|
Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | yellow powder (est) |
| Assay: | 95.00 to 100.00 %
|
| Food Chemicals Codex Listed: | No |
| Melting Point: | 303.00 °C. @ 760.00 mm Hg
|
| Boiling Point: | 585.00 °C. @ 760.00 mm Hg (est)
|
| Flash Point: | 444.00 °F. TCC ( 228.80 °C. ) (est)
|
| logP (o/w): | 1.980 (est) |
| Soluble in: |
| | water, 1188 mg/L @ 25 °C (est) |
Organoleptic Properties:
| |
| Odor and/or flavor descriptions from others (if found). |
| |
| |
Cosmetic Information:
Suppliers:
| BOC Sciences |
| For experimental / research use only. |
| Sulfuretin >98%
Odor: characteristic Use: Sulfuretin is a natural flavonoid found in the herbs of Rhus verniciflua. Sulfuretin shows anti-inflammatory activity, which is associated with the suppression of NF-kappaB transcriptional
activity via the inhibitory regulation of IKKbeta phosphorylation
anti-oxidant, anti-inflammatory |
| Carbosynth |
| For experimental / research use only. |
| Sulfuretin
|
| Coompo |
| For experimental / research use only. |
| Sulfuretin from Plants 96%
|
| ExtraSynthese |
| For experimental / research use only. |
| Sulfuretin (HPLC) ≥99%
|
Safety Information:
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
| |
| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
|
Not determined
|
| Dermal Toxicity: |
|
Not determined
|
| Inhalation Toxicity: |
|
Not determined
|
Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for sulfuretin usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for sulfuretin flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
References:
| | (2E)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-1-benzofuran-3-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 5321560 |
| Pubchem (sid): | 135025792 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | aurone, 6,3',4'-trihydroxy- | | (Z)-2-((3,4- | dihydroxyphenyl)methylene)-6-hydroxy-2H-benzofuran-3-one | | (2E)-2-[(3,4- | dihydroxyphenyl)methylidene]-6-hydroxy-1-benzofuran-3-one | | 6,3',4'- | trihydroxyaurone |
Articles:
| PubMed: | Practical, Modular, and General Synthesis of 3-Coumaranones through Gold-Catalyzed Intermolecular Alkyne Oxidation Strategy. |
| PubMed: | The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression. |
| PubMed: | Sulfuretin inhibits 6-hydroxydopamine-induced neuronal cell death via reactive oxygen species-dependent mechanisms in human neuroblastoma SH-SY5Y cells. |
| PubMed: | Simultaneous determination of bioactive phenolic compounds in the stem extract of Rhus verniciflua stokes by high performance liquid chromatography. |
| PubMed: | Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora. |
| PubMed: | Protective effect of detoxified Rhus verniciflua stokes on human keratinocytes and dermal fibroblasts against oxidative stress and identification of the bioactive phenolics. |
| PubMed: | Sulfuretin-induced miR-30C selectively downregulates cyclin D1 and D2 and triggers cell death in human cancer cell lines. |
| PubMed: | Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression. |
| PubMed: | Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses In Vitro. |
| PubMed: | Sulfuretin, a major flavonoid isolated from Rhus verniciflua, ameliorates experimental arthritis in mice. |
| PubMed: | Sulfuretin from heartwood of Rhus verniciflua triggers apoptosis through activation of Fas, Caspase-8, and the mitochondrial death pathway in HL-60 human leukemia cells. |
| PubMed: | Preparative isolation and purification of neuroprotective compounds from Rhus verniciflua by high speed counter-current chromatography. |
| PubMed: | Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines. |
| PubMed: | A scaffold hopping approach to identify novel monoamine oxidase B inhibitors. |
| PubMed: | Antibacterial activity of the flavonoids from Dalbergia odorifera on Ralstonia solanacearum. |
| PubMed: | Synthesis of aurones and their inhibitory effects on nitric oxide and PGE2 productions in LPS-induced RAW 264.7 cells. |
| PubMed: | HPLC-DAD-MS analysis of dyes identified in textiles from Mount Athos. |
| PubMed: | Chemical constituents of the bark of Dipteryx alata vogel, an active species against Bothrops jararacussu venom. |
| PubMed: | Sulfuretin attenuates allergic airway inflammation in mice. |
| PubMed: | Sulfuretin protects against cytokine-induced beta-cell damage and prevents streptozotocin-induced diabetes. |
| PubMed: | Sulfuretin isolated from heartwood of Rhus verniciflua inhibits LPS-induced inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines expression via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells. |
| PubMed: | Anti-inflammatory effects of sulfuretin from Rhus verniciflua Stokes via the induction of heme oxygenase-1 expression in murine macrophages. |
| PubMed: | Cotinus coggygria wood: novel flavanone dimer and development of an HPLC/UV/MS method for the simultaneous determination of fourteen phenolic constituents. |
| PubMed: | Comparison of extraction methods for the analysis of natural dyes in historical textiles by high-performance liquid chromatography. |
| PubMed: | Selective cytotoxic effects on human cancer cell lines of phenolic-rich ethyl-acetate fraction from Rhus verniciflua Stokes. |
| PubMed: | Phytochemical analysis of young fustic (Cotinus coggygria heartwood) and identification of isolated colourants in historical textiles. |
| PubMed: | Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts. |
| PubMed: | Sulfur-substituted naphthalimides as photoactivatable anticancer agents: DNA interaction, fluorescence imaging, and phototoxic effects in cultured tumor cells. |
| PubMed: | Phenolic-rich fraction from Rhus verniciflua Stokes (RVS) suppress inflammatory response via NF-kappaB and JNK pathway in lipopolysaccharide-induced RAW 264.7 macrophages. |
| PubMed: | [Chemical constituents from branch of Broussonetia papyrifera]. |
| PubMed: | Rhus verniciflua stokes extract: radical scavenging activities and protective effects on H2O2-induced cytotoxicity in macrophage RAW 264.7 cell lines. |
| PubMed: | Biocatalytic synthesis of butein and sulfuretin by Aspergillus alliaceus. |
| PubMed: | Anti-platelet effects of bioactive compounds isolated from the bark of Rhus verniciflua Stokes. |
| PubMed: | Flavonoids purified from Rhus verniciflua Stokes actively inhibit cell growth and induce apoptosis in human osteosarcoma cells. |
| PubMed: | Extract from Rhus verniciflua Stokes is capable of inhibiting the growth of human lymphoma cells. |
| PubMed: | Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua. |
| PubMed: | Antirheumatoid arthritis effect of Rhus verniciflua and of the active component, sulfuretin. |
| PubMed: | Antioxidant activity from the stem bark of Albizzia julibrissin. |
| PubMed: | Potential cancer chemopreventive constituents of the seeds of Dipteryx odorata (tonka bean). |
| PubMed: | Identification of Rhus verniciflua Stokes compounds that exhibit free radical scavenging and anti-apoptotic properties. |
| PubMed: | Activity-guided isolation of antioxidative constituents of Cotinus coggygria. |
| PubMed: | Three new flavonoids and antiallergic, anti-inflammatory constituents from the heartwood of Dalbergia odorifera. |
| PubMed: | Natural polyhydroxylated compounds as inhibitors of xanthine oxidase. |
| PubMed: | The sensitizing capacity of sulfuretin. |
| PubMed: | Contact dermatitis to sesquiterpene lactones in Inula viscosa Aiton. |
|