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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 755.10 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 771.00 °F. TCC ( 410.50 °C. ) (est)
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| logP (o/w): | 3.740 (est) |
| Soluble in: |
| | water, 0.07331 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for ginsenoside Rh1 usage levels up to: | | | not for fragrance use.
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| Recommendation for ginsenoside Rh1 flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | ginsenoside RH1 | | beta-D- | glucopyranoside, (3beta,6alpha,12beta)-3,12,20-trihydroxydammar-24-en-6-yl |
Articles:
| PubMed: | Cloning and heterologous expression of UDP-glycosyltransferase genes from Bacillus subtilis and its application in the glycosylation of ginsenoside Rh1. |
| PubMed: | Detoxifying effect of fermented black ginseng on H2O2-induced oxidative stress in HepG2 cells. |
| PubMed: | Ginsenoside Rh1 induces mouse osteoblast growth and differentiation through the bone morphogenetic protein 2/runt-related gene 2 signalling pathway. |
| PubMed: | Characterization of β-xylosidase from Thermoanaerobacterium thermosaccharolyticum and its application to the production of ginsenosides Rg1 and Rh 1 from notoginsenosides R 1 and R 2. |
| PubMed: | Ginsenoside Rb1 eliminates HIV-1 (D3)-transduced cytoprotective human macrophages by inhibiting the AKT pathway. |
| PubMed: | Ginsenoside Rh1 potentiates dexamethasone's anti-inflammatory effects for chronic inflammatory disease by reversing dexamethasone-induced resistance. |
| PubMed: | [Chemical constituents from processed rhizomes of Panax notoginseng]. |
| PubMed: | Quality characteristics and ginsenosides composition of ginseng-yakju according to the particle size of ginseng powder. |
| PubMed: | Long-term administration of ginsenoside Rh1 enhances learning and memory by promoting cell survival in the mouse hippocampus. |
| PubMed: | Ginsenoside Rh1 eliminates the cytoprotective phenotype of human immunodeficiency virus type 1-transduced human macrophages by inhibiting the phosphorylation of pyruvate dehydrogenase lipoamide kinase isozyme 1. |
| PubMed: | Protopanaxatriol ginsenoside Rh1 inhibits the expression of matrix metalloproteinases and the in vitro invasion/migration of human astroglioma cells. |
| PubMed: | Comparative pharmacokinetics of timosaponin B-II and timosaponin A-III after oral administration of Zhimu-Baihe herb-pair, Zhimu extract, free timosaponin B-II and free timosaponin A-III to rats. |
| PubMed: | Ginsenoside Rh1 ameliorates high fat diet-induced obesity in mice by inhibiting adipocyte differentiation. |
| PubMed: | Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus). |
| PubMed: | Antibiotics attenuate anti-scratching behavioral effect of ginsenoside Re in mice. |
| PubMed: | Effect of ginsenoside Rh1 on myocardial injury and heart function in isoproterenol-induced cardiotoxicity in rats. |
| PubMed: | Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells. |
| PubMed: | Biotransformation of ginsenosides Re and Rg1 into ginsenosides Rg2 and Rh1 by recombinant β-glucosidase. |
| PubMed: | Chemical Diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng. |
| PubMed: | Effects of Minor Ginsenosides, Ginsenoside Metabolites, and Ginsenoside Epimers on the Growth of Caenorhabditis elegans. |
| PubMed: | Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway. |
| PubMed: | [Chemical constituents of Chinese red ginseng]. |
| PubMed: | Oral administration of ginsenoside Rh1 inhibits the development of atopic dermatitis-like skin lesions induced by oxazolone in hairless mice. |
| PubMed: | [Raman spectroscopy study on the interaction of ginsenoside Rb1 with DPPC bilayers]. |
| PubMed: | Post-exposure treatment with ginsenoside compound K ameliorates auditory functional injury associated with noise-induced hearing loss in mice. |
| PubMed: | Anti-inflammatory mechanism of ginsenoside Rh1 in lipopolysaccharide-stimulated microglia: critical role of the protein kinase A pathway and hemeoxygenase-1 expression. |
| PubMed: | [Pharmacokinetics of ginsenosides Rg1 and its metabolites in rats]. |
| PubMed: | Microsomal cytochrome p450-mediated metabolism of protopanaxatriol ginsenosides: metabolite profile, reaction phenotyping, and structure-metabolism relationship. |
| PubMed: | Ginsenoside Rh1 suppresses inducible nitric oxide synthase gene expression in IFN-gamma-stimulated microglia via modulation of JAK/STAT and ERK signaling pathways. |
| PubMed: | [Determination and enzymolysis preparation of ginsenoside Rh1]. |
| PubMed: | Dammarane-type glycosides and long chain sesquiterpene glycosides from Gynostemma yixingense. |
| PubMed: | [Metabolic study of ginsenoside Re in rats]. |
| PubMed: | Biotransformation of ginsenoside Rf to Rh1 by recombinant beta-glucosidase. |
| PubMed: | Improvement of memory in mice and increase of hippocampal excitability in rats by ginsenoside Rg1's metabolites ginsenoside Rh1 and protopanaxatriol. |
| PubMed: | Characterization of pharmacokinetic profiles and metabolic pathways of 20(S)-ginsenoside Rh1 in vivo and in vitro. |
| PubMed: | [A quantitative method using one marker for simultaneous assay of ginsenosides in Panax ginseng and P. notoginseng]. |
| PubMed: | Determination of 20(S)-ginsenoside Rh1 and its aglycone 20(S)-protopanaxatriol in rat plasma by sensitive LC-APCI-MS method and its application to pharmacokinetic study. |
| PubMed: | Protective effect of ginsenosides Rg(2) and Rh(1) on oxidation-induced impairment of erythrocyte membrane properties. |
| PubMed: | Simultaneous determination of nucleobases, nucleosides and saponins in Panax notoginseng using multiple columns high performance liquid chromatography. |
| PubMed: | Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells. |
| PubMed: | Screening of anti-platelet aggregation agents from Panax notoginseng using human platelet extraction and HPLC-DAD-ESI-MS/MS. |
| PubMed: | [Studies on chemical constituents from rhizomes of Panax notoginseng]. |
| PubMed: | Microbial transformation of 20(S)-protopanaxatriol-type saponins by Absidia coerulea. |
| PubMed: | An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. |
| PubMed: | The effects of ginsenoside Re and its metabolite, ginsenoside Rh1, on 12-O-tetradecanoylphorbol 13-acetate- and oxazolone-induced mouse dermatitis models. |
| PubMed: | Influence of ginsenoside Rh1 and F1 on human cytochrome p450 enzymes. |
| PubMed: | Metabolism of ginsenoside Re by human intestinal microflora and its estrogenic effect. |
| PubMed: | Simultaneous rapid quantification of ginsenoside Rg1 and its secondary glycoside Rh1 and aglycone protopanaxatriol in rat plasma by liquid chromatography-mass spectrometry after solid-phase extraction. |
| PubMed: | [Isolation and identification of minor bioactive saponins from the leaves of Panax notoginseng]. |
| PubMed: | Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. |
| PubMed: | Degradation of ginsenosides in humans after oral administration. |
| PubMed: | A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. |
| PubMed: | Enzymatic preparation of ginsenosides Rg2, Rh1, and F1 from protopanaxatriol-type ginseng saponin mixture. |
| PubMed: | Enzymatic preparation of ginsenosides Rg2, Rh1, and F1. |
| PubMed: | [Saponins with low sugar chain from the leaves of Panax notoginseng (Burk) F. H. Chen]. |
| PubMed: | Purification and characterization of ginsenoside-alpha-L-rhamnosidase. |
| PubMed: | Anticarcinogenic effect of Panax ginseng C.A. Meyer and identification of active compounds. |
| PubMed: | In vitro anti-Helicobacter pylori activity of panaxytriol isolated from ginseng. |
| PubMed: | Metabolism of ginsenoside Rg1 by intestinal bacteria. II. Immunological activity of ginsenoside Rg1 and Rh1. |
| PubMed: | Effects of ginsenosides from Panax ginseng on cell-to-cell communication function mediated by gap junctions. |
| PubMed: | Enzymatic preparation of genuine prosapogenin, 20(S)-ginsenoside Rh1, from ginsenosides Re and Rg1. |
| PubMed: | Ginsenoside Rh2 and Rh3 induce differentiation of HL-60 cells into granulocytes: modulation of protein kinase C isoforms during differentiation by ginsenoside Rh2. |
| PubMed: | Modulation of protein kinase C activity in NIH 3T3 cells by plant glycosides from Panax ginseng. |
| PubMed: | Ginsenosides increase secretion of lipoprotein lipase by 3T3-L1 adipocytes. |
| PubMed: | Ginsenoside-Rh1 and Rh2 inhibit the induction of nitric oxide synthesis in murine peritoneal macrophages. |
| PubMed: | Determination of aglycones of ginsenosides in ginseng preparations sold in Sweden and in urine samples from Swedish athletes consuming ginseng. |
| PubMed: | Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. Collected in central Vietnam. I. |
| PubMed: | Control of phenotypic expression of cultured B16 melanoma cells by plant glycosides. |
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