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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 1117.10 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 1165.00 °F. TCC ( 629.40 °C. ) (est)
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| logP (o/w): | 4.730 (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 305 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for ginsenoside Rb2 usage levels up to: | | | not for fragrance use.
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| Recommendation for ginsenoside Rb2 flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 20-((6-O-alpha-L- | arabinopyranosyl-beta-D-glucopyranosyl)oxy)-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside | | | cinsenoside C | | | ginsenoside RB2 | | beta-D- | glucopyranoside, (3-beta,12-beta)-20-((6-o-alpha-l-arabinopyranosyl-beta-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-o-beta-d-glucopyranosyl- |
Articles:
| PubMed: | Inhibitory effects of ginsenoside-rb2 on nicotinic stimulation-evoked catecholamine secretion. |
| PubMed: | Ginsenoside-Rb2 inhibits dexamethasone-induced apoptosis through promotion of GPR120 induction in bone marrow-derived mesenchymal stem cells. |
| PubMed: | Quantitative comparison and metabolite profiling of saponins in different parts of the root of Panax notoginseng. |
| PubMed: | [Screening active components in compound danshen based on PXR-CYP3A4: an experimental study]. |
| PubMed: | Ginsenoside-Rb2 displays anti-osteoporosis effects through reducing oxidative damage and bone-resorbing cytokines during osteogenesis. |
| PubMed: | Pharmacokinetic compatibility of ginsenosides and Schisandra Lignans in Shengmai-san: from the perspective of p-glycoprotein. |
| PubMed: | [Chemical constituents from processed rhizomes of Panax notoginseng]. |
| PubMed: | Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters. |
| PubMed: | [Chemical constituents from roots and rhizomes of Panax ginseng cultivated in Jilin province]. |
| PubMed: | Hydrophilic interaction chromatography for selective separation of isomeric saponins. |
| PubMed: | Benefit of neuroprotection in acute ischaemic stroke, shall we dare to hope? |
| PubMed: | Complete conversion of major protopanaxadiol ginsenosides to compound K by the combined use of α-L-arabinofuranosidase and β-galactosidase from Caldicellulosiruptor saccharolyticus and β-glucosidase from Sulfolobus acidocaldarius. |
| PubMed: | Protective effect of ginsenoside-Rb2 from Korean red ginseng on the lethal infection of haemagglutinating virus of Japan in mice. |
| PubMed: | Isolation and characterization of novel ginsenoside-hydrolyzing glycosidase from Microbacterium esteraromaticum that transforms ginsenoside Rb2 to rare ginsenoside 20(S)-Rg3. |
| PubMed: | Diversity of endophytic fungi from roots of Panax ginseng and their saponin yield capacities. |
| PubMed: | [High-resolution THz spectra of six biological and pharmaceutical materials]. |
| PubMed: | Lactobacillus ginsenosidimutans sp. nov., isolated from kimchi with the ability to transform ginsenosides. |
| PubMed: | Silver (Ι)-assisted enantiomeric analysis of ginsenosides using electrospray ionization tandem mass spectrometry. |
| PubMed: | Enzymatic transformation of the major ginsenoside Rb2 to minor compound Y and compound K by a ginsenoside-hydrolyzing β-glycosidase from Microbacterium esteraromaticum. |
| PubMed: | Cloning and characterization of ginsenoside Ra1-hydrolyzing beta-D-xylosidase from Bifidobacterium breve K-110. |
| PubMed: | Determination of ginsenosides Rb1, Rb2, and Rb3 in rat plasma by a rapid and sensitive liquid chromatography tandem mass spectrometry method: Application in a pharmacokinetic study. |
| PubMed: | Antioxidant, antiproliferative, and pro-apoptotic activities of a saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen. |
| PubMed: | [Determination of astragaloside IV of eight area in Astragali Radix is by HPLC-ELSD internal standard method]. |
| PubMed: | Cloning and characterization of α-L-arabinofuranosidase and bifunctional α-L-arabinopyranosidase/β-D-galactopyranosidase from Bifidobacterium longum H-1. |
| PubMed: | The antidiabetic effect of ginsenoside Rb2 via activation of AMPK. |
| PubMed: | AMP-activated protein kinase: a potential target for ginsenosides? |
| PubMed: | Effect of protopanaxadiol derivatives in high glucose-induced fibronectin expression in primary cultured rat mesangial cells: role of mitogen-activated protein kinases and Akt. |
| PubMed: | [Absorption characteristics of ginsenoside Rb2 in Caco-2 cell monolayer]. |
| PubMed: | On-line concentration of neutral analytes by complexation and acetonitrile sweeping in nonionic microemulsion electrokinetic chromatography with direct ultraviolet detection. |
| PubMed: | The ginsenoside-Rb2 lowers cholesterol and triacylglycerol levels in 3T3-L1 adipocytes cultured under high cholesterol or fatty acids conditions. |
| PubMed: | [A quantitative method using one marker for simultaneous assay of ginsenosides in Panax ginseng and P. notoginseng]. |
| PubMed: | Method development for gypenosides fingerprint by high performance liquid chromatography with diode-array detection and the addition of internal standard. |
| PubMed: | Study on the hydroxyl radical scavenging activity changes of ginseng and ginsenoside-Rb2 by heat processing. |
| PubMed: | Study on the noncovalent complexes of ginsenoside and cytochrome c by electrospray ionization mass spectrometry. |
| PubMed: | Differential effects of ginsenosides on NO and TNF-alpha production by LPS-activated N9 microglia. |
| PubMed: | A ginsenoside metabolite, 20-O-beta-D-glucopyranosyl-20(S)-protopanaxadiol, triggers apoptosis in activated rat hepatic stellate cells via caspase-3 activation. |
| PubMed: | Effects of individual ginsenosides, ginkgolides and flavonoids on CYP2C19 and CYP2D6 activity in human liver microsomes. |
| PubMed: | Transformation of ginsenosides Rb2 and Rc from Panax ginseng by food microorganisms. |
| PubMed: | Protective effect of fermented red ginseng on a transient focal ischemic rats. |
| PubMed: | Simultaneous determination of ginsenoside Rb(1) and Rg(1) in human plasma by liquid chromatography-mass spectrometry. |
| PubMed: | Purification and characterization of alpha-L-arabinopyranosidase and alpha-L-arabinofuranosidase from Bifidobacterium breve K-110, a human intestinal anaerobic bacterium metabolizing ginsenoside Rb2 and Rc. |
| PubMed: | Effects of ginsenosides on carbachol-stimulated formation of inositol phosphates in rat cortical cell cultures. |
| PubMed: | Enhancement of fibrinolytic activity of bovine aortic endothelial cells by ginsenoside Rb2. |
| PubMed: | [Determination of six ginsenosides in Panax species by high performance liquid chromatography]. |
| PubMed: | Ginsenosides from Panax ginseng differentially regulate lymphocyte proliferation. |
| PubMed: | Fecal metabolic activities of herbal components to bioactive compounds. |
| PubMed: | Transcriptional regulation and environmental induction of gene encoding copper- and zinc-containing superoxide dismutase. |
| PubMed: | Epidermis proliferative effect of the Panax ginseng ginsenoside Rb2. |
| PubMed: | Inhibitory effect of ginsenoside-Rb2 on invasiveness of uterine endometrial cancer cells to the basement membrane. |
| PubMed: | Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions. |
| PubMed: | In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists. |
| PubMed: | Effects of Ginsenoside Rb2 and Rc on inferior human sperm motility in vitro. |
| PubMed: | Constitutive beta-glucosidases hydrolyzing ginsenoside Rb1 and Rb2 from human intestinal bacteria. |
| PubMed: | Preventive effect of epicatechin and ginsenoside Rb(2) on the inhibition of gap junctional intercellular communication by TPA and H(2)O(2). |
| PubMed: | Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. |
| PubMed: | [Active constituents reducing side-effects of prednisone acetate in leaves of Panax ginseng C.A.Mey]. |
| PubMed: | Ginsenosides increase secretion of lipoprotein lipase by 3T3-L1 adipocytes. |
| PubMed: | Transcriptional activation of the Cu,Zn-superoxide dismutase gene through the AP2 site by ginsenoside Rb2 extracted from a medicinal plant, Panax ginseng. |
| PubMed: | Molecular biological analysis of the effects of ginsenoside-Rb2 on albumin mRNA in streptozotocin-induced diabetic rats. |
| PubMed: | Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng. |
| PubMed: | Suppression of the formation of sister chromatid exchanges by low concentrations of ginsenoside Rh2 in human blood lymphocytes. |
| PubMed: | [Single calcium channel analysis and electron spin resonance (ESR) spectral study on the myocardial effects of ginsenoside Rb2]. |
| PubMed: | [Protective effects of ginsenoside on myocardiac ischemic and reperfusion injuries]. |
| PubMed: | [Studies on the pharmacodynamics of ginsenoside-Rg1, -Rb1 and -Rb2 in rats]. |
| PubMed: | Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2. |
| PubMed: | Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VIII. Isotope labeling of ginsenoside Rb2. |
| PubMed: | Influences of ginsenosides Rb1, Rb2, and Rb3 on electric and contractile activities of normal and damaged cultured myocardiocytes. |
| PubMed: | Studies on the enzyme immunoassay of bio-active constituents in oriental medicinal drugs. VI. Enzyme immunoassay of ginsenoside Rb1 from Panax ginseng. |
| PubMed: | Inhibitory effect of ginsenosides on migration of arterial smooth muscle cells. |
| PubMed: | Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats. |
| PubMed: | [Effects of panaxadiol and panaxatriol saponins on action potentials of normal and xanthine-xanthine oxidase damaged cultured myocardial cells]. |
| PubMed: | Effects of ginsenoside-Rb2 on adenine nucleotide content of rat hepatic tissue. |
| PubMed: | Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VI. The decomposition products of ginsenoside Rb2 in the stomach of rats. |
| PubMed: | Facilitation of protein biosynthesis by ginsenoside-Rb2 administration in diabetic rats. |
| PubMed: | Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats. |
| PubMed: | The effect of ginsenoside-Rb2 on nitrogen balance. |
| PubMed: | Effect of serial administration of ginsenoside-Rb2 in diabetic rats: in terms of carbohydrate and lipid metabolites. |
| PubMed: | Effect of ginsenoside-Rb2 on nitrogen compounds in streptozotocin-diabetic rats. |
| PubMed: | Specific interaction of arabinose residue in ginsenoside with egg phosphatidylcholine vesicles. |
| PubMed: | Effect of ginsenosides Rg1, Rc and Rb2 on hormone-induced lipolysis and lipogenesis in rat epididymal fat cells. |
| PubMed: | Hyperlipemia-improving effects of ginsenoside-Rb2 in streptozotocin-diabetic rats. |
| PubMed: | Studies on the mechanism of the hypoglycemic activity of ginsenoside-Rb2 in streptozotocin-diabetic rats. |
| PubMed: | Hyperlipemia-improving effects of ginsenoside-Rb2 in cholesterol-fed rats. |
| PubMed: | Stimulation of the lipogenic pathway in ginsenoside-Rb2 treated rats. |
| PubMed: | Stimulation of lipid and sugar metabolism in ginsenoside-Rb2 treated rats. |
| PubMed: | Studies on the biochemical action of ginseng saponin. I. Purification from ginseng extract of the active component stimulating serum protein biosynthesis. |
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