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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 889.60 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 917.00 °F. TCC ( 491.80 °C. ) (est)
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| logP (o/w): | 6.830 (est) |
| Soluble in: |
| | water, 0.06564 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 1340 mg/kg Arzneimittel-Forschung. Drug Research. Vol. 25, Pg. 343, 1975.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for ginsenoside Rg2 usage levels up to: | | | not for fragrance use.
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| Recommendation for ginsenoside Rg2 flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | chikusetsusaponin I | | beta-D- | glucopyranoside, (3-beta,6-alpha,12-beta)-3,12,20-trihydroxydammar-24-en-6-yl-2-o-(6-deoxy-alpha-l-mannopyranosyl)- | | | prosapogenin C2 | | (6)-(alpha-L- | rhamnopyranosyl(1-rham-2-glu)-beta-D-glucopyranosyl)-20S-protopanaxatriol |
Articles:
| PubMed: | Antiviral activity of ginsenosides against coxsackievirus B3, enterovirus 71, and human rhinovirus 3. |
| PubMed: | Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells. |
| PubMed: | Simultaneous determination of timosaponin B-II and A-III in rat plasma by LC-MS/MS and its application to pharmacokinetic study. |
| PubMed: | Identification and characterization of a ginsenoside-transforming β-glucosidase from Pseudonocardia sp. Gsoil 1536 and its application for enhanced production of minor ginsenoside Rg2(S). |
| PubMed: | [Chemical constituents from processed rhizomes of Panax notoginseng]. |
| PubMed: | [Chemical constituents from roots and rhizomes of Panax ginseng cultivated in Jilin province]. |
| PubMed: | Changes in ginsenoside composition of ginseng berry extracts after a microwave and vinegar process. |
| PubMed: | [Quality variation and ecotype division of Panax quinquefolium in China]. |
| PubMed: | A comparative study on anticoagulant activities of three Chinese herbal medicines from the genus Panax and anticoagulant activities of ginsenosides Rg1 and Rg2. |
| PubMed: | Ginsenoside rg2 inhibits lipopolysaccharide-induced adhesion molecule expression in human umbilical vein endothelial cell. |
| PubMed: | [Screening of pregnane X receptor activation from ginsenosides]. |
| PubMed: | Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus). |
| PubMed: | State-of-the-art separation of ginsenosides from Korean white and red ginseng by countercurrent chromatography. |
| PubMed: | Metabolite profiling of ginsenoside Re in rat urine and faeces after oral administration. |
| PubMed: | Biotransformation of ginsenosides Re and Rg1 into ginsenosides Rg2 and Rh1 by recombinant β-glucosidase. |
| PubMed: | Changes in the Contents of Prosapogenin in the Red Ginseng (Panax ginseng) Depending on Steaming Batches. |
| PubMed: | Protective effects of Rg2 on hypoxia-induced neuronal damage in hippocampal neurons. |
| PubMed: | Ginsenoside Rg2 induces orphan nuclear receptor SHP gene expression and inactivates GSK3β via AMP-activated protein kinase to inhibit hepatic glucose production in HepG2 cells. |
| PubMed: | [Chemical constituents of Chinese red ginseng]. |
| PubMed: | Effects of ginsenoside Rg2 on the ultraviolet B-induced DNA damage responses in HaCaT cells. |
| PubMed: | Panajaponin, a new glycosphingolipid from Panax japonicus. |
| PubMed: | Dammarane-type glycosides and long chain sesquiterpene glycosides from Gynostemma yixingense. |
| PubMed: | [Metabolic study of ginsenoside Re in rats]. |
| PubMed: | [Study on excretion of ginsenoside Rg2 in rats]. |
| PubMed: | Simultaneous determination of nucleobases, nucleosides and saponins in Panax notoginseng using multiple columns high performance liquid chromatography. |
| PubMed: | [Effects of 3 genosides on bio-thermodynamic expression of splenic lymphocyte in mice]. |
| PubMed: | Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia. |
| PubMed: | Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea. |
| PubMed: | Effects of mRg2, a mixture of ginsenosides containing 60% Rg2, on the ultraviolet B-induced DNA repair synthesis and apoptosis in NIH3T3 cells. |
| PubMed: | Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells. |
| PubMed: | Simultaneous enantiomer determination of 20 (R)- and 20 (S)-ginsenoside-Rg2 in rat plasma after intravenous administration using HPLC method. |
| PubMed: | Extraction of 20(S)-ginsenoside Rg2 from cultured Panax notoginseng cells in vitro stimulates human umbilical cord vein endothelial cell proliferation. |
| PubMed: | [Effect of ginsenoside Rg2 on chemical myocardial ischemia in rats]. |
| PubMed: | Differential effect of ginsenoside metabolites on the 5-HT3A receptor-mediated ion current in Xenopus oocytes. |
| PubMed: | [Study on the chemical constituents of the roots of commercial ginseng]. |
| PubMed: | Differential effect of bovine serum albumin on ginsenoside metabolite-induced inhibition of alpha3beta4 nicotinic acetylcholine receptor expressed in Xenopus oocytes. |
| PubMed: | [Effect of Rg2 on hemodynamics of hemorrhagic shock and its antioxidation in dogs]. |
| PubMed: | Enzymatic preparation of ginsenosides Rg2, Rh1, and F1 from protopanaxatriol-type ginseng saponin mixture. |
| PubMed: | Enzymatic preparation of ginsenosides Rg2, Rh1, and F1. |
| PubMed: | Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes. |
| PubMed: | [Practical optimization of the two-dimensional thin-layer chromatographic separation of ginsenosides]. |
| PubMed: | Effects of ginsenoside Rg2 on human neuronal nicotinic acetylcholine receptors. |
| PubMed: | Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes. |
| PubMed: | Purification and characterization of ginsenoside-alpha-L-rhamnosidase. |
| PubMed: | Characterization of ginseng saponin ginsenoside-Rg(3) inhibition of catecholamine secretion in bovine adrenal chromaffin cells. |
| PubMed: | Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions. |
| PubMed: | Enzymatic synthesis of two ginsenoside Re-beta-xylosides. |
| PubMed: | Enzymatic preparation of genuine prosapogenin, 20(S)-ginsenoside Rh1, from ginsenosides Re and Rg1. |
| PubMed: | Preparation of monoclonal antibody against ginsenoside Rf and its enzyme immunoassay. |
| PubMed: | Effects of ginseng saponins on responses induced by various receptor stimuli. |
| PubMed: | Determination of ginsenoside Rf and Rg2 from Panax ginseng using enzyme immunoassay. |
| PubMed: | Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells. |
| PubMed: | Inhibition of in vitro tumor cell invasion by ginsenoside Rg3. |
| PubMed: | Ginseng saponins reduce acetylcholine-evoked Na+ influx and catecholamine secretion in bovine adrenal chromaffin cells. |
| PubMed: | Effect of 20(S)-ginsenoside-Rg2 and cyproheptadine on two-way active avoidance learning and memory in rats. |
| PubMed: | [Separation of 20(S)-ginsenoside-Rg2 and its 20(R) epimer by reversed phase low pressure column (Rp-18) chromatography]. |
| PubMed: | [Dammarane-type saponins in leaves of Panax collected in Sichuan]. |
| PubMed: | Antiplatelet actions of panaxynol and ginsenosides isolated from ginseng. |
| PubMed: | [Isolation and identification of saponin IV, V, VI and VII in ginseng stems]. |
| PubMed: | [Rhizoma ginseng (III)--Isolation and identification of saponins E1 and E2]. |
| PubMed: | Stimulation of the lipogenic pathway in ginsenoside-Rb2 treated rats. |
| PubMed: | Isolation and characterization of ginsenoside-Rg2, 20R-prosapogenin, 20S-prosapogenin and delta 20-prosapogenin. Chemical studies on saponins of Panax ginseng C. A. Meyer, Third report. |
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