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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 1145.90 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 1196.00 °F. TCC ( 646.80 °C. ) (est)
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| logP (o/w): | 2.900 (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 1110 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.
intravenous-mouse LD50 243 mg/kg Saengyak Hakhoechi. Journal of the Society of Pharmacognosy. Vol. 10, Pg. 61, 1979.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for ginsenoside Rb1 usage levels up to: | | | not for fragrance use.
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| Recommendation for ginsenoside Rb1 flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | arasaponin E1 | | pseudo | ginsenoside D | | | ginsenoside RB1 | | beta-D- | glucopyranoside, (3-beta,12-beta)-20-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl- | | 2-O-beta- | glucopyranosyl-(3beta,12beta)-20-((6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl-beta-d-glucopyranoside | | | gynosaponin C | | | gypenoside III | | | panax saponin E | | | sanchinoside E1 |
Articles:
| PubMed: | Red Ginseng Extract Promotes the Hair Growth in Cultured Human Hair Follicles. |
| PubMed: | Ginsenoside Rb1 Prevents H2O2-Induced HUVEC Senescence by Stimulating Sirtuin-1 Pathway. |
| PubMed: | The ginsenoside 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol induces autophagy and apoptosis in human melanoma via AMPK/JNK phosphorylation. |
| PubMed: | Ginsenoside Rb1 eliminates HIV-1 (D3)-transduced cytoprotective human macrophages by inhibiting the AKT pathway. |
| PubMed: | A well-refined in vitro model derived from human embryonic stem cell for screening phytochemicals with midbrain dopaminergic differentiation-boosting potential for improving Parkinson's disease. |
| PubMed: | Ginsenoside Rb1 improves energy metabolism in the skeletal muscle of an animal model of postoperative fatigue syndrome. |
| PubMed: | Expression of antiviral cytokines in Crandell-Reese feline kidney cells pretreated with Korean red ginseng extract or ginsenosides. |
| PubMed: | Protective effects of ginsenoside Rb1 on septic rats and its mechanism. |
| PubMed: | [Major hypoglycemic ingredients of panax notoginseng saponins for treating diabetes]. |
| PubMed: | Subacute oral toxicity study of korean red ginseng extract in sprague-dawley rats. |
| PubMed: | Evaluation of glucosidases of Aspergillus niger strain comparing with other glucosidases in transformation of ginsenoside Rb1 to ginsenosides Rg3. |
| PubMed: | Characterization of a ginsenoside-transforming β-glucosidase from Paenibacillus mucilaginosus and its application for enhanced production of minor ginsenoside F₂. |
| PubMed: | Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters. |
| PubMed: | Ginsenoside rb1 modulates level of monoamine neurotransmitters in mice frontal cortex and cerebellum in response to immobilization stress. |
| PubMed: | Red ginseng protects against gentamicin-induced balance dysfunction and hearing loss in rats through antiapoptotic functions of ginsenoside Rb1. |
| PubMed: | Reduction of hepatitis A virus on FRhK-4 cells treated with Korean red ginseng extract and ginsenosides. |
| PubMed: | Ginseng panaxoside Rb1 reduces body weight in diet-induced obese mice. |
| PubMed: | Microbial transformation of ginsenoside Rb1 to compound K by Lactobacillus paralimentarius. |
| PubMed: | Lactobacillus ginsenosidimutans sp. nov., isolated from kimchi with the ability to transform ginsenosides. |
| PubMed: | Ginsenosides Rb₁ and Rd regulate proliferation of mature keratinocytes through induction of p63 expression in hair follicles. |
| PubMed: | Ginsenoside Re ameliorates inflammation by inhibiting the binding of lipopolysaccharide to TLR4 on macrophages. |
| PubMed: | Highly selective microbial transformation of major ginsenoside Rb1 to gypenoside LXXV by Esteya vermicola CNU120806. |
| PubMed: | Enzymatic biotransformation of ginsenoside Rb1 to compound K by recombinant β-glucosidase from Microbacterium esteraromaticum. |
| PubMed: | Ginsenoside Rb1 inhibits osteoclastogenesis by modulating NF-κB and MAPKs pathways. |
| PubMed: | Ginsenoside Rb1 inhibits cell activation and liver fibrosis in rat hepatic stellate cells. |
| PubMed: | Porosity changes and retention of ginsenosides in North American ginseng root using different dehydration processes. |
| PubMed: | Ginsenoside Rb1 inhibits proliferation and inflammatory responses in rat aortic smooth muscle cells. |
| PubMed: | Ginsenoside Rb1 improves spatial learning and memory by regulation of cell genesis in the hippocampal subregions of rats. |
| PubMed: | Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. |
| PubMed: | Application of gamma irradiation in ginseng for both photodegradation of pesticide pentachloronitrobenzene and microbial decontamination. |
| PubMed: | Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. |
| PubMed: | Effects of extrusion process variables on extractable ginsenosides in wheat-ginseng extrudates. |
| PubMed: | Ginsenosides Rb1 and Rg1 suppress triglyceride accumulation in 3T3-L1 adipocytes and enhance beta-cell insulin secretion and viability in Min6 cells via PKA-dependent pathways. |
| PubMed: | Optimization of lipase-catalyzed synthesis of ginsenoside Rb1 esters using response surface methodology. |
| PubMed: | Optimization of ginsenosides hydrolyzing beta-glucosidase production from Aspergillus niger using response surface methodology. |
| PubMed: | Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. |
| PubMed: | Eastern blotting and immunoaffinity concentration using monoclonal antibody for ginseng saponins in the field of traditional chinese medicines. |
| PubMed: | Effects of population, age, and cultivation methods on ginsenoside content of wild American ginseng (Panax quinquefolium). |
| PubMed: | Transformation of ginsenosides Rb1 and Re from Panax ginseng by food microorganisms. |
| PubMed: | Determination of ginsenosides Rb1, Rc, and Re in different dosage forms of ginseng by negative ion electrospray liquid chromatography-mass spectrometry. |
| PubMed: | Isolation of dammarane saponins from Panax notoginseng by high-speed counter-current chromatography. |
| PubMed: | Modulation of lipopolysaccharide-induced proinflammatory cytokine production in vitro and in vivo by the herbal constituents apigenin (chamomile), ginsenoside Rb(1) (ginseng) and parthenolide (feverfew). |
| PubMed: | [Study on the nootropic mechanism of ginsenoside Rb1 and Rg1--influence on mouse brain development]. |
| PubMed: | [Ginsenoside-Rb1 as a suppressor in central modulation of feeding in the rat]. |
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