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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| Soluble in: |
| | water, 2285 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for nictoflorin usage levels up to: | | | not for fragrance use.
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| Recommendation for nictoflorin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 5318767 |
| National Institute of Allergy and Infectious Diseases: | Data |
| WGK Germany: | 3 |
| | 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one |
| Chemidplus: | 0017650849 |
References:
| | 5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5318767 |
| Pubchem (sid): | 135231896 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 3-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)- | | 5,7- | dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one | | | kaempferol 3-O-rutinose | | | kaempferol-3-O-beta-rutinoside | | | kaempferol-3-O-rutinoside |
Articles:
| PubMed: | In-time and in-space tandem mass spectrometry to determine the metabolic profiling of flavonoids in a typical sweet cherry (Prunus avium L.) cultivar from Southern Italy. |
| PubMed: | [Study of screening nephroprotective bioactive substances based on triple-color fluorescence probes in Carthami flos]. |
| PubMed: | A systematic study on the influence of the main ingredients of an ivy leaves dry extract on the β2-adrenergic responsiveness of human airway smooth muscle cells. |
| PubMed: | A new acylated flavonoid tetraglycoside with anti-inflammatory activity from Tipuana tipu leaves. |
| PubMed: | Quality evaluation of Carthami Flos by HPLC-UV. |
| PubMed: | Stress-responsive hydroxycinnamate glycosyltransferase modulates phenylpropanoid metabolism in Populus. |
| PubMed: | Chemical composition and bioactivities of flavonoids-rich extract from Davallia cylindrica Ching. |
| PubMed: | Antiangiogenic activity of flavonoids from Melia azedarach. |
| PubMed: | Antinociceptive and anti-inflammatory activities of extract and two isolated flavonoids of Carthamus tinctorius L. |
| PubMed: | Metabolomic analysis of the polyphenols in germinating mung beans (Vigna radiata) seeds and sprouts. |
| PubMed: | Bioactive components from flowers of Sambucus nigra L. increase glucose uptake in primary porcine myotube cultures and reduce fat accumulation in Caenorhabditis elegans. |
| PubMed: | Flavonoids with acetylated branched glycans and bioactivity of Tipuana tipu (Benth.) Kuntze leaf extract. |
| PubMed: | Flavonoids with α-glucosidase inhibitory activities and their contents in the leaves of Morus atropurpurea. |
| PubMed: | Linkage mapping, molecular cloning and functional analysis of soybean gene Fg2 encoding flavonol 3-O-glucoside (1 → 6) rhamnosyltransferase. |
| PubMed: | Two new saponins from tetraploid jiaogulan (Gynostemma pentaphyllum), and their anti-inflammatory and α-glucosidase inhibitory activities. |
| PubMed: | Extraction, gas chromatography-mass spectrometry analysis and screening of fruits of Terminalia chebula Retz. for its antimicrobial potential. |
| PubMed: | Developmental effects on phenolic, flavonol, anthocyanin, and carotenoid metabolites and gene expression in potatoes. |
| PubMed: | Metabolomic profiling and sensorial quality of 'Golden Delicious', 'Liberty', 'Santana', and 'Topaz' apples grown using organic and integrated production systems. |
| PubMed: | Light gazpachos contain higher phytochemical levels than conventional gazpachos. |
| PubMed: | Cytotoxic evaluation of Melia azedarach in comparison with, Azadirachta indica and its phytochemical investigation. |
| PubMed: | Phytochemical composition of Potentilla anserina L. analyzed by an integrative GC-MS and LC-MS metabolomics platform. |
| PubMed: | Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts. |
| PubMed: | A new ent-kaurane diterpenoid glycoside from Isodon japonica var. glaucocalyx. |
| PubMed: | The influence of Bauhinia forficata Link subsp. pruinosa tea on lipid peroxidation and non-protein SH groups in human erythrocytes exposed to high glucose concentrations. |
| PubMed: | Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-κB and STAT3 in transient focal stroke. |
| PubMed: | Yeast α-glucosidase inhibitory phenolic compounds isolated from Gynura medica leaf. |
| PubMed: | Simultaneous quantification and validation of caffeoylquinic acids and flavonoids in Hemistepta lyrata and peroxynitrite-scavenging activity. |
| PubMed: | An optimized method for analysis of phenolic compounds in buds, leaves, and fruits of black currant ( Ribes nigrum L.). |
| PubMed: | On line characterization of 58 phenolic compounds in Citrus fruit juices from Spanish cultivars by high-performance liquid chromatography with photodiode-array detection coupled to electrospray ionization triple quadrupole mass spectrometry. |
| PubMed: | Quality control and analytical test method for Taxus baccata tincture preparation. |
| PubMed: | Nicotiflorin, rutin and chlorogenic acid: phenylpropanoids involved differently in quantitative resistance of potato tubers to biotrophic and necrotrophic pathogens. |
| PubMed: | [Study on flavonoid chemical constituents contained in Memorialis hirta]. |
| PubMed: | Synthesis and antiglycation activity of kaempferol-3-O-rutinoside (nicotiflorin). |
| PubMed: | Antihyperlipidemic components of Cassia auriculata aerial parts: identification through in vitro studies. |
| PubMed: | Gastroprotective effect of Byrsonima sericea DC leaf extract against ethanol-induced gastric injury and its possible mechanisms of action. |
| PubMed: | Characterization of phenolic compounds in flowers of wild medicinal plants from Northeastern Portugal. |
| PubMed: | Stability of the phenolic and carotenoid profile of gazpachos during storage. |
| PubMed: | New acylated anthocyanins and other flavonoids from the red flowers of Clematis cultivars. |
| PubMed: | Potent antiviral flavone glycosides from Ficus benjamina leaves. |
| PubMed: | Phenolic composition and antioxidant activity of aqueous infusions from Capparis spinosa L. and Crithmum maritimum L. before and after submission to a two-step in vitro digestion model. |
| PubMed: | Antioxidant flavonol glycosides from Elaeocarpus serratus and Filicium decipiens. |
| PubMed: | Bioactivities of Chuquiraga straminea sandwith. |
| PubMed: | A new hepatoprotective flavone glycoside from the flowers of Onopordum alexandrinum growing in Egypt. |
| PubMed: | [Study on chemical constituents from leaves of Naudea officinalis]. |
| PubMed: | Isolation and identification of phenolic compounds from Gynura divaricata leaves. |
| PubMed: | [Aromatic constituents of Heteroplexis micocephal and their bioactivities]. |
| PubMed: | A-glucosidase inhibitory activity of kaempferol-3-O-rutinoside. |
| PubMed: | Production of flavonoids in organogenic cultures of Alpinia zerumbet. |
| PubMed: | Sap phytochemical compositions of some bananas in Thailand. |
| PubMed: | Extracts from the Mongolian traditional medicinal plants Dianthus versicolorFisch. and Lilium pumilum Delile stimulate bile flow in an isolated perfused rat liver model. |
| PubMed: | Flavonoids from the stems of Croton caudatus Geisel. var. tomentosus Hook. |
| PubMed: | Identification of bioactive compounds from flowers of black elder (Sambucus nigra L.) that activate the human peroxisome proliferator-activated receptor (PPAR) gamma. |
| PubMed: | Flavonoid glycosides from the leaves of Cissus ibuensis hook (vitaceae). |
| PubMed: | Simultaneous determination of phenolic acids and flavonoids in Lycium barbarum Linnaeus by HPLC-DAD-ESI-MS. |
| PubMed: | [Quality evaluation of Flos Carthami]. |
| PubMed: | Rhusonoside A, a new megastigmane glycoside from Rhus sylvestris, increases the function of osteoblastic MC3T3-E1 cells. |
| PubMed: | Tronchuda cabbage (Brassica oleracea L. var. costata DC): scavenger of reactive nitrogen species. |
| PubMed: | Flavonoids with iNOS inhibitory activity from Pogonatherum crinitum. |
| PubMed: | Quali-quantitative analyses of Flavonoids of Morus nigra L. and Morus alba L. (Moraceae) fruits. |
| PubMed: | [Glycosides from flowers of Jasminum officinale L. var. grandiflorum]. |
| PubMed: | Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotype. |
| PubMed: | Reactive oxygen species scavenging activity of flavone glycosides from Melilotus neapolitana. |
| PubMed: | Phenolic profile of Cydonia oblonga Miller leaves. |
| PubMed: | Chemical constituents from leaves of Celastrus gemmatus Loes. |
| PubMed: | Platelet-activating factor (PAF) receptor binding antagonist activity of the methanol extracts and isolated flavonoids from Chromolaena odorata (L.) King and Robinson. |
| PubMed: | Experimental design for extraction and quantification of phenolic compounds and organic acids in white "Vinho Verde" grapes. |
| PubMed: | In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids from Gingko biloba yellow leaves. |
| PubMed: | Elemanolide sesquiterpenes and eudesmane sesquiterpene glycosides from Centaurea hierapolitana. |
| PubMed: | Antioxidant compounds from Ebenus pinnata. |
| PubMed: | Cytotoxic C-benzylated chalcone and other constituents of Ellipeiopsis cherrevensis. |
| PubMed: | Determination of flavonoids and phenolics and their distribution in almonds. |
| PubMed: | Antioxidant polyphenols in almond and its coproducts. |
| PubMed: | Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1. |
| PubMed: | Topical anti-inflammatory activity of Solenostemma argel leaves. |
| PubMed: | [Applications of two-dimensional liquid chromatography coupled to mass spectrometry for the separation and identification of compounds in ginkgo biloba extracts]. |
| PubMed: | Phenylpropanoids, phenylalanine ammonia lyase and peroxidases in elicitor-challenged cassava (Manihot esculenta) suspension cells and leaves. |
| PubMed: | Bioguided isolation and identification of the nonvolatile antioxidant compounds from fennel (Foeniculum vulgare Mill.) waste. |
| PubMed: | Phytochemical constituents of the aerial parts from Solidago virga-aurea var. gigantea. |
| PubMed: | Phytochemical constituents from Diodia teres. |
| PubMed: | Metabolite profiling of tomato (Lycopersicon esculentum) using 1H NMR spectroscopy as a tool to detect potential unintended effects following a genetic modification. |
| PubMed: | Characterization and content of flavonoid glycosides in genetically modified tomato (Lycopersicon esculentum) fruits. |
| PubMed: | Study of the collision-induced radical cleavage of flavonoid glycosides using negative electrospray ionization tandem quadrupole mass spectrometry. |
| PubMed: | Difference in flavonoid and isoflavone profile between soybean and soy leaf. |
| PubMed: | [Studies on chemical components of Carthamus tinctorius petals]. |
| PubMed: | Inhibition of nitric oxide synthase expression by a methanolic extract of Crescentia alata and its derived flavonols. |
| PubMed: | Flavonoids and phenylpropanoid derivatives from Campanula barbata. |
| PubMed: | New jujubogenin glycosides from Colubrina asiatica. |
| PubMed: | Antimicrobial constituents of the leaves of Acalypha wilkesiana and Aacalypha hispida. |
| PubMed: | Triterpene saponins from Randia formosa. |
| PubMed: | Flavonoids from Goodyera schlechtendaliana. |
| PubMed: | Antimicrobial activity of Mitracarpus scaber extract and isolated constituents. |
| PubMed: | Antioxidant properties of flavonol glycosides from green beans. |
| PubMed: | Flavonol glycosides from cassia hirsuta |
| PubMed: | Antibacterial and chemical evaluation of Chromolaena moritziana. |
| PubMed: | Identification and quantitative analysis of phenolic compounds from the dry extract of Hedera helix. |
| PubMed: | Cyanogenic and non-cyanogenic glycosides from Manihot esculenta. |
| PubMed: | Saponins from leaves of Acanthopanax sieboldianus. |
| PubMed: | Karsoside and scropolioside D, two new iridoid glycosides from Scrophularia ilwensis. |
| PubMed: | [Glycosides of phenolic acid and flavonoids from the leaves of Glycyrrhiza uralensis Ficsh]. |
| PubMed: | [Flavonoids in the flowers of Primula officinalis]. |
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