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7,14-methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))-, sulfate (1:1) (9CI)
Notes:
a quinolizidine alkaloid isolated from several fabaceae including lupinus; spartium; and cytisus. it has been used as an oxytocic and an anti-arrhythmia agent. it has also been of interest as an indicator of cyp2d6 genotype.
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| CAS Number: | 299-39-8 |  3D/inchi
|
| ECHA EINECS - REACH Pre-Reg: | 206-078-4 | |
| FDA UNII: | 3D76XVF9R0 | |
| Molecular Weight: | 332.46396000 | |
| Formula: | C15 H28 N2 O4 S | |
| NMR Predictor: | Predict (works with chrome or firefox) | |
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
| Google Scholar: | Search |
| Google Books: | Search |
| Google Scholar: with word "volatile" | Search |
| Google Scholar: with word "flavor" | Search |
| Google Scholar: with word "odor" | Search |
| Google Patents: | Search |
| US Patents: | Search |
| EU Patents: | Search |
| Pubchem Patents: | Search |
| PubMed: | Search |
| NCBI: | Search |
Physical Properties:
| Assay: | 95.00 to 100.00 % |
| Food Chemicals Codex Listed: | No |
| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est) |
| Soluble in: | |
| water, 6.67E+05mg/L @ 15 °C (exp) | |
| water, 3.801e+005 mg/L @ 25 °C (est) | |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). | |
Cosmetic Information:
| None found |
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Sparteine sulfate >98% |
| ExtraSynthese |
| For experimental / research use only. |
| Sparteine Sulfate Anhydrous |
Safety Information:
| Hazards identification | |
| Classification of the substance or mixture | |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) | |
| None found. | |
| GHS Label elements, including precautionary statements | |
| Pictogram | |
| Hazard statement(s) | |
| None found. | |
| Precautionary statement(s) | |
| None found. | |
| Oral/Parenteral Toxicity: | |
|
parenteral-frog LDLo 375 mg/kg Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 431, 1926. intraperitoneal-guinea pig LDLo 42 mg/kg Journal of Agricultural Research Vol. 32, Pg. 51, 1926. intraperitoneal-mouse LD50 43 mg/kg Journal of Medicinal Chemistry. Vol. 20, Pg. 1668, 1977. intravenous-mouse LD50 15 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: STIFFNESS Japanese Journal of Pharmacology. Vol. 16, Pg. 353, 1966. oral-mouse LD50 350 mg/kg BEHAVIORAL: EXCITEMENT Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 1497, 1980. intravenous-rat LD50 30400 ug/kg BEHAVIORAL: STIFFNESS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Japanese Journal of Pharmacology. Vol. 16, Pg. 353, 1966. | |
| Dermal Toxicity: | |
|
subcutaneous-mouse LD50 117 mg/kg BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: STIFFNESS Japanese Journal of Pharmacology. Vol. 16, Pg. 353, 1966. subcutaneous-rabbit LDLo 80 mg/kg VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION Journal of Pharmacology and Experimental Therapeutics. Vol. 27, Pg. 431, 1926. | |
| Inhalation Toxicity: | |
| Not determined | |
Safety in Use Information:
| Category: | natural substances and extractives | ||
| Recommendation for sparteine sulfate anhydrous usage levels up to: | |||
| not for fragrance use. | |||
| Recommendation for sparteine sulfate anhydrous flavor usage levels up to: | |||
| not for flavor use. | |||
Safety References:
| EPI System: | View |
| AIDS Citations: | Search |
| Cancer Citations: | Search |
| Toxicology Citations: | Search |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 9293 |
| National Institute of Allergy and Infectious Diseases: | Data |
| (1R,2S,9R,10R)-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecane;sulfuric acid | |
| Chemidplus: | 0000299398 |
References:
| (1R,2S,9R,10R)-7,15-diazatetracyclo[7.7.1.02,7.010,15]heptadecane;sulfuric acid | |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 9293 |
| Pubchem (sid): | 134975117 |
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| HMDB (The Human Metabolome Database): | Search |
| VCF-Online: | VCF Volatile Compounds in Food |
| ChemSpider: | View |
Potential Blenders and core components note
| None Found | ||
Potential Uses:
| None Found |
Occurrence (nature, food, other): note
| found in nature |
Synonyms:
| actospar | |
| depasan | |
| (1R,2S,9R,10R)-7,15- | diazatetracyclo[7.7.1.02,7.010,15]heptadecane;sulfuric acid |
| 7,14- | methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))-, sulfate (1:1) (9CI) |
| siarczan sparteiny | |
| spareng | |
| sparteine sulfate | |
| sparteine sulphate anhydrous | |
| sparteine, sulfate (1:1) (8CI) | |
| spartepur | |
| spartin | |
| spartocin | |
| spatym | |
| tocosamine sulfate | |
| tocosimplex |