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Category: pharmaceuticals / chemical synthisis
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 512.80 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 394.00 °F. TCC ( 201.20 °C. ) (est)
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| logP (o/w): | 2.540 (est) |
| Soluble in: |
| | water, 568.4 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD > 1000 mg/kg Farmaco, Edizione Scientifica. Vol. 38, Pg. 67, 1983.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | pharmaceuticals / chemical synthisis |
| Recommendation for 4',7-dihydroxyflavone usage levels up to: | | | not for fragrance use.
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| Recommendation for 4',7-dihydroxyflavone flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 7-hydroxy-2-(4-hydroxyphenyl)- | | 7,4'- | dihydroxyflavanone | | 7,4'- | dihydroxyflavone | | | flavone, 4',7-dihydroxy- | | 7- | hydroxy-2-(4-hydroxyphenyl)chromen-4-one |
Articles:
| PubMed: | Inducible De Novo Biosynthesis of Isoflavonoids in Soybean Leaves by Spodoptera litura Derived Elicitors: Tracer Techniques Aided by High Resolution LCMS. |
| PubMed: | Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron. |
| PubMed: | The Flavonoid 7,4'-Dihydroxyflavone Inhibits MUC5AC Gene Expression, Production, and Secretion via Regulation of NF-κB, STAT6, and HDAC2. |
| PubMed: | Inhibitory constituents of Sophora tonkinensis on nitric oxide production in RAW 264.7 macrophages. |
| PubMed: | Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMI™, inhibit memory Th2 responses in vitro and in vivo. |
| PubMed: | Synthesis, biological evaluation of 5-carbomethoxymethyl-7-hydroxy-2-pentylchromone, 5-carboethoxymethyl-4',7-dihydroxyflavone and their analogues. |
| PubMed: | Carboxymethyl flavonoids and a monoterpene glucoside from Selaginella moellendorffii. |
| PubMed: | Bioactive flavones and biflavones from Selaginella moellendorffii Hieron. |
| PubMed: | Intestinal first-pass glucuronidation activities of selected dihydroxyflavones. |
| PubMed: | Isolation and characterization of phenolic compounds from the leaves of Salix matsudana. |
| PubMed: | Flavones and flavonols play distinct critical roles during nodulation of Medicago truncatula by Sinorhizobium meliloti. |
| PubMed: | Microbial metabolism. Part 6. Metabolites of 3- and 7-hydroxyflavones. |
| PubMed: | Flavonoids of Crotalaria sessiliflora. |
| PubMed: | Flavonoid-related regulation of auxin accumulation in Agrobacterium tumefaciens-induced plant tumors. |
| PubMed: | New Rhizobium leguminosarum flavonoid-induced proteins revealed by proteome analysis of differentially displayed proteins. |
| PubMed: | [Flavone constituents in the seeds of Sophora vicii folia Hance]. |
| PubMed: | [Chemical components of decoction of radix Paeoniae and radix Glycyrrhizae]. |
| PubMed: | [Constituents of the petroleum ether and ethyl acetate extract fractions from Dracaena cochinensis (Lour.) S.C. Chen]. |
| PubMed: | Structurally diverse chitolipooligosaccharide nod factors accumulate primarily in membranes of wild type Rhizobium leguminosarum biovar trifolii. |
| PubMed: | Flavone-enhanced accumulation and symbiosis-related biological activity of a diglycosyl diacylglycerol membrane glycolipid from Rhizobium leguminosarum biovar trifolii. |
| PubMed: | Phospholipid and fatty acid compositions of Rhizobium leguminosarum biovar trifolii ANU843 in relation to flavone-activated pSym nod gene expression. |
| PubMed: | Chemotaxis of Rhizobium meliloti towards Nodulation Gene-Inducing Compounds from Alfalfa Roots. |
| PubMed: | Flavonoids released naturally from alfalfa promote development of symbiotic glomus spores in vitro. |
| PubMed: | Concurrent Synthesis and Release of nod-Gene-Inducing Flavonoids from Alfalfa Roots. |
| PubMed: | Chrysoeriol and Luteolin Released from Alfalfa Seeds Induce nod Genes in Rhizobium meliloti. |
| PubMed: | [HPLC analysis of flavonoids in the root of six Glycyrrhiza species]. |
| PubMed: | A Chalcone and Two Related Flavonoids Released from Alfalfa Roots Induce nod Genes of Rhizobium meliloti. |
| PubMed: | Interactions among Flavonoid nod Gene Inducers Released from Alfalfa Seeds and Roots. |
| PubMed: | Metabolism of apigenin and related compounds in the rat. Metabolite formation in vivo and by the intestinal microflora in vitro. |
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