gitoxin, 4562-36-1

Articles:

PubMed:	Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase.
PubMed:	A structural view on the functional importance of the sugar moiety and steroid hydroxyls of cardiotonic steroids in binding to Na,K-ATPase.
PubMed:	HPLC method validation for Digitalis and its analogue by pulsed amperometric detection.
PubMed:	Simple coacervates of zein to encapsulate Gitoxin.
PubMed:	Effects of digoxin and gitoxin on the enzymatic activity and kinetic parameters of Na+/K+-ATPase.
PubMed:	Anti-tumour activity of Digitalis purpurea L. subsp. heywoodii.
PubMed:	Modifying specificity of antidigoxin antibodies using insertional mutagenesis.
PubMed:	Complementary combining site contact residue mutations of the anti-digoxin Fab 26-10 permit high affinity wild-type binding.
PubMed:	A single H:CDR3 residue in the anti-digoxin antibody 26-10 modulates specificity for C16-substituted digoxin analogs.
PubMed:	Phage display-selected sequences of the heavy-chain CDR3 loop of the anti-digoxin antibody 26-10 define a high affinity binding site for position 16-substituted analogs of digoxin.
PubMed:	A non-fatal case of intoxication with foxglove, documented by means of liquid chromatography-electrospray-mass spectrometry.
PubMed:	Cardiovascular activity of a methanolic extract of Digitalis purpurea spp. heywoodii.
PubMed:	Multiresidue screen for cardiotoxins by two-dimensional thin-layer chromatography.
PubMed:	Monoclonal antibodies that distinguish between two related digitalis glycosides, ouabain and digoxin.
PubMed:	Induction of digoxin-like material production, and the digoxin binding in the unicellular organism Tetrahymena by digitoxin.
PubMed:	Studies on cardiac ingredients of plants. XIII: Chemical modification of gitoxin to cardiotonic compounds without vascular effect.
PubMed:	Ultra-specific immunoassays for small molecules: roles of wash steps and multiple binding formats.
PubMed:	Structure and specificity of the anti-digoxin antibody 40-50.
PubMed:	Extraordinary efficacy of 16 alpha-gitoxin, an ultra-short acting semi-synthetic digitalis glycoside.
PubMed:	Recovery of digoxin and related glycosides from an injection dosage form by liquid-liquid and solid-phase extraction.
PubMed:	High-performance thin-layer chromatographic determination of digoxin and related compounds, digoxigenin bisdigitoxoside and gitoxin, in digoxin drug substance and tablets.
PubMed:	Altered hapten recognition by two anti-digoxin hybridoma variants due to variable region point mutations.
PubMed:	High-performance liquid chromatographic determination of secondary cardiac glycosides in Digitalis purpurea leaves.
PubMed:	High sensitivity of the Na+, K+-pump of human red blood cells to genins of cardiac glycosides.
PubMed:	Pharmacokinetics of pengitoxin and its therapeutic efficacy in congestive heart failure.
PubMed:	Human cell mutants affected in the interaction of the 12 beta-OH group of cardiac glycosides with the digitalis receptor.
PubMed:	Elimination of 16-acetyl-gitoxin in patients suffering from impaired liver function.
PubMed:	Dose-dependent shortening of systolic time intervals after intake of pengitoxin.
PubMed:	Uptake and liberation of [3H]16-acetyl-gitoxin in the isolated guinea pig atrium.
PubMed:	On the pharmacokinetics of 16-acetyl-gitoxin and its bioavailability from pengitoxin-containing tablet formulations.
PubMed:	Cellular basis for the species differences in sensitivity to cardiac glycosides (digitalis).
PubMed:	Laser desorption/Fourier transform mass spectra of glycoalkaloids and steroid glycosides.
PubMed:	Biochemical and cross-resistance studies with HeLa cell mutants resistant to cardiac glycoside SC4453. Regulation of the resistant form of Na+/K+-ATPase in the mutant cells.
PubMed:	A new alternative in the field of cardiac glycosides: gitoxin.
PubMed:	Gitoxin--a challenger for digoxin?
PubMed:	Cross-resistance and biochemical studies with two classes of HeLa cell mutants resistant to cardiac glycosides. The unusual behavior of cardenolide SC4453.
PubMed:	A further study of the pharmacokinetics of gitoxin in rabbit isolated liver: clearance of 3H-gitoxin.
PubMed:	Synthesis and biological activity of some cardiotonic compounds related to gitoxigenin.
PubMed:	[Plasma levels of gitoxin (by RIA and rubidium-86 uptake) and systolic time after treatment with a single dose of gitoformate].
PubMed:	Hepatic clearance of gitoxin. Metabolism and biliary excretion by rabbit isolated liver.
PubMed:	Therapeutic range of cardiac glycosides.
PubMed:	Hepatic clearance of gitoxin: pharmacokinetic study on rabbit isolated liver. Influence of protein binding and comparison with digoxin.
PubMed:	On the pharmacokinetics of pengitoxin and its cardioactive derivative 16-acetyl-gitoxin.
PubMed:	Metabolism of gitoxin by the rabbit isolated liver.
PubMed:	Bio-Transformation of (G-3H)-digitoxin and (G-3H)-digoxin by Digitalis purpurea.
PubMed:	Studies on the pharmacokinetics and the metabolism of gitoxin in the guinea-pig: II. the enteral absorption and the enterohepatic recirculation.
PubMed:	Separation of digoxin, digitoxin and their potential metabolites, impurities or degradation products by high-performance liquid chromatography.
PubMed:	Isolation and mass spectrometric identification of gitoxin metabolites excreted in bile.
PubMed:	Contrasting effect on cardiac output of digoxin and gitoxin in humans during congestive heart failure.
PubMed:	Cardiac glycosides and their metabolites levels in plasma and heart of guinea-pigs after I. V. administration.
PubMed:	On the plasma protein binding of 16-acetyl-gitoxin.
PubMed:	Reverse phase thin layer chromatographic procedure for identification of digoxin and related fluorescing substances.
PubMed:	Direct radioimmunoassay for the determination of 16-acetyl-gitoxin in serum.
PubMed:	Studies on the pharmacokinetics and the metabolism of gitoxin in the guinea-pig: I. Disposition kinetics following an i.v. bolus of 3H-gitoxin.
PubMed:	Studies on cardioactive steroids. V. Structure-activity relationships of derivatives of 16 alpha-gitoxin.
PubMed:	Binding of digitoxin, digoxin and gitoxin to human serum albumin.
PubMed:	Uptake and pharmacological effect of gitoxin and gitaloxin in rat and guinea-pig perfused hearts. Comparison with digitoxin and digoxin.
PubMed:	The binding of gitoxin to human plasma proteins.
PubMed:	Perfusion of rabbit's liver with gitoxin: application of a model of compartmental analysis to preliminary results.
PubMed:	Comparative study of the pharmacological effects and the binding of gitoxin, gitaloxin, digitoxin and digoxin to isolated guinea-pig hearts.
PubMed:	Bioavailability study of gitoxin in a solid dosage form.
PubMed:	[Comparative study of myocardial and plasma radioactivity following bolus injections of various amounts of tritiated gitoxin, digitoxin and digoxin to guinea-pigs (author's transl)].
PubMed:	[Kinetic of elimination of gitoxin by isolated and perfused rabbit liver: application of two models for compartmental analysis (author's transl)].
PubMed:	[Preliminary aspects of the distribution and elimination of tritiated gitoxin in guinea-pig (author's transl)].
PubMed:	Investigation into the species-specific deacylation of penta-acetyl-gitoxin.
PubMed:	Pharmacological reevaluation of gitoxin in man.
PubMed:	Reduction of the equilibrium binding of cardiac glycosides and related compounds to Na+,K+-ATPase as a possible mechanism for the potassium-induced reversal of their toxicity.
PubMed:	Measurement of plasma glycoside level following pengitoxin administration.
PubMed:	[Clinical experience with the cardiac glycoside Gitoformat (author's transl)].
PubMed:	Pharmacokinetic investigations with 3H-penta-acetyl-gitoxin in volunteers and patients with respect to the occurrence of drug latentiation.
PubMed:	Cardiac effects of 16-acetyl-gitoxin, the active glycoside after penta-acetyl-gitoxin administration.
PubMed:	Kinetic properties of 3H-16alpha-gitoxin in the isolated guinea-pig atrium.
PubMed:	Pharmacokinetic investigations in man of two acetyl derivatives of 16alpha-gitoxin.
PubMed:	Penta-acetyl-gitoxin: the prototype of a prodrug in the cardiac glycoside series.
PubMed:	Binding of 16alpha-gitoxin and its 16-acetate to human serum albumin.
PubMed:	Absorption and metabolism in man of 16-epi-gitoxin, a new semi-synthetic cardioactive glycoside.
PubMed:	Some pharmacological studies on the cardiotonic effects of furanosteroidal glycosides.
PubMed:	Extraordinary cardiac effects of 16-epi-gitoxin in comparison to ouabain in cats and dogs.
PubMed:	[Fluorescent method of determining the activity of gitoxin].
PubMed:	Different toxic effects of ouabain and 16-epi-gitoxin on Purkinje fibres and ventricular muscle fibres.
PubMed:	Isolation and quantitation of picomole quantities of digoxin, digitoxin and their metabolites by high-pressure liquid chromatography.
PubMed:	Studies on cardioactive steroids. III. Characterization of different cardiac glycosides by their effects on contractility and rhythmicity at different extracellular potassium concentrations.
PubMed:	[Cardiac effect of a new penta-acetylated gitoxin (pengitoxin)].
PubMed:	[Resorption of derivatives of gitoxin and helveticosol in rat jejunum].
PubMed:	Quantitative determination of digitoxin, gitaloxin, gitoxin, verodoxin and strospesid in the leaves of Digitalis purpurea by means of fluorescence.
PubMed:	Comparison of therapeutic and toxic actions of ouabain, gitoxin and 16-epi-gitoxin on isolated atria at different extracellular potassium concentrations.
PubMed:	Rapid identification and estimation of gitoxin in digitoxin and digoxin tablets by TLC.
PubMed:	[Application of diffuse reflection and fluorescence for direct determination of digitaloids on chromatographic plates. 1. Determination of digitoxin, gitoxin and digoxin by fluorescence].
PubMed:	[Spectrophotometric method for the quantitative determination of digitoxin, gitoxin, celanide and digoxin].
PubMed:	Different relationships between therapeutic and toxic actions of 16-epi-gitoxin, gitoxin and ouabain on isolated cardiac preparations.
PubMed:	Colorimetric assay of digitoxin and gitoxin in mixtures after thin-layer chromatographic separation.
PubMed:	A fluorometric determination of myocardial digoxin at autopsy, with identification of digitalis leaf, digitoxin, and gitoxin.
PubMed:	Studies on digitalis glycosides. Gitoxin acetates. 2. Deacetylation of pentaacetylgitoxin with liver and heart homogenates.
PubMed:	Studies on digitalis glycosides. XXVI. Gitoxin acetates. (1). Deacetylation of pentaacetylgitoxin.
PubMed:	[Identification of a mono-formyl-xi-gitoxin obtained after formylation of gitoxin].
PubMed:	[Determination of digitoxin and gitoxin in digitalis leaves according to the foregoing thin-layer chromatographic isolation].
PubMed:	Clinical trial of a new cardiotonic agent: AC 2770, a pentaformylated derivative of gitoxin.
PubMed:	[CARDIAC THERAPY WITH PENTA-ACETYL-GITOXIN, A NEW HALF-SYNTHETIC PURPUREAGLYCOSIDE].
PubMed:	[CLINICAL TRIAL OF A NEW CARDIOTONIC AGENT (16-FORMYL-GITOXIN) IN PATIENTS WITH CARDIAC INSUFFICIENCY].
PubMed:	[CLINICAL STUDY OF A NEW DIGITALIS DRUG: 16-FORMYL-GITOXIN].
PubMed:	[The determination of gitoxin].
PubMed:	[Analysis of the cardiotonic activity of gitoxin and gitoxigenin in the guinea pig].
PubMed:	[Preparation of pure digitoxin & gitoxin].
PubMed:	Studies on digitalis glycosides: acetylgitoxin-alpha from gitoxin.
PubMed:	Studies on digitalis glycosides. VII. Gitoroside, digitalonin, and gitoxin pentaacetate.
PubMed:	[Effect of gitoxin on the cardiovascular system].
PubMed:	[Method of chemical assay of digitoxin-gitoxin mixtures and digitalis drugs].
PubMed:	[Clinical studies on gitoxin. I. The problem of the effects of enteral gitoxin administration on the human heart].
PubMed:	[Investigations on pharmacodynamics of gitoxin].
PubMed:	[Clinical use of digitalis; combined digitoxin and gitoxin (crystafolin CIBA) in the therapy of cardiovascular disorders].
PubMed:	[The fluorometric determination of gitoxin].
PubMed:	[Enteral resorption of lanatosid A, B and C and gitoxin in cat and dog].
PubMed:	Paper-chromatographic separation and fluorimetric determination of gitoxigenin, gitoxin, and purpureaglycoside B.
PubMed:	[Enteral resorption of digitoxin and gitoxin].
PubMed:	[Biologic evaluation of the effects of gitoxin with the aid of a surface active solvent].
PubMed:	A polarographic method for the determination of digitoxin and gitoxin and its application to pharmacological studies.