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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 679.30 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 501.00 °F. TCC ( 260.60 °C. ) (est)
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| logP (o/w): | 1.160 (est) |
| Soluble in: |
| | water, 5119 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for gossypetin usage levels up to: | | | not for fragrance use.
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| Recommendation for gossypetin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5280647 |
| Pubchem (sid): | 135227191 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | articulatidin | | 4H-1- | benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy- | | 2-(3,4- | dihydroxyphenyl)-3,5,7,8-tetrahydroxychromen-4-one | | | equisporol | | 3,5,7,8,3',4'- | hexahydroxyflavone |
Articles:
| PubMed: | Protective effect of Urtica dioica methanol extract against experimentally induced urinary calculi in rats. |
| PubMed: | Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells--A SAR study. |
| PubMed: | Antiartherosclerotic effects of plant flavonoids. |
| PubMed: | [Chemical constituents of leaves of Psidium guajava]. |
| PubMed: | Anti-atherosclerotic potential of gossypetin via inhibiting LDL oxidation and foam cell formation. |
| PubMed: | LC-NMR, NMR, and LC-MS identification and LC-DAD quantification of flavonoids and ellagic acid derivatives in Drosera peltata. |
| PubMed: | Gossypetin, a naturally occurring hexahydroxy flavone, ameliorates gamma radiation-mediated DNA damage. |
| PubMed: | A critical evaluation on the reliability of two aluminum chloride chelation methods for quantification of flavonoids. |
| PubMed: | [Study on chemical constituents of Drosera peltata var. multisepala]. |
| PubMed: | Flavonoid constituents and free radical scavenging activity of Alchemilla mollis. |
| PubMed: | [Metabolites in rat urine after orally administrating gossypetin-8-O-beta-D-glucuronide]. |
| PubMed: | Semisynthesis of natural flavones inhibiting tubulin polymerization, from hesperidin. |
| PubMed: | Characterization of inhibitor-bound alpha-synuclein dimer: role of alpha-synuclein N-terminal region in dimerization and inhibitor binding. |
| PubMed: | Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. |
| PubMed: | Comparative analysis of flavonoid profile, antioxidant and antimicrobial activity of the berries of Juniperus communis L. var. communis and Juniperus communis L. var. saxatilis Pall. from Turkey. |
| PubMed: | Metabolism of hibifolin by human intestinal bacteria. |
| PubMed: | Chemodiversity of exudate flavonoids in Cassinia and Ozothamnus (Asteraceae, Gnaphalieae). |
| PubMed: | Screening of herbal constituents for aromatase inhibitory activity. |
| PubMed: | Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells. |
| PubMed: | Metabolic profiling of flavonoids in Lotus japonicus using liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry. |
| PubMed: | Anti-oxidant constituents from Sedum takesimense. |
| PubMed: | Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis. |
| PubMed: | Bioactive compounds from Rhodiola rosea (Crassulaceae). |
| PubMed: | Antioxidant phenolic constituents from Fagopyrum dibotrys. |
| PubMed: | Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. |
| PubMed: | Polyoxygenated flavonoids from Eugenia edulis. |
| PubMed: | Electrospray mass spectrometric decomposition of some glucuronic acid-containing flavonoid diglycosides. |
| PubMed: | Chemical constituents of Pyrrosia petiolosa. |
| PubMed: | New erythroxane-type diterpenoids from Fagonia boveana (Hadidi) Hadidi & Graf. |
| PubMed: | A novel flavonol lyxoside of Orostachys japonicus herb. |
| PubMed: | UDP-glucose: flavonol 7-O-glucosyltransferase activity in flower extracts of Chrysanthemum segetum. |
| PubMed: | Bioactive constituents of Chinese natural medicines. II. Rhodiolae radix. (1). Chemical structures and antiallergic activity of rhodiocyanosides A and B from the underground part of Rhodiola quadrifida (Pall.) Fisch. et Mey. (Crassulaceae). |
| PubMed: | Rhodiocyanosides A and B, new antiallergic cyanoglycosides from Chinese natural medicine "si lie hong jing tian", the underground part of Rhodiola quadrifida (Pall.) Fisch. et Mey. |
| PubMed: | Dietary flavonoids in atherosclerosis prevention. |
| PubMed: | The modification of low density lipoprotein by the flavonoids myricetin and gossypetin. |
| PubMed: | Evaluation of flavonoids inGossypium arboreum (L.) cottons as potential source of resistance to tobacco budworm. |
| PubMed: | Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids. |
| PubMed: | Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages. |
| PubMed: | Inhibition of sheep platelet arachidonate metabolism by flavonoids from Spanish and Indian medicinal herbs. |
| PubMed: | Modulating effect of plant flavonoids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine. |
| PubMed: | Loss of plasmid linked antibiotic resistance in Escherichia coli on treatment with some phenolic compounds. |
| PubMed: | C18 solid-phase isolation and high-performance liquid chromatography/ultraviolet diode array determination of fully methoxylated flavones in citrus juices. |
| PubMed: | Flavonoids from Picnomon acarna. |
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