hypophyllanthin
naphtho(1,2-d)-1,3-dioxole, 9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-, (7S,8S,9R)-
 
Notes:
None found
  • BOC Sciences
    • BOC Sciences
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      Product(s):
      33676-00-5 HYPOPHYLLANTHIN 95%
       
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CAS Number: 33676-00-5Picture of molecule3D/inchi
FDA UNII: 22ZZ21E33P
Nikkaji Web: J238.475B
MDL: MFCD03424459
XlogP3-AA: 3.60 (est)
Molecular Weight: 430.49750000
Formula: C24 H30 O7
BioActivity Summary: listing
NMR Predictor: Predict (works with chrome or firefox)
Category: information only not used for fragrances or flavors
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar: Search
Google Books: Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents: Search
US Patents: Search
EU Patents: Search
Pubchem Patents: Search
PubMed: Search
NCBI: Search
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Boiling Point: 511.10 °C. @ 760.00 mm Hg (est)
Flash Point: 393.00 °F. TCC ( 200.80 °C. ) (est)
logP (o/w): 3.770 (est)
Soluble in:
 water, 0.5452 mg/L @ 25 °C (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
BOC Sciences
For experimental / research use only.
HYPOPHYLLANTHIN 95%
Carbosynth
For experimental / research use only.
Hypophyllanthin
ExtraSynthese
For experimental / research use only.
Hypophyllanthin (HPLC) ≥90%
Sigma-Aldrich
For experimental / research use only.
Hypophyllanthin analytical standard
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: information only not used for fragrances or flavors
Recommendation for hypophyllanthin usage levels up to:
 not for fragrance use.
 
Recommendation for hypophyllanthin flavor usage levels up to:
 not for flavor use.
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Safety References:
EPI System: View
AIDS Citations: Search
Cancer Citations: Search
Toxicology Citations: Search
EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 182140
National Institute of Allergy and Infectious Diseases: Data
WGK Germany: 3
 (7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole
Chemidplus: 0033676005
RTECS: QL0577000 for cas# 33676-00-5
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References:
 (7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 182140
Pubchem (sid): 135159317
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
CHEMBL: View
HMDB (The Human Metabolome Database): Search
ChemSpider: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 not found in nature
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Synonyms:
(7R,8R,9S)-9-(3,4-dimethoxyphenyl)-4-methoxy-7,8-bis(methoxymethyl)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxole
 hypophyllantin
 naphtho(1,2-d)-1,3-dioxole, 9-(3,4-dimethoxyphenyl)-6,7,8,9-tetrahydro-4-methoxy-7,8-bis(methoxymethyl)-, (7S,8S,9R)-
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Articles:
PubMed: Inhibitory Effects of Standardized Extracts of Phyllanthus amarus and Phyllanthus urinaria and Their Marker Compounds on Phagocytic Activity of Human Neutrophils.
PubMed: Phyllanthin and hypophyllanthin inhibit function of P-gp but not MRP2 in Caco-2 cells.
PubMed: Hepatoprotective activity of Indian Phyllanthus.
PubMed: Enhancing hepatoprotective bioactives of phyllanthus amarus through immobilization by growth promoters and media changes.
PubMed: Clonal propagation of Phyllanthus amarus: A hepatoprotector.
PubMed: Hepatoprotective activity of the Phyllanthus species on tert-butyl hydroperoxide (t-BH)-induced cytotoxicity in HepG2 cells.
PubMed: Endothelium-independent effects of phyllanthin and hypophyllanthin on vascular tension.
PubMed: Recent advances in herbal medicine for treatment of liver diseases.
PubMed: Inhibitory effects of Phyllanthus amarus and its major lignans on human microsomal cytochrome P450 activities: evidence for CYP3A4 mechanism-based inhibition.
PubMed: Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents.
PubMed: Chromium-induced changes in ultramorphology and secondary metabolites of Phyllanthus amarus Schum & Thonn. - an hepatoprotective plant.
PubMed: Separation and quantification of lignans in Phyllanthus species by a simple chiral densitometric method.
PubMed: Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads.
PubMed: Determination of four lignans in Phyllanthus niruri L. by a simple high-performance liquid chromatography method with fluorescence detection.
PubMed: Analysis of lignans from Phyllanthus niruri L. in plasma using a simple HPLC method with fluorescence detection and its application in a pharmacokinetic study.
PubMed: Quantitative determination of phyllanthin and hypophyllanthin in Phyllanthus species by high-performance thin layer chromatography.
PubMed: Antihyperuricemic lignans from the leaves of Phyllanthus niruri.
PubMed: High-performance thin-layer chromatography densitometric method for simultaneous quantitation of phyllanthin, hypophyllanthin, gallic acid, and ellagic acid in Phyllanthus amarus.
PubMed: Comparative pharmacognostic studies of three Phyllanthus species.
PubMed: Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus amarus.
PubMed: Effect of cadmium on growth, ultramorphology of leaf and secondary metabolites of Phyllanthus amarus Schum. and Thonn.
PubMed: 1H- and 13C-nmr assignments of phyllanthin and hypophyllanthin: lignans that enhance cytotoxic responses with cultured multidrug-resistant cells.
PubMed: Antihepatotoxic principles of Phyllanthus niruri herbs.
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