|
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 722.20 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 513.00 °F. TCC ( 267.10 °C. ) (est)
|
| logP (o/w): | -1.930 (est) |
| Soluble in: |
| | water, 1.912e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for fraxin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for fraxin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| EPI System: | View |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5273568 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | 7-hydroxy-6-methoxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one |
| Chemidplus: | 0000524301 |
| RTECS: | DJ3091000 for cas# 524-30-1 |
References:
| | 7-hydroxy-6-methoxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5273568 |
| Pubchem (sid): | 135227410 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 2H-1- | benzopyran-2-one, 8-(beta-D-glucopyranosyloxy)-7-hydroxy-6-methoxy- | | | fraxetin-8-O-glucoside | | 8-(beta-D- | glucopyranosyloxy)-7-hydroxy-6-methoxy-2h-1-benzopyran-2-one | | 7- | hydroxy-6-methoxy-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one | | | paviin |
Articles:
| PubMed: | Simultaneous Determination of Five Constituents in Qinpijiegu Capsule by High-Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry. |
| PubMed: | Purification of Coumarin Compounds From Cortex fraxinus by Adsorption Chromatography. |
| PubMed: | [Quantitative method for simultaneous assay of four coumarins with one marker in Fraxini Cortex]. |
| PubMed: | Antioxidative and anti-inflammatory effects of phenolic compounds from the roots of Ulmus macrocarpa. |
| PubMed: | Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm. |
| PubMed: | Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice. |
| PubMed: | Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells. |
| PubMed: | A new phenolic compound, 4-dehydrochebulic acid-1,6-dimethyl ester from Sapium insigne leaves. |
| PubMed: | [Studies on chemical constituents from stem barks of Fraxinus paxiana]. |
| PubMed: | [Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity]. |
| PubMed: | Functional analysis of LjSUT4, a vacuolar sucrose transporter from Lotus japonicus. |
| PubMed: | Simultaneous analysis of coumarins and secoiridoids in Cortex Fraxini by high-performance liquid chromatography-diode array detection-electrospray ionization tandem mass spectrometry. |
| PubMed: | Cytotoxic phenolic constituents of Acer tegmentosum maxim. |
| PubMed: | Arabidopsis sucrose transporter AtSUC9. High-affinity transport activity, intragenic control of expression, and early flowering mutant phenotype. |
| PubMed: | Metabolic fate of fraxin administered orally to rats. |
| PubMed: | Solution to spectroscopy challenge 10. |
| PubMed: | Natural compounds,fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. |
| PubMed: | A new compound from Rhododendren anthopogonosides maxim. |
| PubMed: | Analysis and bioactive evaluation of the compounds absorbed into blood after oral administration of the extracts of Vaccinium vitis-idaea in rat. |
| PubMed: | Isolation and purification of coumarin compounds from Cortex fraxinus by high-speed counter-current chromatography. |
| PubMed: | Non-aqueous capillary electrophoresis for separation and simultaneous determination of fraxin, esculin and esculetin in Cortex fraxini and its medicinal preparations. |
| PubMed: | HIV gp41 binding phenolic components from Fraxinus sieboldiana var. angustata. |
| PubMed: | Effect of organic cosolvents on the stability and activity of the beta-1,4-galactosyltransferase from bovine colostrum. |
| PubMed: | Structure-activity relationship of coumarins in xanthine oxidase inhibition. |
| PubMed: | Effect of some hydroxycoumarins on complement-mediated hemolysis in human serum. |
| PubMed: | Reversed-phase HPTLC densitometric evaluation of fraxin in Fraxinus excelsior leaves. |
| PubMed: | Role of sulfate concentration in dechlorination of 3,4,5-trichlorocatechol by stable enrichment cultures grown with coumarin and flavanone glycones and aglycones. |
| PubMed: | Semisynthetic transformations of fraxin to biological active compounds. |
| PubMed: | Fast atom bombardment and tandem mass spectrometry for structure determination of steroid and flavonoid glycosides. |
| PubMed: | Inhibition of the formation of 5-hydroxy-6,8,11,14-eicosatetraenoic acid from arachidonic acid in polymorphonuclear leukocytes by various coumarins. |
|