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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 587.00 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 421.00 °F. TCC ( 216.00 °C. ) (est)
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| logP (o/w): | 2.960 (est) |
| Soluble in: |
| | water, 45.53 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for eupatorin usage levels up to: | | | not for fragrance use.
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| Recommendation for eupatorin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 97214 |
| Pubchem (sid): | 135052815 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxy- (9CI) | | 3',5- | dihydroxy-4',6,7-trimethoxyflavone | | 5,3'- | dihydroxy-6,7,4'-trimethoxyflavone | | | eupatorine | | | flavone, 3',5-dihydroxy-4',6,7-trimethoxy- (8CI) | | 5- | hydroxy-2-(3-hydroxy-4-methoxyphenyl)-6,7-dimethoxychromen-4-one |
Articles:
| PubMed: | Eupatorin-induced cell death in human leukemia cells is dependent on caspases and activates the mitogen-activated protein kinase pathway. |
| PubMed: | Orthosiphon stamineus protects Caenorhabditis elegans against Staphylococcus aureus infection through immunomodulation. |
| PubMed: | Preparation and characterization of nano liposomes of Orthosiphon stamineus ethanolic extract in soybean phospholipids. |
| PubMed: | Antioxidant and enzyme inhibitory activities of Plebeian herba (Salvia plebeia R. Br.) under different cultivation conditions. |
| PubMed: | Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism. |
| PubMed: | Characterization of the Interaction between Eupatorin and Bovine Serum Albumin by Spectroscopic and Molecular Modeling Methods. |
| PubMed: | A simple isocratic HPLC method for the simultaneous determination of sinensetin, eupatorin, and 3'-hydroxy-5,6,7,4'-tetramethoxyflavone in Orthosiphon stamineus extracts. |
| PubMed: | Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves. |
| PubMed: | Bioactivity-guided isolation of antiproliferative compounds from Centaurea jacea L. |
| PubMed: | Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation. |
| PubMed: | The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis. |
| PubMed: | Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. |
| PubMed: | In vitro effects of active constituents and extracts of Orthosiphon stamineus on the activities of three major human cDNA-expressed cytochrome P450 enzymes. |
| PubMed: | Flavones and rosmarinic acid from Salvia limbata. |
| PubMed: | In vitro modulatory effects of Andrographis paniculata, Centella asiatica and Orthosiphon stamineus on cytochrome P450 2C19 (CYP2C19). |
| PubMed: | Evaluation of the genotoxicity of Orthosiphon stamineus aqueous extract. |
| PubMed: | Bioactivity-guided isolation of antiproliferative compounds from Centaurea arenaria. |
| PubMed: | HPLC and anti-inflammatory studies of the flavonoid rich chloroform extract fraction of Orthosiphon stamineus leaves. |
| PubMed: | The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells. |
| PubMed: | Evaluation of the anti-pyretic potential of Orthosiphon stamineus Benth standardized extract. |
| PubMed: | Antiproliferative and cytostatic effects of the natural product eupatorin on MDA-MB-468 human breast cancer cells due to CYP1-mediated metabolism. |
| PubMed: | Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents. |
| PubMed: | New Bisabolane-Type Sesquiterpenes from the Aerial Parts of Lippia dulcis. |
| PubMed: | Determination of flavonoids from Orthosiphon stamineus in plasma using a simple HPLC method with ultraviolet detection. |
| PubMed: | Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. |
| PubMed: | Constituents of the Vietnamese medicinal plant Orthosiphon stamineus. |
| PubMed: | Analysis of vervain flavonoids by HPLC/Diode array detector method. Its application to quality control. |
| PubMed: | Anti-inflammatory effects of South American Tanacetum vulgare. |
| PubMed: | Lipophilic flavonoids from Orthosiphon spicatus prevent oxidative inactivation of 15-lipoxygenase. |
| PubMed: | Inhibition of mitochondrial respiration and cyanide-stimulated generation of reactive oxygen species by selected flavonoids. |
| PubMed: | Methylated Flavones from Teucrium polium. |
| PubMed: | Plant anticancer agents. IX. Constituents of Hyptis tomentosa. |
| PubMed: | Eupatorin, a constituent of Merrillia caloxylon. |
| PubMed: | Flavonoid constituents from Eupatorium altissimum L. (Compositae). |
| PubMed: | Tumor inhibitors. 8. Eupatorin, new cytotoxic flavone from Eupatorium semiserratum. |
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