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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 760.40 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 524.00 °F. TCC ( 273.60 °C. ) (est)
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| logP (o/w): | -0.680 (est) |
| Soluble in: |
| | water, 1.838e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for ginkgolide J usage levels up to: | | | not for fragrance use.
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| Recommendation for ginkgolide J flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | ginkgolide A, 7-hydroxy-, (7beta)- | | 7beta- | hydroxyginkgolide A |
Articles:
| PubMed: | Transport of ginkgolides with different lipophilicities based on an hCMEC/D3 cell monolayer as a blood-brain barrier cell model. |
| PubMed: | Urinary excretion of ginkgolide terpene lactones following acute consumption of Ginkgo biloba extract. |
| PubMed: | Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor. |
| PubMed: | Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba. |
| PubMed: | Selective agonism of human pregnane X receptor by individual ginkgolides. |
| PubMed: | Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: functional analysis of the SV23, SV24, and SV25 splice variants. |
| PubMed: | Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides. |
| PubMed: | Development of an alternative method for determination of terpene lactones in ginkgo dry extract. |
| PubMed: | Optimization of extraction technique and validation of developed RP-HPLC-ELSD method for determination of terpene trilactones in Ginkgo biloba leaves. |
| PubMed: | Column liquid chromatography/electrospray ionization-time of flight-mass spectrometry and ultraperformance column liquid chromatography/mass spectrometry methods for the determination of ginkgolides and bilobalide in the leaves of Ginkgo biloba and dietary supplements. |
| PubMed: | Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotype. |
| PubMed: | Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J. |
| PubMed: | Single-laboratory validation for the determination of terpene lactones in Ginkgo biloba dietary supplement crude materials and finished products by high-performance liquid chromatography with evaporative light-scattering detection. |
| PubMed: | Ginkgolide A contributes to the potentiation of acetaminophen toxicity by Ginkgo biloba extract in primary cultures of rat hepatocytes. |
| PubMed: | Ginkgo biloba leaf extract reverses amyloid beta-peptide-induced isoprostane production in rat brain in vitro. |
| PubMed: | Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes. |
| PubMed: | Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts. |
| PubMed: | A method for extraction and quantification of Ginkgo terpene trilactones. |
| PubMed: | Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. |
| PubMed: | Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. |
| PubMed: | Rapid analysis of terpene lactones in extract of Ginkgo biloba L. by high performance liquid chromatography. |
| PubMed: | Simultaneous determination of terpene lactones and flavonoid aglycones in Ginkgo biloba by high-performance liquid chromatography with evaporative light scattering detection. |
| PubMed: | Ginkgolides: selective acetylations, translactonization, and biological evaluation. |
| PubMed: | Liquid chromatography-atmospheric pressure chemical ionisation/mass spectrometry: a rapid and selective method for the quantitative determination of ginkgolides and bilobalide in ginkgo leaf extracts and phytopharmaceuticals. |
| PubMed: | Three ginkgolide hydrates from Ginkgo biloba L.: ginkgolide A monohydrate, ginkgolide C sesquihydrate and ginkgolide J dihydrate, all determined at 120 K. |
| PubMed: | Inhibition of serum deprivation- and staurosporine-induced neuronal apoptosis by Ginkgo biloba extract and some of its constituents. |
| PubMed: | Antioxidative activity of ginkgolides against superoxide in an aprotic environment. |
| PubMed: | Effect of ischaemia and role of eicosanoids in release of atrial natriuretic factor from rat heart. |
| PubMed: | Separate induction of human blood platelet aggregation or cytotoxicity by different concentrations of PAF-acether and thrombin. |
| PubMed: | Effects of PAF antagonists on renal vascular escape and tachyphylaxis in perfused rabbit kidney. |
| PubMed: | The effect of the platelet-activating factor antagonist, BN 52021, on human natural killer cell-mediated cytotoxicity. |
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