fraxin
fraxetin-8-O-glucoside
 
Notes:
found in fraxinus excelsior leaves.
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      Product(s):
      524-30-1 Fraxin >98%
      Fraxin and Fraxin-related chemicals protect HUVECs from oxidative stress. anti-inflammatory
       
       
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CAS Number: 524-30-1Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg: 208-355-5
FDA UNII: V7M270Y072
Nikkaji Web: J22.598C
MDL: MFCD00010093
XlogP3-AA: -0.60 (est)
Molecular Weight: 370.31146000
Formula: C16 H18 O10
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: natural substances and extractives
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 722.20 °C. @ 760.00 mm Hg (est)
Flash Point: 513.00 °F. TCC ( 267.10 °C. ) (est)
logP (o/w): -1.930 (est)
Soluble in:
 water, 1.912e+005 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
Alfa Biotechnology
For experimental / research use only.
Fraxin 98%
BOC Sciences
For experimental / research use only.
Fraxin >98%
Odor: characteristic
Use: Fraxin and Fraxin-related chemicals protect HUVECs from oxidative stress. anti-inflammatory
ExtraSynthese
For experimental / research use only.
Fraxin (HPLC) ≥99%
Santa Cruz Biotechnology
For experimental / research use only.
Fraxin
Sigma-Aldrich
For experimental / research use only.
Fraxin
analytical standard
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Safety Information:
Preferred SDS: View
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for fraxin usage levels up to:
 not for fragrance use.
 
Recommendation for fraxin flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 5273568
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 7-hydroxy-6-methoxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
Chemidplus: 0000524301
RTECS: DJ3091000 for cas# 524-30-1
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References:
 7-hydroxy-6-methoxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 5273568
Pubchem (sid): 135227410
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 fraxinus excelsior leaf
Search Trop  Picture
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Synonyms:
2H-1-benzopyran-2-one, 8-(beta-D-glucopyranosyloxy)-7-hydroxy-6-methoxy-
 fraxetin-8-O-glucoside
8-(beta-D-glucopyranosyloxy)-7-hydroxy-6-methoxy-2h-1-benzopyran-2-one
7-hydroxy-6-methoxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one
 paviin
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Articles:
PubMed: Simultaneous Determination of Five Constituents in Qinpijiegu Capsule by High-Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry.
PubMed: Purification of Coumarin Compounds From Cortex fraxinus by Adsorption Chromatography.
PubMed: [Quantitative method for simultaneous assay of four coumarins with one marker in Fraxini Cortex].
PubMed: Antioxidative and anti-inflammatory effects of phenolic compounds from the roots of Ulmus macrocarpa.
PubMed: Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm.
PubMed: Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice.
PubMed: Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells.
PubMed: A new phenolic compound, 4-dehydrochebulic acid-1,6-dimethyl ester from Sapium insigne leaves.
PubMed: [Studies on chemical constituents from stem barks of Fraxinus paxiana].
PubMed: [Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity].
PubMed: Functional analysis of LjSUT4, a vacuolar sucrose transporter from Lotus japonicus.
PubMed: Simultaneous analysis of coumarins and secoiridoids in Cortex Fraxini by high-performance liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry.
PubMed: Cytotoxic phenolic constituents of Acer tegmentosum maxim.
PubMed: Arabidopsis sucrose transporter AtSUC9. High-affinity transport activity, intragenic control of expression, and early flowering mutant phenotype.
PubMed: Metabolic fate of fraxin administered orally to rats.
PubMed: Solution to spectroscopy challenge 10.
PubMed: Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress.
PubMed: A new compound from Rhododendren anthopogonosides maxim.
PubMed: Analysis and bioactive evaluation of the compounds absorbed into blood after oral administration of the extracts of Vaccinium vitis-idaea in rat.
PubMed: Isolation and purification of coumarin compounds from Cortex fraxinus by high-speed counter-current chromatography.
PubMed: Non-aqueous capillary electrophoresis for separation and simultaneous determination of fraxin, esculin and esculetin in Cortex fraxini and its medicinal preparations.
PubMed: HIV gp41 binding phenolic components from Fraxinus sieboldiana var. angustata.
PubMed: Effect of organic cosolvents on the stability and activity of the beta-1,4-galactosyltransferase from bovine colostrum.
PubMed: Structure-activity relationship of coumarins in xanthine oxidase inhibition.
PubMed: Effect of some hydroxycoumarins on complement-mediated hemolysis in human serum.
PubMed: Reversed-phase HPTLC densitometric evaluation of fraxin in Fraxinus excelsior leaves.
PubMed: Role of sulfate concentration in dechlorination of 3,4,5-trichlorocatechol by stable enrichment cultures grown with coumarin and flavanone glycones and aglycones.
PubMed: Semisynthetic transformations of fraxin to biological active compounds.
PubMed: Fast atom bombardment and tandem mass spectrometry for structure determination of steroid and flavonoid glycosides.
PubMed: Inhibition of the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid from arachidonic acid in polymorphonuclear leukocytes by various coumarins.
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