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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 318.70 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 296.00 °F. TCC ( 146.50 °C. ) (est)
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| logP (o/w): | 0.730 (est) |
| Soluble in: |
| | water, 1.003e+005 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-rat LD50 190 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Proceedings of the Society for Experimental Biology and Medicine. Vol. 63, Pg. 423, 1946.
oral-rat LD50 1875 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Proceedings of the Society for Experimental Biology and Medicine. Vol. 63, Pg. 423, 1946.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for myosmine usage levels up to: | | | not for fragrance use.
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| Recommendation for myosmine flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 3-(2,3- | dihydro-1H-pyrrol-5-yl)pyridine | | | pyridine, 3-(1-pyrrolin-2-yl)- | | | pyridine, 3-(3,4-dihydro-2H-pyrrol-5-yl)- (9CI) | | 3-(1- | pyrrolin-2-yl)pyridine |
Articles:
| PubMed: | Simultaneous quantification of tobacco alkaloids and major phase I metabolites by LC-MS/MS in human tissue. |
| PubMed: | Determination of Behaviorally Effective Tobacco Constituent Doses in Rats. |
| PubMed: | Differential effects of non-nicotine tobacco constituent compounds on nicotine self-administration in rats. |
| PubMed: | Determination of caffeine, myosmine, and nicotine in chocolate by headspace solid-phase microextraction coupled with gas chromatography-tandem mass spectrometry. |
| PubMed: | Physiological and biochemical characterization of a novel nicotine-degrading bacterium Pseudomonas geniculata N1. |
| PubMed: | Genetic variation in alkaloid accumulation in leaves of Nicotiana. |
| PubMed: | Analysis of refill liquids for electronic cigarettes. |
| PubMed: | Piperidine, pyridine alkaloid inhibition of fetal movement in a day 40 pregnant goat model. |
| PubMed: | Application of GC-MS/MS for the analysis of tobacco alkaloids in cigarette filler and various tobacco species. |
| PubMed: | Effects of myosmine on antioxidative defence in rat liver. |
| PubMed: | Nicotine, cotinine, and myosmine determination using polymer films of tailor-designed zinc porphyrins as recognition units for piezoelectric microgravimetry chemosensors. |
| PubMed: | Protonating and determining myosmine intactly by association with citrate anion. |
| PubMed: | Biodegradation of nicotine by a novel Strain Shinella sp. HZN1 isolated from activated sludge. |
| PubMed: | A novel pathway for nicotine degradation by Aspergillus oryzae 112822 isolated from tobacco leaves. |
| PubMed: | Inhibition of human aromatase by myosmine. |
| PubMed: | Analysis of myosmine, cotinine and nicotine in human toenail, plasma and saliva. |
| PubMed: | The addition of five minor tobacco alkaloids increases nicotine-induced hyperactivity, sensitization and intravenous self-administration in rats. |
| PubMed: | Validation of a GC-FID method for rapid quantification of nicotine in fermented extracts prepared from Nicotiana tabacum fresh leaves and studies of nicotine metabolites. |
| PubMed: | Evaluation of the mutagenic effects of myosmine in human lymphocytes using the HPRT gene mutation assay. |
| PubMed: | Enhanced radiation damage in irradiated and non-irradiated bystander regions by co-exposure to myosmine. |
| PubMed: | [Rapid determination of alkaloids in tobacco using gas chromatography-mass spectrometry with full scan-selected ion monitoring mode]. |
| PubMed: | Sequential preconcentration by coupling of field amplified sample injection with pseudo isotachophoresis-acid stacking for analysis of alkaloids in capillary electrophoresis. |
| PubMed: | Analyses of tobacco alkaloids by cation-selective exhaustive injection sweeping microemulsion electrokinetic chromatography. |
| PubMed: | Investigation of the reaction of myosmine with sodium nitrite in vitro and in rats. |
| PubMed: | Characterisation of nicotine and related compounds using electrospray ionisation with ion trap mass spectrometry and with quadrupole time-of-flight mass spectrometry and their detection by liquid chromatography/electrospray ionisation mass spectrometry. |
| PubMed: | Tissue distribution and excretion of myosmine after i.v. administration to Long-Evans rats using quantitative whole-body autoradiography. |
| PubMed: | Genotoxic effects of myosmine in a human esophageal adenocarcinoma cell line. |
| PubMed: | Reaction of the tobacco alkaloid myosmine with hydrogen peroxide. |
| PubMed: | Nicotine demethylation in Nicotiana cell suspension cultures: N'-formylnornicotine is not involved. |
| PubMed: | Acute and subacute effects of tobacco alkaloids, tobacco-specific nitrosamines and phenethyl isothiocyanate on N'-nitrosonornicotine metabolism in rats. |
| PubMed: | Metabolism of myosmine in Wistar rats. |
| PubMed: | Unifying mechanism for toxicity and addiction by abused drugs: electron transfer and reactive oxygen species. |
| PubMed: | Iminium metabolite mechanism for nicotine toxicity and addiction: Oxidative stress and electron transfer. |
| PubMed: | Nicotine-related alkaloids and metabolites as inhibitors of human cytochrome P-450 2A6. |
| PubMed: | Fast analysis of nicotine related alkaloids in tobacco and cigarette smoke by megabore capillary gas chromatography. |
| PubMed: | Genotoxic effects of myosmine in human lymphocytes and upper aerodigestive tract epithelial cells. |
| PubMed: | Determination of tobacco alkaloids by gas chromatography with nitrogen-phosphorus detection. |
| PubMed: | New sources of dietary myosmine uptake from cereals, fruits, vegetables, and milk. |
| PubMed: | Nitrosation of dietary myosmine as risk factor of human cancer. |
| PubMed: | Distribution of exposure concentrations and doses for constituents of environmental tobacco smoke. |
| PubMed: | Use of environmental tobacco smoke constituents as markers for exposure. |
| PubMed: | N-Nitrosation of myosmine yields HPB (4-hydroxy-1-(3-pyridyl)-1-butanone) and NNN (N-nitrosonornicotine). |
| PubMed: | Evaluation of micellar electrokinetic capillary chromatography for the analysis of selected tobacco alkaloids. |
| PubMed: | Exposure to environmental tobacco smoke in sixteen cities in the United States as determined by personal breathing zone air sampling. |
| PubMed: | Determination of personal exposure of non-smokers to environmental tobacco smoke in the United States. |
| PubMed: | The effect of varying hormonal and precursor supplementations on levels of nicotine and related alkaloids in cell cultures ofNicotiana tabacum. |
| PubMed: | Microcirculatory effects of nicotine and related alkaloids. |
| PubMed: | Studies on the induction of sister-chromatid exchanges in Chinese hamster ovary cells by various tobacco alkaloids. |
| PubMed: | Comprehensive analysis of urinary metabolites of N'-nitrosonornicotine. |
| PubMed: | Metabolism in the F344 rat of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen. |
| PubMed: | Metabolic beta-hydroxylation and N-oxidation of N'-nitrosonornicotine. |
| PubMed: | A convenient synthesis of myosmine. |
| PubMed: | Determination of myosmine with o-aminobenzaldehyde. |
| PubMed: | Myosmine in cigar tobacco. |
| PubMed: | Some comparative observations on l-nicotine and myosmine. |
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