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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| Soluble in: |
| | water, 505.9 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for eupafolin usage levels up to: | | | not for fragrance use.
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| Recommendation for eupafolin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5317284 |
| Pubchem (sid): | 135053570 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-methoxy- (9CI) | | 2-(3,4- | dihydroxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one | | | flavone, 3',4',5,7-tetrahydroxy-6-methoxy- (8CI) | | 6- | methoxyluteolin | | | nepetin |
Articles:
| PubMed: | HPLC-fingerprints and antioxidant constituents of Phyla nodiflora. |
| PubMed: | Eupafolin inhibits PGE2 production and COX2 expression in LPS-stimulated human dermal fibroblasts by blocking JNK/AP-1 and Nox2/p47(phox) pathway. |
| PubMed: | Separation of nine compounds from Salvia plebeia R.Br. using two-step high-speed counter-current chromatography with different elution modes. |
| PubMed: | Characterisation of polyphenolic compounds in Clerodendrum petasites S. Moore and their potential for topical delivery through the skin. |
| PubMed: | Eupafolin suppresses prostate cancer by targeting phosphatidylinositol 3-kinase-mediated Akt signaling. |
| PubMed: | Further characterization of foliar flavonoids in Crossostephium chinense and their geographic variation. |
| PubMed: | One-Step Separation of Four Flavonoids from Herba Salviae Plbeiae by HSCCC. |
| PubMed: | Phytochemical and antitrypanosomal investigation of the fractions and compounds isolated from Artemisia elegantissima. |
| PubMed: | Eupafolin, a skin whitening flavonoid isolated from Phyla nodiflora, downregulated melanogenesis: Role of MAPK and Akt pathways. |
| PubMed: | Eupafolin and Ethyl Acetate Fraction of Kalanchoe gracilis Stem Extract Show Potent Antiviral Activities against Enterovirus 71 and Coxsackievirus A16. |
| PubMed: | Flavonoids from the Japanese monotypic genus, Nipponanthemum. |
| PubMed: | [Chemical constituents of Eupatorium lindleyanum]. |
| PubMed: | Antiproliferative, antimicrobial and apoptosis inducing effects of compounds isolated from Inula viscosa. |
| PubMed: | Sesquiterpenes and other constituents from Dendranthema zawadskii var. latilobum. |
| PubMed: | Antioxidant, anti-inflammatory and antiproliferative activities of Kalanchoe gracilis (L.) DC stem. |
| PubMed: | Eupatorium perfoliatum L.: phytochemistry, traditional use and current applications. |
| PubMed: | Cytotoxic compounds from the leaves of Gaillardia aristata Pursh. growing in Egypt. |
| PubMed: | Anti-inflammatory activity of Eupatorium perfoliatum L. extracts, eupafolin, and dimeric guaianolide via iNOS inhibitory activity and modulation of inflammation-related cytokines and chemokines. |
| PubMed: | An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatoriumperfoliatum. |
| PubMed: | Eupafolin, a flavonoid isolated from Artemisia princeps, induced apoptosis in human cervical adenocarcinoma HeLa cells. |
| PubMed: | Chemical fingerprint and quantitative analysis of Salvia plebeia R.Br. by high-performance liquid chromatography. |
| PubMed: | Eupafolin: Effect on mitochondrial energetic metabolism. |
| PubMed: | A novel daucosterol derivative and antibacterial activity of compounds from Arctotis arctotoides. |
| PubMed: | Anti-inflammatory activity of flavonoids from Eupatorium arnottianum. |
| PubMed: | Hispidulin: antioxidant properties and effect on mitochondrial energy metabolism. |
| PubMed: | Topical anti-inflammatory activity of flavonoids and a new xanthone from Santolina insularis. |
| PubMed: | [Studies on chemical constituents in bud of Artemisia scoparia (II)]. |
| PubMed: | Cytotoxic activity of nepetin, a flavonoid from Eupatorium ballotaefolium HBK. |
| PubMed: | Iridoids from Globularia dumulosa. |
| PubMed: | Eudesmanolides from Dimerostemma vestitum. |
| PubMed: | Antiproliferative constituents in plants 9. Aerial parts of Lippia dulcis and Lippia canescens. |
| PubMed: | Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship. |
| PubMed: | Flavonoids of Inula britannica protect cultured cortical cells from necrotic cell death induced by glutamate. |
| PubMed: | Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. |
| PubMed: | Anti-phospholipase A2 and anti-inflammatory activity of Santolina chamaecyparissus. |
| PubMed: | Analysis of vervain flavonoids by HPLC/Diode array detector method. Its application to quality control. |
| PubMed: | Mono- and sesquiterpenes and antifungal constituents from Artemisia species. |
| PubMed: | Decreased helenalin-induced cytotoxicity by flavonoids from Arnica as studied in a human lung carcinoma cell line. |
| PubMed: | Influence of a series of natural flavonoids on free radical generating systems and oxidative stress. |
| PubMed: | New Flavonoid Glycosides from Arnicae Flos DAB 91. |
| PubMed: | Flavones and flavonol glycosides from Eupatorium cannabinum L. |
| PubMed: | Screening of the influence of flavonoids on lipoxygenase and cyclooxygenase activity, as well as on nonenzymic lipid oxidation. |
| PubMed: | Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala. |
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