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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 295.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 627.90 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 462.00 °F. TCC ( 239.00 °C. ) (est)
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| logP (o/w): | 2.580 (est) |
| Soluble in: |
| | water, 678.5 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for rhamnetin usage levels up to: | | | not for fragrance use.
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| Recommendation for rhamnetin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxychromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5281691 |
| Pubchem (sid): | 134970788 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 4H-1- | benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy- (9CI) | | 2-(3,4- | dihydroxyphenyl)-3,5-dihydroxy-7-methoxychromen-4-one | | | flavone, 3,3',4',5-tetrahydroxy-7-methoxy- (8CI) | | | flavone, 7-methoxy-3,3',4',5-tetrahydroxy- | | 7- | methoxyquercetin | | 7- | methylquercetin | | 7-O- | methylquercetin | | | quercetin 7-methyl ether | | beta- | rhamnocitrin | | 3,5,3',4'- | tetrahydroxy-7-methoxyflaone | | 3,3',4',5- | tetrahydroxy-7-methoxyflavone |
Articles:
| PubMed: | Silicon, endophytes and secondary metabolites as grass defenses against mammalian herbivores. |
| PubMed: | Flavonoids enhance melanogenesis in human melanoma cells. |
| PubMed: | A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia. |
| PubMed: | Chemical investigation of the roots of Polygala sibirica L. |
| PubMed: | E-Pharmacophore and Molecular Dynamics Study of Flavonols and Dihydroflavonols as Inhibitors Against DiHydroOrotate DeHydrogenase. |
| PubMed: | Cardioprotective effects of rhamnetin in H9c2 cardiomyoblast cells under H₂O₂-induced apoptosis. |
| PubMed: | Anti-inflammatory activity of rhamnetin and a model of its binding to c-Jun NH2-terminal kinase 1 and p38 MAPK. |
| PubMed: | Characterisation of honeys according to their content of phenolic compounds using high performance liquid chromatography/tandem mass spectrometry. |
| PubMed: | Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines. |
| PubMed: | Rhamnetin attenuates melanogenesis by suppressing oxidative stress and pro-inflammatory mediators. |
| PubMed: | [Chemical constituents from leaves of Nelumbo nucifera]. |
| PubMed: | Anti-inflammatory effect of O-methylated flavonol 2-(3,4-dihydroxy-phenyl)-3,5-dihydroxy-7-methoxy-chromen-4-one obtained from Cassia sophera Linn in rats. |
| PubMed: | [Chemical constituents contained in aerial parts of Emilia sonchifolia]. |
| PubMed: | Differential in vitro and cellular effects of iron chelators for hypoxia inducible factor hydroxylases. |
| PubMed: | Aggregating behavior of phenolic compounds--a source of false bioassay results? |
| PubMed: | Rhamnetin-induced suppression of clonal expansion during early stage of adipogenesis. |
| PubMed: | [Non-alkaloid chemical constituents from Coptis chinensis]. |
| PubMed: | [Preparative isolation and purification of five non-volatile compounds from Fructus caryophylli and Flos caryophylli by high-speed counter-current chromatography]. |
| PubMed: | Tyrosinase inhibitor and radical scavenger fractions and isolated compounds from aerial parts of Peucedanum knappii Bornm. |
| PubMed: | Small molecule inhibitors of the HPV16-E6 interaction with caspase 8. |
| PubMed: | [Simultaneous determination of seven flavonoids in Nervilia fordii with HPLC]. |
| PubMed: | [Studies on the chemical constituents of the herb of Antenoron filiforme]. |
| PubMed: | Effects of coadministration of natural polyphenols with doxycycline or calcium modulators on acute Chlamydia pneumoniae infection in vitro. |
| PubMed: | Optimization of rhamnetin production in Escherichia coli. |
| PubMed: | Phenolic compounds from the aqueous extract of Acacia catechu. |
| PubMed: | Isolation of biologically active constituents from Moringa peregrina (Forssk.) Fiori. (family: Moringaceae) growing in Egypt. |
| PubMed: | Rhamnetin production based on the rational design of the poplar O-methyltransferase enzyme and its biological activities. |
| PubMed: | Simultaneous quantification of eight major constituents in Herba Siegesbeckiae by liquid chromatography coupled with electrospray ionization time-of-flight tandem mass spectrometry. |
| PubMed: | Influence of extraction methods on stability of flavonoids. |
| PubMed: | Ultrasound-assisted extraction of phenolic antioxidants from Acacia confusa flowers and buds. |
| PubMed: | Total extract of Beta vulgaris var. cicla seeds versus its purified phenolic components: antioxidant activities and antiproliferative effects against colon cancer cells. |
| PubMed: | HPLC-DAD-MS analysis of dyes identified in textiles from Mount Athos. |
| PubMed: | 3-Hydroxymethylglutaryl flavonol glycosides from a Mongolian and Tibetan medicine, Oxytropis racemosa. |
| PubMed: | Xanthine oxidase inhibitory activities of extracts and flavonoids of the leaves of Blumea balsamifera. |
| PubMed: | Regioselective O-derivatization of quercetin via ester intermediates. An improved synthesis of rhamnetin and development of a new mitochondriotropic derivative. |
| PubMed: | Flavonoids from the aerial parts of Diplomorpha canescens. |
| PubMed: | Interaction of flavonoids, the naturally occurring antioxidants with different media: a UV-visible spectroscopic study. |
| PubMed: | Screening for fractions of Oxytropis falcata Bunge with antibacterial activity. |
| PubMed: | Polyphenolic profile and bioactivity study of Oenothera speciosa Nutt. aerial parts. |
| PubMed: | Flavonoid-induced morphological modifications of endothelial cells through microtubule stabilization. |
| PubMed: | Cytotoxic constituents of chinese propolis. |
| PubMed: | Flavonoids inhibit the AU-rich element binding of HuC. |
| PubMed: | In vitro anti-influenza viral activities of constituents from Caesalpinia sappan. |
| PubMed: | Antioxidant activities of extracts and flavonoid compounds from Oxytropis falcate Bunge. |
| PubMed: | Determination of rutin and other flavonoids by flow-injection/adsorptive stripping voltammetry using nujol-graphite and diphenylether-graphite paste electrodes. |
| PubMed: | Silicon-mediated accumulation of flavonoid phytoalexins in cucumber. |
| PubMed: | [A new flavonoid from heartwood of Caesalpinia sappan]. |
| PubMed: | Online RP-HPLC-DPPH screening method for detection of radical-scavenging phytochemicals from flowers of Acacia confusa. |
| PubMed: | [Studies on flavonoids of Eupatorium odoratum L]. |
| PubMed: | [Studies on flavonoid constituents from herbs of Artemisia ordosica II]. |
| PubMed: | New flavonol glycosides and new xanthone from Polygala japonica. |
| PubMed: | [Studies on chemical constituents in herb of Myricaria bracteata]. |
| PubMed: | Antioxidant activity of coumarins and flavonols from the resinous exudate of Haplopappus multifolius. |
| PubMed: | Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. |
| PubMed: | Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. |
| PubMed: | [Study on flavonoids from leaf of Ipomoea batatas]. |
| PubMed: | Arbuscular mycorrhizal colonization of tomato by Gigaspora and Glomus species in the presence of root flavonoids. |
| PubMed: | Screening of mango (Mangifera indica L.) cultivars for their contents of flavonol O- and xanthone C-glycosides, anthocyanins, and pectin. |
| PubMed: | On-line characterisation of apple polyphenols by liquid chromatography coupled with mass spectrometry and ultraviolet absorbance detection. |
| PubMed: | Profiling glucosinolates, flavonoids, alkaloids, and other secondary metabolites in tissues of Azima tetracantha L. (Salvadoraceae). |
| PubMed: | Flavonoids from shoots and roots of Trifolium repens (white clover) grown in presence or absence of the arbuscular mycorrhizal fungus Glomus intraradices. |
| PubMed: | Structural requirements of flavonoids for increment of ocular blood flow in the rabbit and retinal function recovery in rat eyes. |
| PubMed: | Allelochemicals of Polygonella myriophylla: chemistry and soil degradation. |
| PubMed: | Isolation of flavonol rhamnosides from Loranthus tanakae and cytotoxic effect of them on human tumor cell lines. |
| PubMed: | Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate. |
| PubMed: | Investigation of natural dyes occurring in historical Coptic textiles by high-performance liquid chromatography with UV-Vis and mass spectrometric detection. |
| PubMed: | Free radical scavenging abilities of flavonoids as mechanism of protection against mutagenicity induced by tert-butyl hydroperoxide or cumene hydroperoxide in Salmonella typhimurium TA102. |
| PubMed: | Identification of flavonol and xanthone glycosides from mango (Mangifera indica L. Cv. "Tommy Atkins") peels by high-performance liquid chromatography-electrospray ionization mass spectrometry. |
| PubMed: | Sesquiterpene lactones from Anthemis altissima and their anti-Helicobacter pylori activity. |
| PubMed: | Comparative study on the free flavonoid aglycones in herbs of different species of Polygonum L. |
| PubMed: | Flavonol glycosides from Cadaba glandulosa. |
| PubMed: | Detection of isorhamnetin glycosides in extracts of apples (Malus domestica cv. "Brettacher") by HPLC-PDA and HPLC-APCI-MS/MS. |
| PubMed: | Four new flavonol glycosides from the leaves of Astragalus caprinus. |
| PubMed: | Characterization of flavonoid--biomembrane interactions. |
| PubMed: | Inhibitory effects of naturally occurring compounds on aflatoxin B(1) biotransformation. |
| PubMed: | Foliar flavonoids of Annonaceae from Brazil: taxonomic significance. |
| PubMed: | Inhibition of beta-carotene-15,15'-dioxygenase activity by dietary flavonoids. |
| PubMed: | Lipid peroxidation inhibitory activity of some constituents isolated from the stem bark of Eucalyptus globulus. |
| PubMed: | Constituents in watercress: inhibitors of histamine release from RBL-2H3 cells induced by antigen stimulation. |
| PubMed: | Inhibitory effect of quercetin metabolites and their related derivatives on copper ion-induced lipid peroxidation in human low-density lipoprotein. |
| PubMed: | Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: implications for the anti-tumor-promoter effect of vegetables. |
| PubMed: | Protective effects of some flavonoids on the renal cellular membrane. |
| PubMed: | 5-Methylflavasperone and rhamnetin from Guiera senegalensis and their antioxidative and 5-lipoxygenase inhibitory activity. |
| PubMed: | Characterization of flavonoids as monofunctional or bifunctional inducers of quinone reductase in murine hepatoma cell lines. |
| PubMed: | Phytochemical and biological study of radal Lomatia hirsuta (Proteaceae). |
| PubMed: | Effects of isorhamnetin, rhamnetin, and quercetin on the concentrations of cholesterol and lipoperoxide in the serum and liver and on the blood and liver antioxidative enzyme activities of rats. |
| PubMed: | Cloning and regulation of flavonol 3-sulfotransferase in cell-suspension cultures of Flaveria bidentis. |
| PubMed: | Rhamnetin 3-p-coumaroylrhamninoside from Rhamnus petiolaris. |
| PubMed: | Inhibition of mitochondrial respiration and cyanide-stimulated generation of reactive oxygen species by selected flavonoids. |
| PubMed: | Studies of the ability of rhamnetin and isorhamnetin to alkylate bacterial DNA. |
| PubMed: | Antiplatelet effects and vasorelaxing action of some constituents of Formosan plants. |
| PubMed: | A study of the genotoxic potential of flavonoids using short-term bacterial assays. |
| PubMed: | The effect of flavonoids on the mutagenic activity of aromatic amines. |
| PubMed: | Flavonoid glycosides from Cassia alata. |
| PubMed: | Three saponins from Oxytropis species. |
| PubMed: | Isolation and studies of the mutagenic activity in the Ames test of flavonoids naturally occurring in medical herbs. |
| PubMed: | Identification of mutagens in Japanese pickles. |
| PubMed: | The effect of some flavonoids on non-enzymatic lipid oxidation and enzymatic oxidation of arachidonic acid. |
| PubMed: | Rhamnetin-3-O-neohesperidoside, a new flavonoid from the leaves of Derris trifoliata. |
| PubMed: | In vivo exposure to plant flavonols. Influence on frequencies of micronuclei in mouse erythrocytes and sister-chromatid exchange in rabbit lymphocytes. |
| PubMed: | Mutagenicity of plant flavonols in the Salmonella/mammalian microsome test: activation of flavonol glycosides by mixed glycosidases from rat cecal bacteria and other sources. |
| PubMed: | Mutagenicity of plant flavonoids: structural requirements for mutagenic activity in Salmonella typhimurium. |
| PubMed: | Products of anaerobic phloroglucinol degradation by Coprococcus sp. Pe15. |
| PubMed: | The partial demethylation of flavones. 3. Preparation of rhamnetin and 7-O-methylmyricetin. |
| PubMed: | The antibacterial effect of the flavonol-dyestuff, rhamnetin. |
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