endo-1,4-beta-xylanase II
 
Notes:
enzymes which catalyze the endohydrolysis of 1,4-beta-d-xylosidic linkages in xylans.
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CAS Number: 140222-29-3Picture of molecule3D/inchi
Molecular Weight: 1423.64492000
Formula: C81 H86 O21 Si
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Category: natural substances and extractives
 
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 FDA/DG SANTE Petitions, Reviews, Notices:
GRN 628 endo-1,4-beta-xylanase from Trichoderma reesei View - notice PDF
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Physical Properties:
Assay: 95.00 to 100.00 % 
Food Chemicals Codex Listed: No
Flash Point: 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w): 20.277 (est)
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Organoleptic Properties:
 
Odor and/or flavor descriptions from others (if found).
 
 
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Cosmetic Information:
None found
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Suppliers:
 None found
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Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
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Safety in Use Information:
Category: natural substances and extractives
Recommendation for endo-1,4-beta-xylanase II usage levels up to:
 not for fragrance use.
 
Recommendation for endo-1,4-beta-xylanase II flavor usage levels up to:
 not for flavor use.
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Safety References:
European Food Safety Authority (EFSA) reference(s):
Scientific Opinion on the safety and efficacy of Safizym® X (endo-1,4-beta-xylanase) as a feed additive for chickens and turkeys for fattening and laying hens
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Scientific Opinion on the safety and efficacy of Rovabio® Excel (endo-1,3(4)-beta-glucanase and endo-1,4-beta-xylanase) as a feed additive for lactating sows
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Scientific Opinion on the efficacy of Natugrain® TS/TS L (endo-1,4-beta-xylanase and endo-1,4-beta-glucanase) as a feed additive for laying hens
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Scientific Opinion on the safety of Hostazym X as a feed additive for poultry and pigs
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Annual report on the preparatory work for the evaluation of food enzymes – Toxicological part
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Safety and efficacy of HOSTAZYM® X (endo-1,4-ß-xylanase) as a feed additive for chickens reared for laying and minor poultry species reared for laying
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Safety and efficacy of Bergazym® P100 (endo-1,4-ß-xylanase) as a feed additive for chickens for fattening, weaned piglets and pigs for fattening
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Safety evaluation of the food enzyme endo-1,4-ß-xylanase from genetically modified Aspergillus niger strain XYL
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Safety and efficacy of Beltherm MP/ML (endo-1,4-beta-xylanase) as a feed additive for chickens for fattening, chickens reared for laying, turkeys for fattening, turkeys reared for breeding, turkeys for breeding purposes and minor poultry species
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Safety and efficacy of RONOZYME® WX (endo-1,4-ß-xylanase) as a feed additive for laying hens
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Safety and efficacy of ENZY CARBOPLUS® (endo-1,4-beta-xylanase and endo-1,3(4)-beta-glucanase) as a feed additive for avian species, weaned piglets and minor weaned porcine species
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Safety and efficacy of ECONASE® XT (endo-1,4-ß-xylanase) as a feed additive for pigs for fattening
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Safety and efficacy of ECONASE® XT (endo-1,4-ß-xylanase) as a feed additive for laying hens
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Safety evaluation of the food enzyme endo-1,4-ß-xylanase from a genetically modified Aspergillus niger (strain XEA)
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Safety and efficacy of Amylofeed® (endo-1,3(4)-ß-glucanase and endo-1,4-ß-xylanase and a-amylase) as a feed additive for piglets and minor growing porcine species
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Safety evaluation of the food enzyme endo-1,4-ß-xylanase from a genetically modified Trichoderma reesei (strain DP-Nzd22)
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Safety and efficacy of Beltherm MP/ML (endo-1,4-beta-xylanase) as a feed additive for chickens for fattening, chickens reared for laying, turkeys for fattening, turkeys reared for breeding, turkeys for breeding purposes and minor poultry species
View page or View pdf
Safety and efficacy of Beltherm MP/ML (endo-1,4-beta-xylanase) as a feed additive for piglets, pigs for fattening and other porcine species
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Safety and efficacy of FRA® Octazyme C Dry(endo-1,4-ß-xylanase, mannan-endo-1,4-ß-mannosidase, a-amylase, endo-1,3(4)-ß-glucanase, pectinase, endo-1,4-ß-glucanase, protease, a-galactosidase) as a feed additive for weaned piglets and chickens for fattening
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Safety evaluation of the food enzyme endo-1,4-ß-xylanase and ß-glucanase from Disporotrichum dimorphosporum strain DXL
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EPA ACToR: Toxicology Data
EPA Substance Registry Services (SRS): Registry
Laboratory Chemical Safety Summary : 16132247
National Institute of Allergy and Infectious Diseases: Data
Chemidplus: 0140222293
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References:
NIST Chemistry WebBook: Search Inchi
Pubchem (cid): 16132247
Pubchem (sid): 135230349
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Other Information:
(IUPAC): Atomic Weights of the Elements 2011 (pdf)
Videos: The Periodic Table of Videos
tgsc: Atomic Weights use for this web site
(IUPAC): Periodic Table of the Elements
HMDB (The Human Metabolome Database): Search
VCF-Online: VCF Volatile Compounds in Food
ChemSpider: View
Wikipedia: View
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Potential Blenders and core components note
 
None Found
 
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Potential Uses:
None Found
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Occurrence (nature, food, other): note
 endo-1,4-beta-xylanase II
Search  PMC Picture
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Synonyms:
endo-1,4-beta-xylanase from trichoderma reesei
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Articles:
PubMed: [Enhancing stability of Trichoderma reesei xylanase (XYN II) by site-directed mutagenesis].
PubMed: Irreversible thermal denaturation of Trichoderma reesei endo-1,4-beta-xylanase II and its three disulfide mutants characterized by differential scanning calorimetry.
PubMed: Determination of steady-state kinetic parameters for a xylanase-catalyzed hydrolysis of neutral underivatized xylooligosaccharides by mass spectrometry.
PubMed: Increased alkali stability in Trichoderma reesei endo-1, 4-beta-xylanase II by site directed mutagenesis.
PubMed: Engineering the thermostability of Trichoderma reesei endo-1,4-beta-xylanase II by combination of disulphide bridges.
PubMed: Characterization of mutant xylanases using fourier transform ion cyclotron resonance mass spectrometry: stabilizing contributions of disulfide bridges and N-terminal extensions.
PubMed: A de novo designed N-terminal disulphide bridge stabilizes the Trichoderma reesei endo-1,4-beta-xylanase II.
PubMed: MM-PBSA free energy analysis of endo-1,4-xylanase II (XynII)-substrate complexes: binding of the reactive sugar in a skew boat and chair conformation.
PubMed: Engineering of multiple arginines into the Ser/Thr surface of Trichoderma reesei endo-1,4-beta-xylanase II increases the thermotolerance and shifts the pH optimum towards alkaline pH.
PubMed: A combination of weakly stabilizing mutations with a disulfide bridge in the alpha-helix region of Trichoderma reesei endo-1,4-beta-xylanase II increases the thermal stability through synergism.
PubMed: Thermostability of endo-1,4-beta-xylanase II from Trichoderma reesei studied by electrospray ionization Fourier-transform ion cyclotron resonance MS, hydrogen/deuterium-exchange reactions and dynamic light scattering.
PubMed: Three-dimensional structure of endo-1,4-beta-xylanase II from Trichoderma reesei: two conformational states in the active site.
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