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Category: natural substances and extractives
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00 %
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 554.40 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 470.00 °F. TCC ( 243.50 °C. ) (est)
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| logP (o/w): | 3.060 (est) |
| Soluble in: |
| | water, 8.701 mg/L @ 25 °C (est) |
Organoleptic Properties:
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| Odor and/or flavor descriptions from others (if found). |
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Cosmetic Information:
Suppliers:
| Alfa Biotechnology |
| For experimental / research use only. |
| 5,7,3',4',5'-Pentamethoxyflavone 98%
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| BOC Sciences |
| For experimental / research use only. |
| 5,7,3',4',5'-Pentamethoxyflavone 98%
Odor: characteristic Use: 5,7,3',4',5'-Pentamethoxyflavone is a flavonoid showing anti-inflammatory and cancer chemopreventive activities.
Inhibits ATPase activity and has chemisensitizing effects |
| Carbosynth |
| For experimental / research use only. |
| 3',4',5',5,7-Pentamethoxyflavone
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| ExtraSynthese |
| For experimental / research use only. |
| Tricetin-3',4',5',5,7-pentamethylether (HPLC) ≥95%
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| Santa Cruz Biotechnology |
| For experimental / research use only. |
| 3',4',5',5,7-Pentamethoxyflavone
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Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
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Not determined
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | natural substances and extractives |
| Recommendation for tricetin-3',4',5',5,7-pentamethyl ether usage levels up to: | | | not for fragrance use.
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| Recommendation for tricetin-3',4',5',5,7-pentamethyl ether flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| EPI System: | View |
| EPA ACToR: | Toxicology Data |
| EPA Substance Registry Services (SRS): | Registry |
| Laboratory Chemical Safety Summary : | 493376 |
| National Institute of Allergy and Infectious Diseases: | Data |
| | 5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one |
References:
| | 5,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 493376 |
| Pubchem (sid): | 202824455 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 5,7- | dimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one | | 3',4',5,5',7- | pentamethoxyflavone | | | tricetin-3',4',5',5,7-pentamethylether |
Articles:
| PubMed: | Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone). |
| PubMed: | APC10.1 cells as a model for assessing the efficacy of potential chemopreventive agents in the Apc(Min) mouse model in vivo. |
| PubMed: | Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy. |
| PubMed: | Determination of 3',4',5',5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection. |
| PubMed: | Pyrano chalcones and a flavone from Neoraputia magnifica and their Trypanosoma cruzi glycosomal glyceraldehyde-3-phosphate dehydrogenase-inhibitory activities. |
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