (JSI-124) in rat plasma.
PubMed:	JSI-124 (cucurbitacin I) inhibits Janus kinase-3/signal transducer and activator of transcription-3 signalling, downregulates nucleophosmin-anaplastic lymphoma kinase (ALK), and induces apoptosis in ALK-positive anaplastic large cell lymphoma cells.
PubMed:	P2 purinergic receptors signal to STAT3 in astrocytes: Difference in STAT3 responses to P2Y and P2X receptor activation.
PubMed:	Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products.
PubMed:	STAT3-independent inhibition of lysophosphatidic acid-mediated upregulation of connective tissue growth factor (CTGF) by cucurbitacin I.
PubMed:	Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration.
PubMed:	[Relationships of Aulacophora beetles feeding behavior with cucurbitacin types in host crops].
PubMed:	Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway.
PubMed:	Targeting Stat3 in cancer therapy.
PubMed:	Cytotoxic and anti-HIV principles from the rhizomes of Begonia nantoensis.
PubMed:	Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.
PubMed:	Effect of cucurbitacins on mRNA coding for laccase in Botrytis cinerea.
PubMed:	Oviposition stimulants and deterrents regulating differential acceptance ofIberis amara byPieris rapae andP. napi oleracea.
PubMed:	A new cucurbitacin profile forCucurbita andreana: A candidate for cucurbitacin tissue culture.
PubMed:	Inhibition of the biosynthesis of deoxyribonucleic acid, ribonucleic acid and protein in HeLa S3 cells by cucurbitacins, glucocorticoid-like cytotoxic triterpenes.
PubMed:	[Poisoning with a kind of Bitter Edible Gourd].
PubMed:	Binding of the cytotoxic and antitumor triterpenes, cucurbitacins, to glucocorticoid receptors of HeLa cells.