|
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Boiling Point: | 1128.30 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 1177.00 °F. TCC ( 636.20 °C. ) (est)
|
| logP (o/w): | 5.100 (est) |
| Soluble in: |
| | water, 0.3637 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 410 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 539, 1975.
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for ginsenoside Rc usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for ginsenoside Rc flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 20-((6-O-alpha-L- | arabinofuranosyl-beta-D-glucopyranosyl)oxy)-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside | | | ginsenoside RC | | | panaxoside Rc | | | panaxoside RC |
Articles:
| PubMed: | [Screening active components in compound danshen based on PXR-CYP3A4: an experimental study]. |
| PubMed: | Characterization of a ginsenoside-transforming β-glucosidase from Paenibacillus mucilaginosus and its application for enhanced production of minor ginsenoside F₂. |
| PubMed: | Efficacy comparison of Korean ginseng and American ginseng on body temperature and metabolic parameters. |
| PubMed: | Ginsenosides from Korean red ginseng inhibit matrix metalloproteinase-13 expression in articular chondrocytes and prevent cartilage degradation. |
| PubMed: | [Chemical constituents from roots and rhizomes of Panax ginseng cultivated in Jilin province]. |
| PubMed: | Hydrophilic interaction chromatography for selective separation of isomeric saponins. |
| PubMed: | Pharmacokinetic study of ginsenoside Rc and simultaneous determination of its metabolites in rats using RRLC-Q-TOF-MS. |
| PubMed: | Ginsenoside Rc modulates Akt/FoxO1 pathways and suppresses oxidative stress. |
| PubMed: | Mass production of the ginsenoside Rg3(S) through the combinative use of two glycoside hydrolases. |
| PubMed: | Complete conversion of major protopanaxadiol ginsenosides to compound K by the combined use of α-L-arabinofuranosidase and β-galactosidase from Caldicellulosiruptor saccharolyticus and β-glucosidase from Sulfolobus acidocaldarius. |
| PubMed: | Production of ginsenoside Rd from ginsenoside Rc by α-L-arabinofuranosidase from Caldicellulosiruptor saccharolyticus. |
| PubMed: | Diversity of endophytic fungi from roots of Panax ginseng and their saponin yield capacities. |
| PubMed: | Determination of ginsenoside Rc in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. |
| PubMed: | Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus). |
| PubMed: | Lactobacillus ginsenosidimutans sp. nov., isolated from kimchi with the ability to transform ginsenosides. |
| PubMed: | Four new triterpenoid saponins from the leaves of Panax japonicus grown in southern Miyazaki Prefecture (4). |
| PubMed: | Bioconversion of ginsenoside Rc into Rd by a novel α-L-arabinofuranosidase, Abf22-3 from Leuconostoc sp. 22-3: cloning, expression, and enzyme characterization. |
| PubMed: | [Identification of major components of traditional Chinese medicine Naodesheng tablet by HPLC-DAD-MS(n)]. |
| PubMed: | New triterpenoid saponins from fruits specimens of Panax japonicus collected in Kumamoto and Miyazaki prefectures (1). |
| PubMed: | Effects of Ginsenoside Metabolites on GABAA Receptor-Mediated Ion Currents. |
| PubMed: | Characterization of a novel ginsenoside-hydrolyzing α-L-arabinofuranosidase, AbfA, from Rhodanobacter ginsenosidimutans Gsoil 3054T. |
| PubMed: | Effects of natural products on the function of human organic anion transporting polypeptide 1B1. |
| PubMed: | Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans. |
| PubMed: | Cloning and characterization of α-L-arabinofuranosidase and bifunctional α-L-arabinopyranosidase/β-D-galactopyranosidase from Bifidobacterium longum H-1. |
| PubMed: | Differentiation of Panax quinquefolius grown in the USA and China using LC/MS-based chromatographic fingerprinting and chemometric approaches. |
| PubMed: | Microbial transformation of ginsenosides Rb1, Rb3 and Rc by Fusarium sacchari. |
| PubMed: | Effect of protopanaxadiol derivatives in high glucose-induced fibronectin expression in primary cultured rat mesangial cells: role of mitogen-activated protein kinases and Akt. |
| PubMed: | Ginsenoside Rc, an active component of Panax ginseng, stimulates glucose uptake in C2C12 myotubes through an AMPK-dependent mechanism. |
| PubMed: | Dammarane-type glycosides and long chain sesquiterpene glycosides from Gynostemma yixingense. |
| PubMed: | [Comparative studies on the amount of ginsenosides between the crown galls and Chinese medicinal materials of Panax quinquefolium]. |
| PubMed: | Saponins from the processed rhizomes of Polygonatum kingianum. |
| PubMed: | [A quantitative method using one marker for simultaneous assay of ginsenosides in Panax ginseng and P. notoginseng]. |
| PubMed: | Effects of extrusion process variables on extractable ginsenosides in wheat-ginseng extrudates. |
| PubMed: | Ginsenoside compound K production from ginseng root extract by a thermostable beta-glycosidase from Sulfolobus solfataricus. |
| PubMed: | Effects of ginsenosides, active ingredients of Panax ginseng, on development, growth, and life span of Caenorhabditis elegans. |
| PubMed: | Chemical characteristics for different parts of Panax notoginseng using pressurized liquid extraction and HPLC-ELSD. |
| PubMed: | Identification and differentiation of Panax species using ELISA, RAPD and eastern blotting. |
| PubMed: | Ginsenoside extraction from Panax quinquefolium L. (American ginseng) root by using ultrahigh pressure. |
| PubMed: | Transformation of ginsenosides Rb2 and Rc from Panax ginseng by food microorganisms. |
| PubMed: | [The effect of preparation method on the quality of shen-mai injection]. |
| PubMed: | Chromatographic resolution of glucosidic compounds, ginsenosides on polyethersulphone membrane, and its application to the quantitative immunoassay for ginseng saponins. |
| PubMed: | Embryotoxicity study of ginsenoside Rc and Re in in vitro rat whole embryo culture. |
| PubMed: | Determination of ginsenosides Rb1, Rc, and Re in different dosage forms of ginseng by negative ion electrospray liquid chromatography-mass spectrometry. |
| PubMed: | Purification and characterization of alpha-L-arabinopyranosidase and alpha-L-arabinofuranosidase from Bifidobacterium breve K-110, a human intestinal anaerobic bacterium metabolizing ginsenoside Rb2 and Rc. |
| PubMed: | Modulation of G protein alpha-subunit mRNA levels in discrete rat brain regions by cerebroventricular infusion of ginsenoside Rc and Rg1. |
| PubMed: | Ginsenoside Rc and Re stimulate c-fos expression in MCF-7 human breast carcinoma cells. |
| PubMed: | Effects of ginsenosides on GABA(A) receptor channels expressed in Xenopus oocytes. |
| PubMed: | Metabolism of ginsenoside R(c) by human intestinal bacteria and its related antiallergic activity. |
| PubMed: | Effects of ginsenosides on vanilloid receptor (VR1) channels expressed in Xenopus oocytes. |
| PubMed: | Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions. |
| PubMed: | Changes of [3H]MK-801, [3H]muscimol and [3H]flunitrazepam binding in rat brain by the prolonged ventricular infusion of ginsenoside Rc and Rg1. |
| PubMed: | In vitro inhibitory effect of protopanaxadiol ginsenosides on tumor necrosis factor (TNF)-alpha production and its modulation by known TNF-alpha antagonists. |
| PubMed: | Effects of Ginsenoside Rb2 and Rc on inferior human sperm motility in vitro. |
| PubMed: | Effects of naturally occurring glucosides, solasodine glucosides, ginsenosides and parishin derivatives on multidrug resistance of lymphoma cells and leukocyte functions. |
| PubMed: | Ginsenoside Rc and Rg1 differentially modulate NMDA receptor subunit mRNA levels after intracerebroventricular infusion in rats. |
| PubMed: | High production of ginsenosides by transformed root cultures of Panax ginseng: effect of basal medium and Agrobacterium rhizogenes strains. |
| PubMed: | Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity. |
| PubMed: | Ginsenosides that produce differential antinociception in mice. |
| PubMed: | Formation of monoclonal antibody against a major ginseng component, ginsenoside Rb1 and its characterization. |
| PubMed: | Role of human intestinal Prevotella oris in hydrolyzing ginseng saponins. |
| PubMed: | Saponins from Vietnamese Ginseng, Panax vietnamensis HA et Grushv. Collected in central Vietnam. II. |
| PubMed: | Interactions of ginsenosides with ligand-bindings of GABA(A) and GABA(B) receptors. |
| PubMed: | [Saponins in fruits pedicels of Panax notoginseng (Burk.). F.H. Chen]. |
| PubMed: | Specific interaction of arabinose residue in ginsenoside with egg phosphatidylcholine vesicles. |
| PubMed: | Effect of ginsenosides Rg1, Rc and Rb2 on hormone-induced lipolysis and lipogenesis in rat epididymal fat cells. |
| PubMed: | Saponins can cause the agglutination of phospholipid vesicles. |
| PubMed: | [Chemical constituents of flower-buds of Panax ginseng--isolation and identification of ginsenoside-Rb3 and ginsenoside-Rc]. |
|